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Cytochrome P450, family 1, subfamily B, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CYP1A1, aryl hydrocarbon receptor, Cyp, CAN, HAD
Papers using CYP1B1 antibodies
The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma
Rosengren R J et al., In British Journal of Cancer, 2005
... Matrigel and the primary antibodies Akt, pAkt, EGFR, pEGFR and CYP1B1 were purchased from BD Biosciences (Auckland, New Zealand) ...
Effects of α-substitutions on structure and biological activity of anticancer chalcones
Potter Gerry A et al., In Breast Cancer Research : BCR, 2005
... The primary antibodies to detect CYP1A (both CYP1A1 and CYP1A2) and CYP1B1 were obtained from Gentest Corporation (now part of BD Biosciences, San Jose, CA, USA), ...
Papers on CYP1B1
Candidate genes involved in the susceptibility of primary open angle glaucoma.
Kaur et al., New Delhi, India. In Gene, Mar 2016
Also, the role of Cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), Glutathione S-transferase mu 1 (GSTM1) and Neurotrophin (NTF4) has been fairly identified.
Testing of candidate single nucleotide variants associated with paclitaxel neuropathy in the trial NCCTG N08C1 (Alliance).
Beutler et al., Rochester, United States. In Cancer Med, Feb 2016
The rs10509681 and rs11572080 in the gene CYP2C8*3 showed risk effect with an OR = 1.49 and rs1056836 in CYP1B1 showed a protective effect with an OR = 0.66.
Whole-exome sequencing reveals potential molecular predictors of relapse after discontinuation of the targeted therapy in chronic myeloid leukemia patients.
Kutsev et al., Moscow, Russia. In Leuk Lymphoma, Feb 2016
We found variants in genes CYP1B1, ALPK2, and IRF1 in group of patients with relapse and one variant in gene PARP9 in group of patients without relapse.
Lycopene protects against atrazine-induced hepatotoxicity through modifications of cytochrome P450 enzyme system in microsomes.
Zhang et al., Harbin, China. In Exp Toxicol Pathol, Feb 2016
LYC modulated the contents and activities of CYP450s and normalized the expressions of four CYP450s genes (CYP1b1, CYP2a4, CYP2e1, and 4A14).
CYP1B1 inhibition attenuates Doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism.
El-Kadi et al., Edmonton, Canada. In Pharmacol Res, Feb 2016
Furthermore, several studies have suggested a role for cytochrome P450 1B1 (CYP1B1) and mid-chain hydroxyeicosatetraenoic acids (mid-chain HETEs) in DOX-induced cardiac toxicity.
The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy.
El-Kadi et al., Edmonton, Canada. In Arch Toxicol, Jan 2016
Mid-chain HETEs are biologically active eicosanoids that result from the metabolism of arachidonic acid (AA) by both lipoxygenase and CYP1B1 (lipoxygenase-like reaction).
2-Amino-2-deoxy-glucose conjugated cobalt ferrite magnetic nanoparticle (2DG-MNP) as a targeting agent for breast cancer cells.
Güray et al., Ankara, Turkey. In Environ Toxicol Pharmacol, Jan 2016
In addition, the gene expression levels of four drug-metabolizing enzymes, two Phase I (CYP1A1, CYP1B1) and two Phase II (GSTM3, GSTZ1) were also increased with the high concentrations of 2DG-MNPs.
Role of Metabolic Enzymes P450 (CYP) on Activating Procarcinogen and their Polymorphisms on the Risk of Cancers.
Feng et al., Tianjin, China. In Curr Drug Metab, 2014
1) Formation of epoxide and diol-epoxides intermediates, such as CYP1A1 and CYP1B1 mediates PAHs oxidation to epoxide intermediates; 2) Formation of diazonium ions, such as CYP2A6, CYP2A13 and CYP2E1 mediates activation of most nitrosamines to unstable metabolites, which can rearrange to give diazonium ions.
Primary congenital glaucoma.
Khaw et al., London, United Kingdom. In Prog Brain Res, 2014
PCG is more common in populations with a higher prevalence of consanguinity and is associated with CYP1B1 gene mutations which show variable expressivity and phenotypes.
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis.
Lin et al., Jinan, China. In Genet Mol Res, 2014
Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients.
Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors of menopausal hot flashes.
Flaws et al., Urbana, United States. In Am J Obstet Gynecol, 2012
CYP1B1 is associated with menopausal hot flashes via pathways that may involve changes in serum estradiol concentration
Activity of the estrogen-metabolizing enzyme cytochrome P450 1B1 influences the development of pulmonary arterial hypertension.
MacLean et al., Glasgow, United Kingdom. In Circulation, 2012
CYP1B1-mediated estrogen metabolism promotes the development of pulmonary arterial hypertension, likely via the formation of mitogens, including 16alpha-hydroxyestrone.
Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands.
Gil et al., Faro, Portugal. In Trop Med Int Health, 2012
Cytochrome 1B1 and gene diversity in the Zanzibar islands
Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women.
Rebbeck et al., Philadelphia, United States. In J Clin Endocrinol Metab, 2012
European-American CYP 1B1*3 double-variant carriers who smoked described more frequent moderate or severe hot flashes than nonsmoking.
No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis.
Xu et al., Changsha, China. In Mol Vis, 2011
The cumulative effect of genetic polymorphisms in CYP1B1 is not associated with primary open-angle glaucoma (Meta-analysis).
Role of CYP1B1 in glaucoma.
Gonzalez et al., Denver, United States. In Annu Rev Pharmacol Toxicol, 2007
CYP1B1-deficient mice exhibit abnormalities in their ocular drainage structure and trabecular meshwork that are similar to those reported in human PCG patients [review]
Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer.
Brown et al., Saint Louis, United States. In J Clin Oncol, 2007
PATIENTS AND METHODS: We assessed 27 selected polymorphisms based on previously described associations or putative functional effects in 16 key genes from pathways that may influence cellular sensitivity to taxanes (ABCB1, ABCC1, ABCC2, ABCG2, CDKN1A, CYP1B1, CYP2C8, CYP3A4, CYP3A5, MAPT, and TP53) and platinum (ABCC2, ABCG2, ERCC1, ERCC2, GSTP1, MPO, and XRCC1) using polymerase chain reaction and Pyrosequencing in 914 ovarian cancer patients from the Scottish Randomised Trial in Ovarian Cancer phase III trial who were treated at presentation with carboplatin and taxane regimens after cytoreductive surgery.
Combination of polymorphisms from genes related to estrogen metabolism and risk of prostate cancers: the hidden face of estrogens.
Cancel-Tassin et al., Paris, France. In J Clin Oncol, 2007
Modification of ocular defects in mouse developmental glaucoma models by tyrosinase.
John et al., Bar Harbor, United States. In Science, 2003
Mutations in the cytochrome P450 family 1, subfamily B, polypeptide 1 (CYP1B1) gene are a common cause of human primary congenital glaucoma (PCG).
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
Kaminsky et al., Albany, United States. In Annu Rev Pharmacol Toxicol, 2002
Many CYPs are expressed in one or more of these organs, including CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2A13, CYP2B6, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP2S1, CYP3A4, CYP3A5, and CYP4B1.
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