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Cyclin D3

cyclin D3, CCND3
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: PCNA, CDK4, p27, p21, CDK6
Papers on cyclin D3
hIgD promotes human Burkitt lymphoma Daudi cell proliferation by accelerated G1/S transition via IgD receptor activity.
Wei et al., Hefei, China. In Immunol Res, Feb 2016
Treatment with hIgD promoted progression of the cell cycle at the G1/S transition, and this was accompanied by upregulation of c-myc, cyclin D3, and CDK6 as well as downregulation of p16 mRNA and protein levels.
Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.
Daw et al., Saint Louis, United States. In Prostate, Jan 2016
RESULTS: Eleven variants within 10 genes (CCNC, CCND3, CCNG1, CCNT2, CDK6, MDM2, SKP2, WEE1, YWHAB, YWHAH) in the European-American population and nine variants in 7 genes (CCNG1, CDK2, CDK5, MDM2, RB1, SMAD3, TERF2) in the African-American population were found to be associated with aggressive PCa using at least one model.
Protein inhibitor of activated STAT xα depresses cyclin D and cyclin D kinase, and contributes to the inhibition of osteosarcoma cell progression.
Ding et al., Changsha, China. In Mol Med Report, Jan 2016
Furthermore, the expression levels of cyclin D1 and cyclin D3 were inhibited following PIAsxα increase, indicating the repressive effects of PIAsxα on cell cycle.
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.
Lee et al., Seoul, South Korea. In Bioorg Med Chem Lett, Jan 2016
This was found to be accompanied by the downregulations of cyclin-dependent kinase (CDK) 2, CDK4, CDK6, cyclin D2, cyclin D3, and cyclin E at the protein levels.
Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.
Cucca et al., Cagliari, Italy. In Nat Genet, Nov 2015
Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3.
Growth Hormone Protects the Intestine Preserving Radiotherapy Efficacy on Tumors: A Short-Term Study.
Santamaria et al., Madrid, Spain. In Plos One, 2014
GH significantly increased proliferation in the irradiated intestine but not in the irradiated tumors, as assessed by Positron Emission Tomography and the proliferative markers Ki67, cyclin D3, and Proliferating Cell Nuclear Antigen.
Oncogenic mechanisms in Burkitt lymphoma.
Staudt et al., Bethesda, United States. In Cold Spring Harb Perspect Med, 2014
Additionally, CCND3 accumulates oncogenic mutations that stabilize cyclin D3 protein expression and drive proliferation.
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Clark et al., Chicago, United States. In Front Immunol, 2013
Remarkably, the principal downstream proliferative effectors of the IL-7R, STAT5 and cyclin D3, directly repress Igκ accessibility through very divergent yet complementary mechanisms.
The requirement for cyclin D function in tumor maintenance.
Sicinski et al., Boston, United States. In Cancer Cell, 2012
Ablation of cyclin D3 in mice bearing Notch1-driven T cell acute lymphoblastic leukemias (T-ALL) triggered tumor cell apoptosis.
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
Aifantis et al., New York City, United States. In Cancer Cell, 2012
Although cyclin D functions appear largely tissue specific, we demonstrate that cyclin D3 has unique functions in lymphocyte development and cannot be replaced by cyclin D2, which is also expressed during blood differentiation.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Staudt et al., Bethesda, United States. In Nature, 2012
In 38% of sporadic BL cases, oncogenic CCND3 mutations produced highly stable cyclin D3 isoforms that drive cell cycle progression.
MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma.
Qi et al., Shanghai, China. In Carcinogenesis, 2012
CCND3 protein expression was observed to be negatively correlated with miR-138 expression in HCC tissues.
Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.
Wagner et al., Omaha, United States. In Cancer Res, 2012
Data show that cyclin D3 is significantly upregulated in breast cancers and frequently exceeds the expression of Cyclin D1 in ErbB2-positive cases.
Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds.
Recio et al., Burjassot, Spain. In Curr Pharm Des, 2011
In general, cucurbitacins are considered to be selective inhibitors of the JAK/STAT pathways; however, other mechanisms may be implicated in their apoptotic effects, including the MAPK pathway (known to be important for cancer cell proliferation and survival), PARP cleavage, expression of active caspase-3, decreased pSTAT3 and JAK3 levels, as well as decreases in various downstream STAT3 targets such as Mcl-1, Bcl-2, Bcl-xL, and cyclin D3, all of which are implicated in apoptosis and the cell cycle.
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.
Sicinski et al., Boston, United States. In Cancer Cell, 2011
Here we performed a systematic screen for substrates of cyclin D1-CDK4 and cyclin D3-CDK6.
The complex landscape of genetic alterations in mantle cell lymphoma.
Beà et al., Barcelona, Spain. In Semin Cancer Biol, 2011
Small subsets of cases have been identified with variant CCND1 translocations with the immunoglobulin light chain genes or with alternative translocations involving CCND2 and CCND3.
Immunohistochemical expression and prognostic significance of CCND3, MCM2 and MCM7 in Hodgkin lymhoma.
Korkolopoulou et al., Athens, Greece. In Anticancer Res, 2011
Lymph node sections from 138 HL patients were immunohistochemically stained for cyclin D3 (CCND3), MCM2 and MCM7 aiming to investigate clinical outcome.
Negative regulation of cyclin D3 expression by transcription factor c-Ets1 in umbilical cord hematopoietic cells.
Liu et al., Wuhan, China. In Acta Pharmacol Sin, 2011
The overexpression of ETS1 could suppress cyclin D3 mRNA and protein levels.
Primary Plasma Cell Leukemia Associated with t(6;14)(p21;q32) and IGH Rearrangement: A Case Study and Review of the Literature.
Park et al., Seoul, South Korea. In Ann Clin Lab Sci, 2010
However, PCL cases associated with t(6;14)(p21;q32) or IGH-CCND3 rearrangement are extremely rare in the literature; only one PCL case with t(6;14) has been documented.
Cyclin D3 gene amplification in bladder carcinoma in situ.
de Alava et al., Córdoba, Spain. In Virchows Arch, 2010
study suggests that Cyclin D3 gene amplification might be a predictor of aggressiveness in BCG-treated bladder urothelial carcinoma in situ
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