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Cytochrome P450, family 26, subfamily A, polypeptide 1

CYP26A1, CYP26, CP26, P450RAI
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, CYP26B1, Tec, HAD
Papers on CYP26A1
CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition.
Ho et al., Chicago, United States. In Dev Biol, Feb 2016
Using chemical inhibitors to alter RA concentrations and morpholinos to knock-down Cdx4 function in zebrafish, we show that Cdx4 acts to prevent RA degradation in the presumptive spinal cord domain by suppressing expression of the RA degradation enzyme, Cyp26a1.
Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish, Silurus meridionalis.
Wang et al., Chongqing, China. In Gen Comp Endocrinol, Feb 2016
To explore the existence of stra8-dependent pathway in RA mediated meiotic initiation in fishes, in the present study, the genes encoding RA synthase aldh1a2 and catabolic enzyme cyp26a1 and cyp26b1 were cloned from the Southern catfish.
Retinoid Homeostatic Gene Expression in Liver, Lung and Kidney: Ontogeny and Response to Vitamin A-Retinoic Acid (VARA) Supplementation from Birth to Adult Age.
Ross et al., United States. In Plos One, Dec 2015
VARA supplementation increased total retinol in plasma, liver and lung, with a dose-by-dose accumulation in neonatal liver and lung, while transcripts for Lrat in liver, megalin in kidney, Cyp26A1/B1 in liver and lung, respectively, and Stra6 in lung, were all increased, suggesting pathways of VA uptake, storage and RA oxidation were each augmented after VARA.
Dietary vitamin A supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders.
Fan et al., Guangzhou, China. In Poult Sci, Dec 2015
Supplemental 21,600 IU/kg VA increased cytochrome P450 26A1 (CYP26A1) transcripts in the ovarian stroma and the walls of white follicles (P < 0.05).
Cytochrome P450 oxidoreductase deficiency: rare congenital disorder leading to skeletal malformations and steroidogenic defects.
Ogata et al., Tokyo, Japan. In Pediatr Int, 2014
PORD is caused by homozygous or compound heterozygous mutations in POR encoding an electron donor for several microsomal enzymes such as CYP21A2, CYP17A1, CYP19A1, CYP51A1, and CYP26A1-C1.
Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer.
Isoherranen et al., Seattle, United States. In Adv Pharmacol, 2014
Concentrations of atRA are tightly regulated in tissues, predominantly by the availability of retinol, synthesis of atRA by ALDH1A enzymes and metabolism and clearance of atRA by CYP26 enzymes.
Structure and dynamics of thylakoids in land plants.
Leister et al., Martinsried, Germany. In J Exp Bot, 2014
Stacking of grana is thought to be due to adhesion between Lhcb proteins (LHCII or CP26) located in opposed thylakoid membranes.
Architecture and function of plant light-harvesting complexes II.
Chang et al., Beijing, China. In Curr Opin Struct Biol, 2013
Besides, three minor species, named CP29, CP26 and CP24, are adjacent to the PSII core, exist in monomeric form and bridge the majLHCII trimers with the core complex.
Therapeutic potential of the inhibition of the retinoic acid hydroxylases CYP26A1 and CYP26B1 by xenobiotics.
Isoherranen et al., Seattle, United States. In Curr Top Med Chem, 2012
Since the initial identification of inhibitors of RA metabolism, CYP26 enzymes have been characterized as the main enzymes responsible for RA clearance.
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.
Zhu et al., Beijing, China. In Science, 2012
In mouse embryonic stem cells, local chromatin compaction occurs before the formation of trimethylated H3K27 upon transcription cessation of the retinoic acid-regulated gene CYP26a1.
Identification and characterization of a novel retinoic acid response element in zebrafish cyp26a1 promoter.
Zhao et al., Nanjing, China. In Anat Rec (hoboken), 2012
Zebrafish cyp26a1 promoter contains a novel retinoic acid response element that plays crucial roles in regulating its expression during early development.
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases.
Isoherranen et al., Seattle, United States. In Biochem Pharmacol, 2012
CYP26A1 and CYP26B1 are qualitatively similar retinoic acid hydroxylases with overlapping expression profiles; CYP26A1 has higher catalytic activity than CYP26B1.
Enhanced expression of retinoic acid-metabolizing enzyme CYP26A1 in sunlight-damaged human skin.
Lee et al., Kōchi, Japan. In Med Mol Morphol, 2011
Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional vitamin A deficieny state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis
xCOUP-TF-B regulates xCyp26 transcription and modulates retinoic acid signaling for anterior neural patterning in Xenopus.
Michiue et al., Tokyo, Japan. In Int J Dev Biol, 2011
Results suggest that xCOUP-TF and xCyp26 are both regulated by Wnt signaling, and cooperatively function in retinoic acid (RA) signaling to affect anterior-posterior (A-P) neural patterning.
Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma.
Greally et al., Salamanca, Spain. In Epigenetics, 2011
The promoter region of CYP26A1 is significantly hypermethylated in allergic asthmatic subjects.
Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1).
Eriksson et al., Örebro, Sweden. In J Chem Theory Comput, 2008
Homology models of cytochrome P450 26A1 and cytochrome P450 26B1 were constructed using the crystal structures of human, CYP2C8, CYP2C9, and CYP3A4 as templates for the model building.
Architecture of a charge-transfer state regulating light harvesting in a plant antenna protein.
Fleming et al., Berkeley, United States. In Science, 2008
We found evidence for charge-transfer quenching in all three of the individual minor antenna complexes of PSII (CP29, CP26, and CP24), and we conclude that charge-transfer quenching in CP29 involves a delocalized state of an excitonically coupled chlorophyll dimer.
Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.
Ibbotson et al., Dundee, United Kingdom. In Lancet, 2003
We showed that all-trans retinoic acid is metabolised by CYP2S1, which has higher cutaneous expression than CYP26, previously described as the specific cutaneous P450 retinoic-acid-metabolising enzyme.
Plants lacking the main light-harvesting complex retain photosystem II macro-organization.
Horton et al., Sheffield, United Kingdom. In Nature, 2003
The place of LHCII is taken by a normally minor and monomeric complex, CP26, which is synthesized in large amounts and organized into trimers.
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development.
Dollé et al., France. In Nat Genet, 2002
Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes mimicking those generated by excess retinoic acid administration.
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