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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cyclin K

cyclin K, CPR4
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, TAK, POLYMERASE, CRK7, CAN
Papers on cyclin K
Structural and Functional Analysis of the Cdk13/Cyclin K Complex.
Geyer et al., Bonn, Germany. In Cell Rep, Feb 2016
We have determined the crystal structure of the transcription kinase Cdk13 and its Cyclin K subunit at 2.0 Å resolution.
Structure of Ctk3, a subunit of the RNA polymerase II CTD kinase complex, reveals a noncanonical CTD-interacting domain fold.
Cramer et al., Göttingen, Germany. In Proteins, Oct 2015
CTDK-I contains the cyclin-dependent kinase Ctk1 (homologous to human CDK9/CDK12), the cyclin Ctk2 (human cyclin K), and the yeast-specific subunit Ctk3, which is required for CTDK-I stability and activity.
Expression profiles of miRNAs and involvement of miR-100 and miR-34 in regulation of cell cycle arrest in Artemia.
Yang et al., Hangzhou, China. In Biochem J, Oct 2015
A functional analysis revealed that miR-100 and miR-34 regulate the cell cycle during diapause entry by targeting polo-like kinase 1 (PLK1), leading to activation of the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase-ribosomal S6 kinase 2 (MEK-ERK-RSK2) pathway and cyclin K, leading to suppression of RNA polymerase II (RNAP II) activity respectively.
Detrimental effect of CO2-driven seawater acidification on a crustacean brine shrimp, Artemia sinica.
Liu et al., Xiamen, China. In Fish Shellfish Immunol, Mar 2015
In addition, the animals subjected to a lower pH level of seawater underwent changes on their gene expressions, including Spätzle, MyD88, Notch, Gram-negative bacteria binding protein, prophenoloxidase, Apoptosis inhibitor 5, Trachealess, Caveolin-1 and Cyclin K.
Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.
Bullock et al., Vancouver, Canada. In Sci Rep, 2014
Structure-function studies show that this activity is dependent on a C-terminal kinase extension, as well as the binding of cyclin K (CycK).
Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages.
Yu et al., Shanghai, China. In Bmc Evol Biol, 2013
With respect to cyclins, cyclin C, H, L, Y subfamilies, and cyclin K and T as a whole subfamily, are generally conserved in animal, fungi, and amoeba Dictyostelium discoideum.
A distinct expression pattern of cyclin K in mammalian testes suggests a functional role in spermatogenesis.
Li et al., Chengdu, China. In Plos One, 2013
Cyclin K was previously thought to associate with CDK9 to regulate gene expression.
CDK9 inhibition strategy defines distinct sets of target genes.
Graña et al., Philadelphia, United States. In Bmc Res Notes, 2013
CDK9 associates with T-type cyclins and cyclin K and its activity is tightly regulated in cells at different levels.
The structure and substrate specificity of human Cdk12/Cyclin K.
Geyer et al., Bonn, Germany. In Nat Commun, 2013
Phosphorylation of the RNA polymerase II C-terminal domain (CTD) by cyclin-dependent kinases is important for productive transcription.
Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.
Kelly et al., Atlanta, United States. In Development, 2013
RNA polymerase II (Pol II) elongation in metazoans is thought to require phosphorylation of serine 2 (Ser2-P) of the Pol II C-terminal domain (CTD) by the P-TEFb complex, CDK-9/cyclin T. Another Ser2 kinase complex, CDK-12/cyclin K, which requires upstream CDK-9 activity has been identified in Drosophila and human cells.
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
Mitra et al., Pune, India. In J Biol Chem, 2011
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
A role for CDK9-cyclin K in maintaining genome integrity.
Cortez et al., Atlanta, United States. In Cell Cycle, 2011
CDK9 also binds to cyclin K but the function of this CDK9-cyclin K complex is less clear.
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.
Cortez et al., Nashville, United States. In Embo Rep, 2010
These results reveal an unexpectedly direct role for CDK9-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress.
Cyclin K and cyclin D1b are oncogenic in myeloma cells.
Sola et al., Caen, France. In Mol Cancer, 2009
Cyclin K-expressing multiple myeloma LP-1 cells have lost their migration properties and display enhanced clonogenic capacities
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.
Giordano et al., Philadelphia, United States. In Cell Cycle, 2008
The so-called Cdk9-related pathway comprises two Cdk9 isoforms (Cdk9-42 and Cdk9-55), cyclin T1, cyclin T2a, cyclin T2b and cyclin K.
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.
Ladias et al., Boston, United States. In J Mol Biol, 2007
The cyclin K fold comprises two typical cyclin boxes with two short helices preceding the N-terminal box. A prominent feature of cyclin K is an additional helix (H4a) in the first cyclin box that obstructs the binding pocket for the p27.
Cellular control of gene expression by T-type cyclin/CDK9 complexes.
Graña et al., Philadelphia, United States. In Gene, 2004
This review is centered on CDK9, which is activated by T-type cyclins and cyclin K generating distinct Positive-Transcription Elongation Factors termed P-TEFb.
CDK9: from basal transcription to cancer and AIDS.
Giordano et al., Siena, Italy. In Cancer Biol Ther, 2002
Its cyclin partners are members of the family of cyclin T (T1, T2a and T2b) and cyclin K.
Cyclin K as a direct transcriptional target of the p53 tumor suppressor.
Arakawa et al., Tokyo, Japan. In Neoplasia, 2002
cyclin K may play a role in regulating the cell cycle or apoptosis
New insight in cdk9 function: from Tat to MyoD.
Giordano et al., Philadelphia, United States. In Front Biosci, 2001
Cdk9 function depends on its kinase activity and also on its regulatory units: the T-family cyclins and cyclin K. Recently, several studies confirmed the role of cdk9 in different cellular processes such as signal transduction, basal transcription, HIV-Tat- and MyoD-mediated transcription and differentiation.
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