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Cytochrome P450, family 3, subfamily A, polypeptide 43

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CYP3A4, CYP3A7, AGE, HAD, iMpact
Papers on CYP3A43
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
Thorne et al., Melbourne, Australia. In Urol Oncol, Dec 2015
In addition, 3 truncating variants, CYP3A43, DOK3, and PLEKHH3, demonstrated complete segregation and 3 truncation mutations, HEATR5B, GPR124, and HKR1, demonstrated partial segregation with PC.
Association between cytochrome CYP17A1, CYP3A4, and CYP3A43 polymorphisms and prostate cancer risk and aggressiveness in a Korean study population.
Myung et al., Seoul, South Korea. In Asian J Androl, Mar 2015
In this study, we evaluated genetic variants of the androgen metabolism genes CYP17A1, CYP3A4, and CYP3A43 to determine whether they play a role in the development of prostate cancer (PCa) in Korean men.
Genetic variation in CYP3A43 is associated with response to antipsychotic medication.
Müller et al., Toronto, Canada. In J Neural Transm, 2015
Recently, the rs472660 variant in CYP3A43 has been associated with olanzapine response and clearance.
DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma.
Friso et al., Verona, Italy. In Clin Epigenetics, 2014
Notably, promoter DNA methylation emerged as a novel regulatory mechanism for the transcriptional repression of genes controlling the retinol metabolism (ADH1A, ADH1B, ADH6, CYP3A43, CYP4A22, RDH16), iron homeostasis (HAMP), one-carbon metabolism (SHMT1), and genes with a putative, newly identified function as tumor suppressors (FAM107A, IGFALS, MT1G, MT1H, RNF180).
Mutational landscape of candidate genes in familial prostate cancer.
Cooney et al., Ann Arbor, United States. In Prostate, 2014
Four missense variants, BLM Gln123Arg, PARP2 Arg283Gln, LRCC46 Ala295Thr and KIF2B Pro91Leu, and one nonsense variant, CYP3A43 Arg441Ter, showed complete co-segregation with PCa status.
Steroidogenic germline polymorphism predictors of prostate cancer progression in the estradiol pathway.
Guillemette et al., Québec, Canada. In Clin Cancer Res, 2014
Specifically, we examined 71 single-nucleotide polymorphisms (SNP) in SULT2A1, SULT2B1, CYP1B1, COMT, CYP3A4, CYP3A5, CYP3A43, NQO1, and NQO2 and assessed the impact of the SNPs alone and in combination on prostate cancer progression and on circulating hormone levels.
No influence of CYP3A43 rs472660G> A on steady-state serum olanzapine concentrations in white psychiatric patients.
Dahl et al., Huddinge, Sweden. In Pharmacogenet Genomics, 2014
The potential involvement of CYP3A43 in systemic olanzapine (OLA) metabolism has been suggested by one reported association between the intronic polymorphism CYP3A43 rs472660G>A and OLA clearance in 235 White and African-American patients.
Vitamin D receptor agonist EB1089 is a potent regulator of prostatic "intracrine" metabolism.
Thompson et al., Coleraine, United Kingdom. In Prostate, 2014
Real-Time PCR analysis revealed that VDR mediated significant regulation of CYP3A4, CYP3A5, CYP3A43, AKR1C1-3, UGT2B15/17, and HSD17B2.
Cytochrome P450 genetic polymorphism in neonatal drug metabolism: role and practical consequences towards a new drug culture in neonatology.
Fanos et al., Cagliari, Italy. In Int J Immunopathol Pharmacol, 2014
The human cytochrome P450 3A gene family (CYP3A) accounts for the largest portion of CYP450 proteins in human liver and includes 4 genes: CYP3A4, CYP3A5, CYP3A7, CYP3A43.
Pharmacogenetics of olanzapine metabolism.
Dahl et al., Huddinge, Sweden. In Pharmacogenomics, 2013
The potential involvement of FMO1 and CYP3A43 in olanzapine disposition has also been suggested but needs future validation.
Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial deletion of 7q (7q22.1→q31.1).
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation and the consequence of haploinsufficiency of ZKSCAN5, ARPC1A, CYP3A43, RELN, LAMB1, IMMP2L and DOCK4 in this case.
Relationship of early-onset baldness to prostate cancer in African-American men.
Rebbeck et al., Philadelphia, United States. In Cancer Epidemiol Biomarkers Prev, 2013
We determined age-stratified associations of baldness with prostate cancer occurrence and severity defined by high stage (T3/T4) or high grade (Gleason 7+.) Associations of androgen metabolism genotypes (CYP3A4, CYP3A5, CYP3A43, AR-CAG, SRD5A2 A49T, and SRD5A2 V89L), family history, alcohol intake, and smoking were examined by baldness status and age group by using multivariable logistic regression models.
The frameshift polymorphism CYP3A43_74_delA is associated with poor differentiation of breast tumors.
GENICA Network et al., Stuttgart, Germany. In Cancer, 2011
No differences in genotype frequencies between cases and controls were observed, indicating that CYP3A43_74_delA is not associated with breast cancer risk.
Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia.
Lyakhovich et al., Novosibirsk, Russia. In Bull Exp Biol Med, 2005
analysis of the restriction fragment length polymorphism CYP3A43 gene c1047 > T in europeoid residents of West Siberia
Significance of the minor cytochrome P450 3A isoforms.
Daly, Newcastle upon Tyne, United Kingdom. In Clin Pharmacokinet, 2005
Cytochrome P450 (CYP) 3A4 is responsible for most CYP3A-mediated drug metabolism but the minor isoforms CYP3A5, CYP3A7 and CYP3A43 also contribute.
The human genome project and novel aspects of cytochrome P450 research.
Ingelman-Sundberg, Stockholm, Sweden. In Toxicol Appl Pharmacol, 2005
Among the genes discovered by initiatives in the human genome project are CYP2R1, CYP2W1, CYP2S1, CYP2U1 and CYP3A43, the latter apparently encoding a pseudoenzyme.
CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians.
Lang et al., United States. In Cancer Epidemiol Biomarkers Prev, 2005
Finds CYP3A43-Pro(340)Ala polymorphism prevalence differs by race and contributes to prostate cancer risk in African Americans.
Regulation of CYP3A genes in the human respiratory tract.
Pelkonen et al., Kuopio, Finland. In Chem Biol Interact, 2005
The CYP3A gene cluster consists of four members, CYP3A4, CYP3A5, CYP3A7 and CYP3A43.
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