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Cystathionine gamma-Lyase, cystathionase, CTH, gamma-cystathionase, Cys3
putative cystathionine gamma-lyase enzyme [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, AGE
Papers on Cystathionine gamma-Lyase
The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix.
Dietrich et al., Erlangen, Germany. In Cell Mol Life Sci, Feb 2016
Here, we discovered that the dimerization of a predicted helix within the carboxyl-terminus (CTH) is essential for the activity of TPC1.
Biosynthesis and Reactivity of Cysteine Persulfides in Signaling.
Banerjee et al., Ann Arbor, United States. In J Am Chem Soc, Feb 2016
Our detailed kinetic analyses demonstrate a robust capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-synthase and γ-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CSE only.
A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis.
Hartung et al., Baltimore, United States. In Arch Toxicol, Jan 2016
The mitochondrial toxicants and established experimental PD agents, rotenone and MPP(+), perturbed genes involved in one-carbon metabolism and transsulfuration pathways (ASS1, CTH, and SHTM2) as in 2D cultures.
Resveratrol Stimulates Hydrogen Sulfide (H2 S) Formation to Relax Murine Corpus Cavernosum.
Ahmed et al., İzmir, Turkey. In J Sex Med, Oct 2015
MAIN OUTCOME MEASURES: Endothelial NO synthase (eNOS) inhibitor Nω-Nitro-L-arginine (L-NNA, 0.1 mM) or H2 S inhibitor aminooxyacetic acid (AOAA, 2 mM) which inhibits both cystathionine-β-synthase (CBS) and cystathionine-gamma-lyase (CSE) enzyme or combination of AOAA with PAG (CSE inhibitor) has been used in the presence/absence of RVT (0.1 mM, 30 min) to elucidate the role of NO or H2 S pathways on the effects of RVT in MCC.
Protective effects of hydrogen sulfide anions against acetaminophen-induced hepatotoxicity in mice.
Kumagai et al., In J Toxicol Sci, 2014
We utilized cystathionine γ-lyase-deficient (Cth(-/-)) mice that are highly sensitive to acetaminophen toxicity.
[Cystathionine γ-lyase].
Wróbel et al., Kraków, Poland. In Postepy Hig Med Dosw (online), 2013
γ-Cystathionase (CTH, EC:,
Regulation of cystathionine gamma-lyase/H₂S system and its pathological implication.
Yang et al., Thunder Bay, Canada. In Front Biosci, 2013
Cystathionine gamma-lyase (CSE) is one major H2S-producing enzyme with L-cysteine as the main substrate in mammalian cells.
[Hydrogen sulfide and its effect on pancreatic beta-cells].
Kimura et al., Ōita, Japan. In Nihon Rinsho, 2013
In pancreatic beta-cells, H2S can be produced by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE).
[Hydrogen sulfide and penile erection].
Jiang et al., China. In Zhonghua Nan Ke Xue, 2012
In mammalians, H2S is mainly synthesized by two proteases, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).
Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines.
Zha et al., Shanghai, China. In Cell Signal, 2012
PI3K/AKT pathway increased the activity of cystathionine gamma-lyase gene promoter via Sp1.
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Ishii et al., Tokyo, Japan. In Free Radic Biol Med, 2012
The 6 x Met-fed Cth(-/-) (not 1 x Met-fed Cth(-/-) or 6 x Met-fed wild type) mice displayed acute hepatitis, which was characterized by markedly elevated levels of serum alanine/aspartate aminotransferases and serum/hepatic lipid peroxidation
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.
Austin et al., Hamilton, Canada. In J Biol Chem, 2012
CSE is a critical factor in GSH synthesis and may act to protect the liver and kidney from a variety of conditions that cause ER stress.
Characterization of hydrogen sulfide and its synthases, cystathionine β-synthase and cystathionine γ-lyase, in human prostatic tissue and cells.
Jin et al., Beijing, China. In Urology, 2012
CTH is present in prostatic tissues and both normal and malignant prostate cell lines, including stromal compartments and the stromal cell line WPMY-1. It is downregulated by dihydrotestosterone.
Vitamin B6 deficiency, genome instability and cancer.
Lu et al., Kunming, China. In Asian Pac J Cancer Prev, 2011
It comprises a group of three related 3-hydroxy-2-methyl-pyrimidine derivatives: pyridoxine (PN), pyridoxal (PL), pyridoxamine (PM) and their phosphorylated derivatives [pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP)], In the folate metabolism pathway, PLP is a cofactor for the mitochondrial and cytoplasmic isozymes of serine hydroxymethyltransferase (SHMT2 and SHMT1), the P-protein of the glycine cleavage system, cystathionine β-synthase (CBS) and γ-cystathionase, and betaine hydroxymethyltransferase (BHMT), all of which contribute to homocysteine metabolism either through folate- mediated one-carbon metabolism or the transsulfuration pathway.
Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice.
Wu et al., Saskatoon, Canada. In Plos One, 2010
overproduction of MG in CSE(-/-) mice is due to a H(2)S-mediated down-regulation of the PGC-1alpha-FBPase pathway, further suggesting the important role of H(2)S in the regulation of glucose metabolism and MG generation.
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.
Wang et al., Saskatoon, Canada. In Science, 2008
study shows H2S is physiologically generated by cystathionine gamma-lyase (CSE) & genetic deletion CSE markedly reduces H2S levels in serum & tissue; mice lacking CSE display pronounced hypertension & diminished endothelium-dependent vasorelaxation
Hydrogen sulphide and its therapeutic potential.
Szabó, Seattle, United States. In Nat Rev Drug Discov, 2007
The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase.
Accumulation of cystine auxotrophic thymocytes accompanying type C viral leukemogenesis in the mouse.
Lazarus et al., In Cell, 1976
Compared to CYS+ cells, the CYS- lines appear to be relatively deficient in the enzyme cystathionase, which catalyzes the cleavage of CSN to CYS and alpha-ketobutyrate.
Vitamin B6-responsive and -unresponsive cystathioninuria: two variant molecular forms.
Hirschhorn et al., In Science, 1976
Cystathionase activity in a lymphoid cell line extracts from a vitamin B6-responsive patient with cystathioninuria was increased strikingly by pyridoxal phosphate.
Absence of cystathionase in human fetal liver: is cystine essential?
Raiha et al., In Science, 1970
Cystathionase activity is not measurable in the livers of 24 human fetuses and 3 premature infants, and the concentration of cystathionine in the liver is higher than that of the brain.
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