gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cytochrome P450, subfamily 2, polypeptide 11

CYP2C11, P-450h
most abundant member of the p450 xenobiotic-inducible superfamily in non-stimulated liver; metabolizes xenobiotics and testosterone [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Cyp, CYP1A1, CYP3A2, CYP3A4, CYP2B1
Papers on CYP2C11
Epoxyeicosatrienoic acid analog mitigates kidney injury in a rat model of radiation nephropathy.
Cohen et al., Milwaukee, United States. In Clin Sci (lond), Feb 2016
The kidney expression of the EET producing enzyme CYP2C11 was lower in rats that received total body irradiation (TBI rat) compared to non-irradiated control.
Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450.
Daniel et al., Kraków, Poland. In Biochem Pharmacol, Feb 2016
Intracerebral injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine affected serum hormone concentration and increased the expression and activity of the hormone-dependent isoforms CYP1A1/2, CYP2C11 and CYP3A1.
Influences of Re Du Ning Injection, a traditional Chinese medicine injection, on the CYP450 activities in rats using a cocktail method.
Xiao et al., Nanjing, China. In J Ethnopharmacol, Dec 2015
AIM OF THE STUDY: To elucidate the potential influences of RDN on the activities of four cytochrome P450 (CYP) isozymes in rats (CYP1A2, CYP2C11, CYP2D1 and CYP3A1/2) by "cocktail method".
Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis.
Sakaki et al., Toyama, Japan. In Pharmacol Res Perspect, Oct 2015
Additionally, we observed a similar MBI of CYP2C by sesamin in the rat liver microsomes.
Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats.
Li et al., Wuhan, China. In J Thorac Dis, Oct 2015
In addition, real-time RT-PCR was used to analyze the mRNA expression of CYP1A2, CYP2C11, CYP2E1 and CYP3A1 in rat liver.
In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity using LC-MS/MS.
Wang et al., Shanghai, China. In Sci China Life Sci, Oct 2015
UNASSIGNED: This study explored the effects of cucurbitacin E (CuE), a bioactive compound from Cucurbitaceae, on the metabolism/pharmacokinetic of tolbutamide, a model CYP2C9/11 probe substrate, and hepatic CYP2C11 expression in rats.
[Effect of Gegen Qinlian decoction on hepatic cytochrome CYP450 isozymes in rats by HPLC-MS/MS].
Wang et al., In Zhongguo Zhong Yao Za Zhi, Aug 2015
Gegen Qinlian decoction showed different degrees of inhibitor effect on 5 CYP450 isoforms (CYP1A2, CYP2C11, CYP2D2, CYP2E1, CYP3A1/2).
[Interaction of butylphthalide with rat and human liver CYP450 isoenzymes].
Hu et al., In Yao Xue Xue Bao, May 2015
After adding the specific inhibitors of CYP2C11, 2E1 and 3A 1/2 for rat, CYP2C19, 2E1 and 3A4/5 for human, the metabolism of NBP in rat and human liver microsomes were reduced 38.8%,
Can bioactive compounds of Crocus sativus L. influence the metabolic activity of selected CYP enzymes in the rat?
Zendulka et al., Brno, Czech Republic. In Physiol Res, 2014
The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM).
The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method.
Zheng et al., Wenzhou, China. In Biomed Res Int, 2014
In order to investigate the effects of MGCD0103 on the metabolic capacity of cytochrome P450 (CYP) enzymes, a cocktail method was employed to evaluate the activities of human CYP2B1, CYP1A2, CYP2C11, CYP2D6, CYP3A4, and CYP2C9.
Stress is a critical player in CYP3A, CYP2C, and CYP2D regulation: role of adrenergic receptor signaling pathways.
Konstandi et al., Ioánnina, Greece. In Am J Physiol Endocrinol Metab, 2012
Data suggest liver Cyp2c11 is induced by stress; Cyp2c11 is induced by physical restraint/maternal deprivation (responders only); epinephrine/corticosterone induce Cyp2c11 in primary hepatocytes. Cyp2c11 induction is modulated by adrenergic agonists.
Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?
DeLuca et al., Madison, United States. In Arch Biochem Biophys, 2012
Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.
The role of the nervous system in the regulation of liver cytochrome p450.
Daniel et al., Kraków, Poland. In Curr Drug Metab, 2011
It has been shown that changes in the brain monoaminergic systems affect liver cytochrome P450 (CYP) expression (CYP1A, CYP2B, CYP2C11 and CYP3A).
The brain dopaminergic system as an important center regulating liver cytochrome P450 in the rat.
Daniel et al., Kraków, Poland. In Expert Opin Drug Metab Toxicol, 2009
This paper reviews evidence that changes in the functioning of the brain dopaminergic system affect liver cytochrome P450 (CYP) expression (CYP1A, CYP2B, CYP2C11 and CYP3A in the case of the tuberoinfundibular pathway or CYP1A and CYP3A in the case of the mesolimbic pathway), as well as blood plasma concentration of the respective pituitary hormones in the rat.
Role of NF-kappaB in the regulation of cytochrome P450 enzymes.
El-Kadi et al., Edmonton, Canada. In Curr Drug Metab, 2009
First, NF-kappaB can directly regulate the expression of CYP1A1, CYP2B1/2, CYP2C11, CYP2D5, CYP2E1, CYP3A7, and CYP27B1 through binding to the promoter region of these genes.
Effect of hemodialysis on hepatic cytochrome P450 functional expression.
Pichette et al., Canada. In J Pharmacol Sci, 2008
Report effect of hemodialysis on hepatic cytochrome CYP2c11 functional expression.
The role of cytochrome p-450 in salt-sensitive stroke in stroke-prone spontaneously hypertensive rats.
Nara et al., Okayama, Japan. In Hypertens Res, 2008
CYP2C11 plays an important role in regulating cerebral blood flow and, as a result, in preventing stroke in the salt-sensitive stroke-prone SHRSP/Izm rats
Growth hormone (GH) secretion, GH-dependent gene expression, and sexually dimorphic body growth in young rats with chronic renal failure.
Gil et al., Richmond, United States. In Endocrine, 2008
Expression of liver P450 CYP2C11 mRNA, which is dependent upon the male GH pattern, became undetectable, whereas expression of liver P450 CYP2C12 mRNA, which is dependent upon the female GH pattern, increased multifold in chronic renal failure
Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection.
Croyle et al., Austin, United States. In Virol J, 2007
Wild type adenovirus suppressed CYP3A2 and CYC2C11 gene expression during infection.
Pharmacokinetic changes of drugs in rat model of acute renal failure induced by uranyl nitrate: correlation between drug metabolism and hepatic microsomal cytochrome P450 isozymes.
Oh et al., Seoul, South Korea. In Curr Clin Pharmacol, 2006
In male Sprague-Dawley rat model of acute renal failure induced by uranyl nitrate (rat model of U-ARF), the expression of CYP2C11 decreased by 20% of control, whereas that of CYP2E1 and 3A1(23) increased 2-4 and 4 times, respectively, as compared with controls.
share on facebooktweetadd +1mail to friends