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Cysteine-rich, angiogenic inducer, 61

Cyr61, CCN1
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: connective tissue growth factor, NOV, CAN, V1a, WISP-1
Papers using Cyr61 antibodies
Epidermal Growth Factor Induces WISP-2/CCN5 Expression in Estrogen Receptor-{alpha}-Positive Breast Tumor Cells through Multiple Molecular Cross-talks
Banerjee Snigdha et al., In Molecular Cancer, 2004
... Human polyclonal anti-rabbit Cyr61 antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Nuclear accumulation of beta-catenin is a common and early event during neoplastic progression of barrett esophagus
Jamal M. Mazen et al., In ISRN Gastroenterology, 1999
... To knock down CCN1, cells were transfected with shRNA against CCN1 in pRFP-C-RS vector (Origene, Rockville, MD), which constitutively ...
Papers on Cyr61
CCN1 (CYR61) and CCN3 (NOV) signaling drives human trophoblast cells into senescence and stimulates migration properties.
Gellhaus et al., Essen, Germany. In Cell Adh Migr, Feb 2016
This study focused on the regulation properties of glycosylated and non-glycosylated matricellular CCN1 and CCN3, primarily for proliferation control in the benign SGHPL-5 trophoblast cell line, which originates from the first-trimester placenta.
Dexamethasone Inhibits TGF-β1-induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61.
Shin et al., Cheju, South Korea. In Cancer Res Treat, Jan 2016
CYR61 protein promotes migration and the epithelial-mesenchymal transition in several cancer cell types.
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
Jiang et al., Beijing, China. In Int J Mol Med, Dec 2015
The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6.
CCN1 suppresses pulmonary vascular smooth muscle contraction in response to hypoxia.
Jin et al., Boston, United States. In Pulm Circ, Dec 2015
CCN1 (Cyr61), discovered in past decade, belongs to the Cyr61-CTGF-Nov (CCN) family.
G Protein-Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation.
Brown et al., San Diego, United States. In Mol Pharmacol, Jul 2015
We also focus on the importance of two prominent downstream transcriptional gene targets, the inflammatory mediator cyclooxygenase 2, and the matricellular protein cysteine-rich angiogenic inducer 61 (CCN1).
Akbu-LAAO exhibits potent anti-tumor activity to HepG2 cells partially through produced H2O2 via TGF-β signal pathway.
Sun et al., Dalian, China. In Sci Rep, 2014
TGF-β pathway related molecules CYR61, p53, GDF15, TOB1, BTG2, BMP2, BMP6, SMAD9, JUN, JUNB, LOX, CCND1, CDK6, GADD45A, CDKN1A were deregulated in HepG2 following Akbu-LAAO stimulation.
Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities.
Chaqour et al., United States. In Hum Genomics, 2014
"CCN" is an acronym referring to the first letter of each of the first three members of this original group of mammalian functionally and phylogenetically distinct extracellular matrix (ECM) proteins [i.e., cysteine-rich 61 (CYR61), connective tissue growth factor (CTGF), and nephroblastoma-overexpressed (NOV)].
Study of Cysteine-Rich Protein 61 Genetic Polymorphism in Predisposition to Fracture Nonunion: A Case Control.
Mahdi et al., Lucknow, India. In Genet Res Int, 2014
In the present study, we aim to examine the CYR61 gene polymorphism in fracture nonunion patients and the correlation with clinical findings.
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
Lamb et al., Houston, United States. In Nat Med, 2014
Elevated levels of VAMP7 markedly intensified ESR1-potentiated transcriptional activity by increasing ESR1 protein cellular content upon ligand stimulation and upregulated the expression of estrogen-responsive genes including ATF3, CYR61 and CTGF, all of which have been implicated in human hypospadias.
Input of microenvironmental regulation on colorectal cancer: role of the CCN family.
Kuo et al., Taipei, Taiwan. In World J Gastroenterol, 2014
Many studies have shown that CCN members, such as CCN1, CCN2, CCN3, Wnt-induced secreted protein (WISP)-1, WISP-2, and WISP-3, are dysregulated in CRC, which implies potential diagnostic markers or therapeutic targets clinically.
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking.
Imhof et al., Genève, Switzerland. In Semin Immunopathol, 2014
Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells.
Cysteine-rich protein 61 (CCN1) mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts.
Fisher et al., Ann Arbor, United States. In J Cell Biochem, 2012
Given the ability of CCN1 to regulate both production and degradation of type I collagen, it is likely that elevated-CCN1 functions as an important mediator of collagen loss, which is observed in aged human skin.
NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8/SVneo cells induced by CYR61.
Hu et al., Nanjing, China. In Placenta, 2012
cysteine-rich angiogenic inducer 61 may promote trophoblast cell migration and invasion through upregulation of NUR77 protein leading to the increase of matrix metalloproteinase 2(MMP2) release and the downregulation of tissue inhibitor of MMP2 expression
Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid arthritis.
Li et al., Shanghai, China. In J Immunol, 2012
Cyr61 stimulates interleukin (IL)-6 production by fibroblast-like synoviocytes via the integrin avbeta5/Akt/NF-kappaB signaling pathway in rheumatoid arthritis, while the increased IL-6 in turn promotes T helper (Th)17 cell differentiation.
Matricellular proteins in cardiac adaptation and disease.
Frangogiannis, United States. In Physiol Rev, 2012
Thrombospondin (TSP)-1, -2, and -4 as well as tenascin-C and -X secreted protein acidic and rich in cysteine (SPARC), osteopontin, periostin, and members of the CCN family (including CCN1 and CCN2/connective tissue growth factor) are involved in a variety of cardiac pathophysiological conditions, including myocardial infarction, cardiac hypertrophy and fibrosis, aging-associated myocardial remodeling, myocarditis, diabetic cardiomyopathy, and valvular disease.
Atrial expression of the CCN1 and CCN2 proteins in chronic heart failure.
Winnicka et al., Białystok, Poland. In Folia Histochem Cytobiol, 2011
It conclude that in the murine atria, CCN1 and CCN2 proteins are expressed constitutively. In chronic heart failure, CCN proteins tend to be upregulated, which may be related to the action of angiotensin II.
Cyr61/CCN1 is regulated by Wnt/β-catenin signaling and plays an important role in the progression of hepatocellular carcinoma.
Si et al., Chongqing, China. In Plos One, 2011
Over-expression of Cyr61 was positively correlated with increased levels of beta-catenin in human HCC samples.
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.
Lau et al., Chicago, United States. In Nat Cell Biol, 2010
We show that the matricellular protein CCN1 (also known as CYR61; cysteine-rich protein 61), which is dynamically expressed at sites of wound repair, can induce fibroblast senescence by binding to integrin alpha(6)beta(1) and the heparan sulphate proteoglycans (receptors involved in cell adhesion).
CCN proteins: multifunctional signalling regulators.
Perbal, Paris, France. In Lancet, 2004
The CCN (cyr61, ctgf, nov) proteins are an important family of matricellular regulatory factors involved in internal and external cell signalling.
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta.
De Robertis et al., Riverside, United States. In Nat Cell Biol, 2002
It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins.
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