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Cytochrome P450, family 4, subfamily Z, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CYP2U1, PI3K, CYP4X1, CYP1B1, Akt
Papers on CYP4Z1
The 3'UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1.
Xi et al., Nanjing, China. In Breast Cancer Res Treat, Feb 2015
The aim of this study was to investigate the roles of the pseudogene CYP4Z2P-3'UTR and functional gene CYP4Z1-3'UTR in breast cancer angiogenesis process.
Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer.
Yang et al., Wuhan, China. In Toxicol Appl Pharmacol, 2012
CYP4Z1 overexpression promotes tumor angiogenesis and growth in breast cancer partly via PI3K/Akt and ERK1/2 activation
A search for reliable molecular markers of prognosis in prostate cancer: a study of 240 cases.
Mair et al., La Mesa, United States. In Am J Clin Pathol, 2012
By univariable analysis 4 of 20 antibodies (STMN1/stathmin 1, CYP4Z1/cytochrome p450-4z1, CDH1/E-cadherin, and Hey2), Gleason score, perineural invasion, and apical involvement were statistically significant outcome predictors for biopsy tissue.
Profiling the expression of cytochrome P450 in breast cancer.
Heys et al., Aberdeen, United Kingdom. In Histopathology, 2010
CYP4V2 (P = 0.01), CYP4X1 (P = 0.01) and CYP4Z1 (P = 0.01) showed correlations with tumour grade.
Identification of genes associated with non-small-cell lung cancer promotion and progression.
Tanic et al., Belgrade, Serbia. In Lung Cancer, 2010
CYP4Z1, KIR and RDH10 could play a role in non-small-cell lung cancer progression
Gene expression profiling reveals new aspects of PIK3CA mutation in ERalpha-positive breast cancer: major implication of the Wnt signaling pathway.
Bi├Ęche et al., Saint-Cloud, France. In Plos One, 2009
PIK3CA mutations were associated with over-expression of several genes involved in the Wnt signaling pathway (WNT5A, TCF7L2, MSX2, TNFRSF11B), regulation of gene transcription (SEC14L2, MSX2, TFAP2B, NRIP3) and metal ion binding (CYP4Z1, CYP4Z2P, SLC40A1, LTF, LIMCH1).
Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.
Bureik et al., Saarbr├╝cken, Germany. In Biol Chem, 2009
CYP4Z1-dependent in-chain hydroxylation of lauric and myristic acid, which in both cases leads to the formation of four different monohydroxylated products at positions omega-2, omega-3, omega-4, and omega-5, respectively
Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells.
Runge-Morris et al., Tallahassee, United States. In Chem Biol Interact, 2006
Using non-quantitative reverse transcription-polymerase chain reaction (RT-PCR), transcripts for CYP1B1, CYP2J2, CYP2R1, CYP2U1, CYP2W1, CYP4B1, CYP4F, CYP4V2, CYP4X1 and CYP4Z1 were detected in both sub-confluent and confluent MCF10A cells.
Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
Murray et al., United Kingdom. In Clin Cancer Res, 2005
RESULTS: In primary ovarian cancer, several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP2R1, CYP2U1, CYP3A5, CYP3A7, CYP3A43, CYP4Z1, CYP26A1, and CYP51) were present at a significantly higher level of intensity compared with normal ovary.
Conditional regulation of the human CYP4X1 and CYP4Z1 genes.
Johnson et al., Los Angeles, United States. In Arch Biochem Biophys, 2005
PPARalpha has a role in CYP4X1 regulation, and the glucocorticoid and progesterone receptors have roles in CYP4Z1 gene activation
Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.
Weigle et al., Dresden, Germany. In Cancer Res, 2004
Human cytochrome P450 (CYP), termed CYP4Z1,was identified, and the cDNA was cloned from a breast carcinoma line .
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