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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cyclin E2

cyclin E2, CCNE2
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PCNA, CAN, CDK2, p21, p53
Papers on cyclin E2
E-type cyclins modulate telomere integrity in mammalian male meiosis.
Wolgemuth et al., New York City, United States. In Chromosoma, Jan 2016
Depletion of cyclin E2 reduced fertility in male mice due to meiotic defects, involving abnormal pairing and synapsis, unrepaired DNA, and loss of telomere structure.
Cyclin E1 Inhibition Can Overcome Sorafenib Resistance in Hepatocellular Carcinoma Cells Through Mcl-1 Suppression.
Ou et al., Taiwan. In Clin Cancer Res, Dec 2015
Changes in cyclin E2 or D1 were not correlated with sorafenib sensitivity.
Survivin and cyclin E2 genes expression in a cohort of Egyptian acute leukemia patients: Clinical importance and future prospects.
Makhlouf, In Cancer Biomark, Dec 2015
While, cyclin E2 is one of the cyclins proteins family that controls progression of cell cycle by activation of cyclin dependant-kinase.
Bisdemethoxycurcumin (BDMC) Alters Gene Expression-associated Cell Cycle, Cell Migration and Invasion and Tumor Progression in Human Lung Cancer NCI-H460 Cells.
Chung et al., Fengxian, China. In In Vivo, Dec 2015
RESULTS: Seven genes, such as CCNE2 (cyclin E), associated with cell cycle, were over 4-fold overexpressed, 22 genes, such as ERCC6L (excision repair cross-complementing rodent repair deficiency, complementation group 6-like) associated with DNA damage and repair, were from 3- to 4-fold overexpressed and 266, such as cell division cycle, S-phase associated kinase and associated with cell death, genes were from 2- to 3-fold overexpressed.
Upregulation of miR-34a-5p antagonizes AFB1-induced genotoxicity in F344 rat liver.
Wang et al., Guangzhou, China. In Toxicon, Nov 2015
Upregulation of rno-miR-34a-5p suppressed the expression of the cell cycle-related genes CCND1, CCNE2 and MET and led to cell cycle arrest in the G0-G1 phase.
Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Li et al., Guangzhou, China. In Oncotarget, Nov 2015
We also found that elevated SOSTDC1 led to inhibition of cyclin A2 and cyclin E2.
CDK4/6 Inhibition Controls Proliferation of Bladder Cancer and Transcription of RB1.
Nawroth et al., München, Germany. In J Urol, Sep 2015
Treatment resulted in a decrease in E2F target gene expression (CCNA2 and CCNE2) and cell cycle progression from G0/G1 to the S-phase but did not affect apoptosis.
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line.
Rajam et al., New Delhi, India. In Tumour Biol, Sep 2015
On analyzing the messenger RNA (mRNA) expression profile of the cell cycle and apoptosis-related genes, it was observed that RNAi against PA biosynthetic genes downregulated the expression of CDK8, CCNE2, CCNH, CCNT1, CCNT2, CCNF, PCNA, CCND1, and CDK2, and upregulated the expression of E2F4, BAX, FAS, TP53, CDKN1A, BAK1, CDKN1B, ATM, GRANB, and ATR genes when compared with control-transfected cells.
Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas.
Sun et al., Changchun, China. In Onco Targets Ther, 2014
The genes CCNE2 (also known as cyclin E2), E2F1, RARA, CCND1 (cyclin D1), RUNX1, ITGA2, MET, CDKN1A (p21), and COL4A1 were overexpressed, and AXIN2, TRAF6, BCL2, RARB, HSP90B1, FGF7, and PDGFRA were downregulated.
Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines.
Gong et al., Chengdu, China. In J Orthop Surg Res, 2014
Up-regulated DEGs (including AARS and PARS2) were associated to transfer RNA (tRNA) aminoacylation while down-regulated DEGs (including AURKA, CCNB1, CCNE2, CDK1, and CENPA) were correlated with mitotic cell cycle.
Endocrine resistance in breast cancer.
Liu et al., In Climacteric, 2014
Several molecular mechanisms have been proposed to be responsible for endocrine resistance in breast cancer, including MIR-451, FGF and FGFR, ADAM12, fibronectin and other soluble stromal factors, PELP1-KDM1, HER2, NOTCH, δEF1, mTOR, AKT/mTOR, Pi3K/AKT, Pi3K/AKT/mTOR, NFκB, LMTK3, IGF1R, cyclin E2, IRF1, Tab2, and SRC-1.
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Du et al., Tianjin, China. In Surg Oncol, 2013
The involved genes in the significant gains aberrations include BIRC5, CCNE2, DAB2, DDX15, EGFR, DAB2, MSH2, CDK6, HGF, ITGB4, KCNK12, LAMA3, LOXL2, MET, and PDGFRA.
[Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma].
Miao et al., Pingdingshan, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
protein and mRNA expressions of Cyclin E2 in nasopharyngeal carcinoma
An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.
Dai et al., Chicago, United States. In Plos One, 2010
Tamoxifen resistant tumors displayed enriched expression of genes related to cell cycle and proliferation, as well as elevated activity of E2F transcription factors.
Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Le Beau et al., Chicago, United States. In Chem Biol Interact, 2010
In addition, this subtype of t-AML is characterized by a unique expression profile (higher expression of genes) involved in cell cycle control (CCNA2, CCNE2, CDC2), checkpoints (BUB1), or growth (MYC), loss of expression of IRF8, and overexpression of FHL2.
Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.
Musgrove et al., Australia. In Mol Cell Biol, 2009
Data indicate that cyclin E2-Cdk2 activation by estrogen occurs via E2F- and CHD8-mediated transcription of cyclin E2 downstream of cyclin D1, and does not require c-myc.
Role of E2F1-cyclin E1-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs.
Grassi et al., Italy. In Mol Med, 2009
Investigated downregulation of coronary vascular smooth muscle cell growth by siRNA against E2F1, cyclins E1 and E2. Data shows reduction in the phosphorylation levels of the retinoblastoma protein pRB and a decrease in the amount of cyclin A2.
Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.
Benbrook et al., Oklahoma City, United States. In Cancer Res, 2009
Loss of cyclin D1 in ovarian cancer cells treated with SHetA2 is sufficient to induce G(1) cell cycle arrest and this strategy is not impeded by the presence of cyclin E2.
Cyclin E.
Geisen et al., Essen, Germany. In Int J Biochem Cell Biol, 2004
E-type cyclins (cyclin E1 and cyclin E2) are expressed during the late G1 phase of the cell cycle until the end of the S-phase.
E- and A-type cyclins as markers for cancer diagnosis and prognosis.
Müller-Tidow et al., Münster, Germany. In Expert Rev Mol Diagn, 2003
The second E-type cyclin, cyclin E2, has been shown to be overexpressed in breast cancers although the potential role as a diagnostic or prognostic marker is unknown.
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