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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cyclin T2

cyclin T2a, cyclin T2, CycT2, cyclin T2b
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: PCNA, TAK, POLYMERASE, cyclin T1, V1a
Papers using cyclin T2a antibodies
Detection and quantification of phosphotyrosine in proteins
Nekhai Sergei et al., In Retrovirology, 1982
... Antibodies for CDK2, CDK9, cyclin T1 and cyclin T2 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on cyclin T2a
AMACR amplification in myxofibrosarcomas: a mechanism of overexpression that promotes cell proliferation with therapeutic relevance.
Huang et al., Tainan City, Taiwan. In Clin Cancer Res, 2015
In myxofibrosarcoma cell lines, stable AMACR knockdown suppressed cell proliferation, anchorage-independent growth, and expression of cyclin D1 and cyclin T2.
Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.
Peterlin et al., In J Biol Chem, 2014
The positive transcription elongation factor b (P-TEFb), comprised of cyclin-dependent kinase 9 (CDK9) and cyclins T1 (CycT1) or T2 (CycT2), activates eukaryotic transcription elongation.
Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Peterlin et al., San Francisco, United States. In J Biol Chem, 2014
By phosphorylating negative elongation factors and the C-terminal domain of RNA polymerase II (RNAPII), positive transcription elongation factor b (P-TEFb), which is composed of CycT1 or CycT2 and CDK9, activates eukaryotic transcription elongation.
Activation and function of murine Cyclin T2A and Cyclin T2B during skeletal muscle differentiation.
Bagella et al., Sassari, Italy. In J Cell Biochem, 2013
The regulatory units of Cdk9 are the T family Cyclins (T1, T2) and Cyclin K. Cyclin T2 has two forms termed Cyclin T2a and Cyclin T2b that arise by an alternative splicing of the primary transcript.
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia.
Zhang et al., Beijing, China. In Blood, 2012
Both the miRNAs directly inhibited cyclin T2 gene, preventing the release of hypophosphorylated retinoblastoma and resulting in induction of monocytic differentiation.
Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.
Rice et al., Houston, United States. In Biology (basel), 2011
P-TEFb exists in multiple complexes in cells, and its core consists of a kinase, Cdk9, and a regulatory subunit, either Cyclin T1 or Cyclin T2.
Cyclin T2: a novel miR-15a target gene involved in early spermatogenesis.
Wang et al., Beijing, China. In Febs Lett, 2011
miR-15a inhibited muscle differentiation at least in part by targeting Ccnt2; roles in spermatogenesis.
HSV-1 stimulation-related protein HSRG1 inhibits viral gene transcriptional elongation by interacting with Cyclin T2.
Li et al., Kunming, China. In Sci China Life Sci, 2011
Yeast two-hybrid and immunoprecipitation assays indicated that HSRG1 interacts with Cyclin T2, the regulatory subunit of P-TEFb, which is required for transcription elongation by RNA Pol II (RNAP II), and that amino acid residues 1-420 in Cyclin T2 are important for binding with HSRG1.
Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.
Rice et al., Houston, United States. In Bmc Res Notes, 2010
P-TEFb contains Cdk9 (Cyclin-dependent kinase 9) as its catalytic subunit and is regulated by its Cyclin partners, Cyclin T1 and Cyclin T2.
Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair.
Zhou et al., Beijing, China. In Bmc Biochem, 2010
By means of immunoprecipitation and MALDI-TOF-Mass spectrometric analysis, we have revealed the interaction of DNA-PKcs and cyclin T2, which is a subunit of the human transcription elongation factor (P-TEFb).
Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.
Geyer et al., Dortmund, Germany. In J Mol Biol, 2010
The tripartite protein-RNA complex formation between Hexim, Cyclin T and 7SK snRNA, was analyzed.
Cyclin T2 is essential for mouse embryogenesis.
Peterlin et al., Brno, Czech Republic. In Mol Cell Biol, 2009
despite numerous matings of heterozygous mice, we observed no CycT2(-/-) embryos, pups, or adult mice. This early lethality could have resulted from decreased expression of critical genes
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.
Giordano et al., Philadelphia, United States. In Cell Cycle, 2008
The so-called Cdk9-related pathway comprises two Cdk9 isoforms (Cdk9-42 and Cdk9-55), cyclin T1, cyclin T2a, cyclin T2b and cyclin K.
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
Singer et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2008
TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities
Regulation of P-TEFb elongation complex activity by CDK9 acetylation.
Wong et al., Houston, United States. In Mol Cell Biol, 2007
These results suggest that acetylation of CDK9 is an important posttranslational modification that is involved in regulating P-TEFb transcriptional elongation function.
Involvement of cdks and cyclins in muscle differentiation.
De Luca et al., Napoli, Italy. In Eur J Histochem, 2006
Unlike other cdk/cyclin complexes, overexpression of cdk9/cyclin T2a, enhances MyoD function and promotes myogenic differentiation.
Cyclin T: three forms for different roles in physiological and pathological functions.
Paggi et al., Roma, Italy. In J Cell Physiol, 2003
There are three forms of cyclin T: cyclin T1, cyclin T2a, and T2b.
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