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Cyclin L2

Cyclin L2, CCNL2
The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: PCNA, CAN, bcl-2, SC35, POLYMERASE
Papers on Cyclin L2
Subversion of Cell Cycle Regulatory Mechanisms by HIV.
Kimata et al., Houston, United States. In Cell Host Microbe, Jul 2015
The cell-cycle-related protein Cyclin L2 is also utilized to counter innate immunity.
HIV-1/HIV-2 versus SAMHD1 restriction: a tale of two viruses.
Yu et al., Tianjin, China. In Cell Host Microbe, Feb 2015
In this issue of Cell Host & Microbe, Kyei et al. (2015) report that cyclin L2 enhances HIV-1 infection in macrophages by regulating SAMHD1.
Cyclin L2 is a critical HIV dependency factor in macrophages that controls SAMHD1 abundance.
Ratner et al., Saint Louis, United States. In Cell Host Microbe, Feb 2015
Using a yeast two-hybrid screen, we identified cyclin L2 as a DCAF1-interacting protein required for HIV-1 replication in macrophages.
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
Trembley et al., Minneapolis, United States. In Breast Cancer Res, 2014
RNA expression levels of CDC2L1, CDC2L2, CCNL1, CCNL2, CSNK2A1, CSNK2A2, and CSNK2B genes in breast cancer subtypes were analyzed.
Promoter methylation profiles between human lung adenocarcinoma multidrug resistant A549/cisplatin (A549/DDP) cells and its progenitor A549 cells.
Ji et al., Chongqing, China. In Biol Pharm Bull, 2012
p=0.0099, and p=0.0165), whereas no significant difference was found in that of the other two genes, CCNL2 and BAD (p=0.0594 and p=0.5546).
Cyclic tensile strain upon human mesenchymal stem cells in 2D and 3D culture differentially influences CCNL2, WDR61 and BAHCC1 gene expression levels.
Cartmell et al., Manchester, United Kingdom. In J Mech Behav Biomed Mater, 2012
The main aims of the project were to gain the following novel information: (1) to determine if the genes CCNL2, WDR61 and BAHCC1 are potentially important mechanosensitive genes in monolayer, (2) to determine if these genes showed the same differential expression in a 3D environment (either tethered to RGD or simply encapsulated within a hydrogel (with RGE motif)) and (3) to determine whether the mesenchymal stem cells would survive within the hydrogels over several days whilst enduring dynamic culture.
Effects of morphine on immediate-early gene expression in the striatum of C57BL/6J and DBA/2J mice.
Przewłocki et al., Kraków, Poland. In Pharmacol Rep, 2011
The strain-selective regulation was also demonstrated for cyclin L2 and tPA after an acute morphine injection.
Overexpression of cyclin L2 inhibits growth and enhances chemosensitivity in human gastric cancer cells.
Ba et al., Tianjin, China. In Asian Pac J Cancer Prev, 2011
Cyclin L2 is a novel member of the cyclin family, recently implicated in the regulation of cell cycle progression and/or transcriptional regulation.
Inhibition of proliferation and differentiation and promotion of apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells.
Cao et al., Nanjing, China. In Biochem Biophys Res Commun, 2010
Cyclin L2 (CCNL2) is a novel member of the cyclin gene family.
Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.
Lahti et al., Rennes, France. In J Biol Chem, 2008
CDK11(p110) interacts physically and functionally with cyclin Lalpha and -beta isoforms and SR proteins to regulate splicing.
Characterization of cyclin L1 as an immobile component of the splicing factor compartment.
Becker et al., Aachen, Germany. In Faseb J, 2007
Data show that a green fluorescent protein (GFP) fusion protein of cyclin L1, in contrast to cyclin L2, was not mobile within the nucleus of living COS7 cells.
Overexpression of cyclin L2 induces apoptosis and cell-cycle arrest in human lung cancer cells.
Ba et al., Tianjin, China. In Chin Med J (engl), 2007
The present study aimed to investigate the anti-proliferative effect of cyclin L2, and to define its growth regulatory mechanisms using human lung adenocarcinoma cell line A549.
Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
Fann et al., Taipei, Taiwan. In Mol Cell Biol, 2006
Here, we report that CrkRS interacts with cyclin L1 and cyclin L2, and thus rename it as the long form of cyclin-dependent kinase 12 (CDK12(L)).
Diversification of CDK11 transcripts during chicken testis development and regression.
Mezquita et al., Barcelona, Spain. In Mol Reprod Dev, 2005
CDK11 (cyclin-dependent kinase 11, formerly known as PITSLRE) is a serine/threonine kinase that associates with the cyclin L2 regulatory partner.
Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells.
Cao et al., Shanghai, China. In J Biol Chem, 2004
represents a new member of the cyclin family, which might regulate the transcription and RNA processing of certain apoptosis-related factors
Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.
Becker et al., Aachen, Germany. In J Biol Chem, 2004
characterize cyclin L2 as a highly mobile component of nuclear speckles and suggest that DYRK1A may regulate splicing by phosphorylation of cyclin L2
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