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Cytochrome c, somatic

Cytochrome c
This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PrP, caspase-3, bcl-2, Bax, V1a
Papers using Cytochrome c antibodies
HDAC6 inhibition enhances 17-AAG–mediated abrogation of Hsp90 chaperone function in human leukemia cells.
Rishi Arun, In PLoS ONE, 2007
... ) (Cell Signalling Technology, Beverly, MA); PARP-1 (Oncogene Science, Uniondale, NY); cytochrome C (BD Pharmingen, Becton Dickinson, Franklin Lakes, NJ); actin, ...
Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease
Kanthasamy Arthi et al., In Molecular Brain, 2006
... Cytochrome c ELISA kit was obtained from MBL International Corp ...
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins 1.
Linden Rafael, In PLoS ONE, 2003
... p38, Caveolin-1, caspase-3, cytochrome C antibody and all the corresponding HRP conjugated secondary antibodies were bought from Cell Signaling Technologies ...
Mitochondrial control of cell death.
Gartel Andrei L., In PLoS ONE, 1999
... Smac/DIABLO and Cytochrome c antibodies were purchased from BD biosciences (Oxford, UK) ...
Involvement of Avidity for Major Histocompatibility Complex in Homeostasis of Naive and Memory T Cells
Stockinger Brigitta et al., In The Journal of Experimental Medicine, 1999
... ), and pigeon cytochrome C (PCC)-specific AND (32) TCR-transgenic mice were kept on ...
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Papers on Cytochrome c
The cytoprotective effects of oleanolic acid in human umbilical vascular endothelial cells is mediated via UCP2/ROS/ cytochrome C/AIF pathway.
Han et al., Qingdao, China. In J Cardiovasc Pharmacol, Feb 2016
The protein expression levels of uncoupling protein 2 (UCP2), cytochrome C and apoptosis induction factors (AIF) were measured by western blotting.
4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells.
Fu et al., Linyi, China. In Biochem Biophys Res Commun, Feb 2016
Further, adding 4SC-202 in HCC cells activated mitochondrial apoptosis pathway, which was evidenced by mitochondrial permeability transition pore (mPTP) opening, cytochrome C cytosol release and caspase-3/-9 activation.
Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells.
Ghassempour et al., Tehrān, Iran. In Fitoterapia, Feb 2016
The mitochondrial pathway of apoptosis revealed that cytochrome C is released from mitochondria to cytosol, associated with the activation of caspase-9 and -3, and the cleavage of poly (ADP-ribose) polymerase (PARP).
Combining size-exclusion chromatography with differential hydrogen-deuterium exchange to study protein conformational changes.
Helmy et al., Rahway, United States. In J Chromatogr A, Jan 2016
Temperature and pressure were independently studied with regards to their effect on the proteins' (insulin, cytochrome C, ubiquitin, and myoglobin) conformational changes in the solution.
Extracellular electron transfer from cathode to microbes: application for biofuel production.
Sang et al., Seoul, South Korea. In Biotechnol Biofuels, Dec 2015
It was proposed that gram-positive bacteria, in the absence of cytochrome C, would accept electrons using a cascade of membrane-bound complexes such as membrane-bound Fe-S proteins, oxidoreductase, and periplasmic enzymes.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Shi et al., Nanning, China. In Theriogenology, Dec 2015
Adding BMP1 recombinant protein to the culture medium of the GCs increased the expression of the key cell cycle regulators such as cyclin D1 and cyclin D2 and downregulated the expression of cell apoptosis pathway genes such as Cytochrome C, Fas, FasL, and Chop, both at the mRNA and at the protein levels.
Macrocyclic metal complexes for metalloenzyme mimicry and sensor development.
Spiccia et al., Australia. In Acc Chem Res, Sep 2015
The metal coordination environment therein is often generated from residues inherent to the protein, small exogenous molecules (e.g., aqua ligands) and/or macrocyclic porphyrin units found, for example, in hemoglobin, myoglobin, cytochrome C, cytochrome C oxidase, and vitamin B12.
Conti et al., Cagliari, Italy. In J Biol Regul Homeost Agents, Apr 2015
Vitamin B1 influences pro-apoptotic proteins, mitochondrial membrane potential, cytochrome C release, protein kinases, p38-MAPK, suppresses oxidative stress-induced NF-kappaB and has anti-inflammatory properties.
Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease.
Tipoe et al., Hong Kong, Hong Kong. In Hepatobiliary Pancreat Dis Int, Apr 2015
RESULTS: The mechanisms of chronic aerobic exercise in regulating the outcome of NAFLD include: (i) reducing intrahepatic fat content by down-regulating sterol regulatory element-binding protein-1c and up-regulating peroxisome proliferator-activated receptor gamma expression levels; (ii) decreasing hepatic oxidative stress through modulating the reactive oxygen species, and enhancing antioxidant enzymes such as catalase and glutathione peroxidase; (iii) ameliorating hepatic inflammation via the inhibition of pro-inflammatory mediators such as tumor necrosis factor-alpha and interleukin-1 beta; (iv) attenuating mitochondrial dependent apoptosis by reducing cytochrome C released from the mitochondria to the cytosol; and (v) inducing hepato-protective autophagy.
Electronic connection between the quinone and cytochrome C redox pools and its role in regulation of mitochondrial electron transport and redox signaling.
Osyczka et al., Kraków, Poland. In Physiol Rev, 2015
One of the mitochondrial complexes, complex III (cytochrome bc1 or ubiquinol:cytochrome c oxidoreductase), provides an electronic connection between these two diffusible redox pools linking in a fully reversible manner two-electron quinone oxidation/reduction with one-electron cytochrome c reduction/oxidation. Several features of this homodimeric enzyme implicate that in addition to its well-defined function of contributing to generation of proton-motive force, cytochrome bc1 may be a physiologically important point of regulation of electron flow acting as a sensor of the redox state of mitochondria that actively responds to changes in bioenergetic conditions.
Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism.
Reiter et al., San Antonio, United States. In Molecules, 2014
Melatonin metabolism is highly complex with these enzymatic processes having evolved from cytochrome C. In addition to its enzymatic degradation, melatonin is metabolized via pseudoenzymatic and free radical interactive processes.
Three toxic gases meet in the mitochondria.
Collman et al., Dijon, France. In Front Physiol, 2014
The rationale of the study was two-fold: (i) develop a functional synthetic model of the Cytochrome c oxidase (CcO) active site, (ii) use it as a convenient tool to understand or predict the outcome of the reaction of CcO with ligands (physiologically relevant gases and other ligands).
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.
Carter et al., Iowa City, United States. In J Biol Chem, 2012
mitochondrial import and direct electron transfer from cytochrome c to Rac1 modulates mitochondrial H(2)O(2) production in alveolar macrophages pulmonary fibrosis.
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome.
De la Rosa et al., Sevilla, Spain. In Febs Lett, 2012
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome.
Label-free Raman observation of cytochrome c dynamics during apoptosis.
Fujita et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2012
Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells.
TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release.
Lau et al., Chicago, United States. In Plos One, 2011
CCN1 promotes the activation of p53 and p38 MAPK, which mediate enhanced cytochrome c release to amplify the cytotoxicity of TNFalpha.
Mechanisms of TRAIL and gemcitabine induction of pancreatic cancer cell apoptosis.
Li et al., Jinan, China. In Asian Pac J Cancer Prev, 2010
The levels of cellular apoptosis-associated proteins such as Smac/DIABLO, Cyto C, and the activated fragment of caspase-3 increased in pancreatic cancer cells, but the expression of XIAP was significantly decreased after 24 h treatment with the combination of TRAIL and gemcitabine.
A cytochrome C oxidase model catalyzes oxygen to water reduction under rate-limiting electron flux.
Chidsey et al., Stanford, United States. In Science, 2007
We studied the selectivity of a functional model of cytochrome c oxidase's active site that mimics the coordination environment and relative locations of Fe(a3), Cu(B), and Tyr(244).
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome.
Tang et al., United States. In Cell, 2006
Cytochrome c (CC)-initiated Apaf-1 apoptosome formation represents a key initiating event in apoptosis.
Electron-tunneling pathways in cytochrome C.
Gray et al., In Science, 1992
Distant Fe(2+)-Ru(3+) electronic couplings have been extracted from intramolecular electrontransfer rates in Ru(histidine(x)) (where X = 33, 39, 62, and 72) derivatives of cytochrome c.
More papers using Cytochrome c antibodies
Modulation of DNA polymerases alpha, delta and epsilon by lactate dehydrogenase and 3-phosphoglycerate kinase.
Brooks George, In PLoS ONE, 1997
... The homogeneity of the sub-fractions of the mitochondria were confirmed utilizing cytochrome C antibodies (Abcam) for the outermembrane/inner membrane ...
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