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Gap junction protein, beta 1, 32kDa

Cx32, connexin 32, GJB1, CMTX
This gene encodes a member of the gap junction protein family. The gap junction proteins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene cause X-linked Charcot-Marie-Tooth disease, an inherited peripheral neuropathy. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: GAP, Connexin 43, HAD, Cx26, CAN
Papers on Cx32
Connexin32: a mediator of acetaminophen-induced liver injury?
Vinken et al., Brussels, Belgium. In Toxicol Mech Methods, Feb 2016
UNASSIGNED: Connexin32 is the building block of hepatocellular gap junctions, which control direct intercellular communication and thereby act as goalkeepers of liver homeostasis.
Models and methods for in vitro testing of hepatic gap junctional communication.
Vinken et al., Brussels, Belgium. In Toxicol In Vitro, Jan 2016
Hepatic gap junctions, which are mainly built up by connexin32, are specifically targeted by tumor promoters and epigenetic carcinogens.
Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis.
Takahashi et al., Nagoya, Japan. In Oncotarget, Jan 2016
Previous reports indicated that connexin 32 (Cx32), which is a major hepatocyte gap junction protein, is down-regulated in chronic liver disease and has a protective role in hepatocarcinogenesis.
Clinical and genetic spectra in a series of Chinese patients with Charcot-Marie-Tooth disease.
Wang et al., Shanghai, China. In Clin Chim Acta, Jan 2016
The coding regions and splice sites of the GJB1, MPZ, MFN2 and GDAP-1 genes were determined by direct sequencing.
Expression and Localization of Connexins in the Outer Retina of the Mouse.
Janssen-Bienhold et al., Oldenburg, Germany. In J Mol Neurosci, Nov 2015
In addition to connexin36, we detected transcripts for connexin32, connexin43, connexin45, connexin50, and connexin57 in photoreceptor samples.
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more.
Stains et al., Indianapolis, United States. In Cell Mol Life Sci, Aug 2015
Connexin43, connexin45, connexin32, connexin46 and connexin29 are expressed in chondrocytes, while connexin43 and connexin32 are expressed in ligaments and tendons.
Cell communication across gap junctions: a historical perspective and current developments.
Evans, Cardiff, United Kingdom. In Biochem Soc Trans, Jun 2015
GJs purified from liver plasma membranes contained a 27 kDa protein constituent; it was later named Cx32 (connexin 32) after its full sequence was determined by recombinant technology.
Insights into the role of connexins in mammary gland morphogenesis and function.
Laird et al., London, Canada. In Reproduction, Jun 2015
These studies have revealed an important stage-specific role for Cx26 (GJA1) and Cx43 (GJB2), while Cx30 (GJB6) and Cx32 (Gjb1) can be eliminated without compromising the gland.
Hereditary motor and sensory neuropathies or Charcot-Marie-Tooth diseases: an update.
Vallat et al., Algiers, Algeria. In J Neurol Sci, 2015
Although more than seventy clinical and genetic forms are known to date, more than 80% of CMT patients in Western countries have genetic abnormalities associated with PMP22, MPZ, MFN2 and GJB1.
Inhibition of gap junctions relieves the hepatotoxicity of TNF-α.
Li et al., Guangzhou, China. In Genet Mol Res, 2014
Three different methods were employed to study functional effects of the GJ inhibition: 1) pretreatment with a GJ inhibitor; 2) inoculation of cells at high and low densities; and 3) inhibition of the expression of connexin 32 (Cx32) by small inhibitory RNA transfection.
Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study.
van der Knaap et al., Paris, France. In Lancet Neurol, 2013
The remaining paediatric patient had an X-linked family history and a mutation in GJB1, encoding connexin 32.
Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
Sorgen et al., Omaha, United States. In J Biol Chem, 2012
Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM.
SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.
Rosen et al., New York City, United States. In Cardiovasc Res, 2012
Cx32 therapy improves gap junctional conductance results in larger infarct size, and no antiarrhythmic efficacy.
Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
Pérez-Palacios et al., Mexico. In Anat Rec (hoboken), 2012
Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life.
Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure.
Yarmush et al., Boston, United States. In Nat Biotechnol, 2012
We demonstrate that connexin 32 (Cx32), a key hepatic gap junction protein, is an essential mediator of DILI by showing that mice deficient in Cx32 are protected against liver damage, acute inflammation and death caused by liver-toxic drugs.
Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges.
Nagy et al., Winnipeg, Canada. In Eur J Neurosci, 2011
Data show that absence of connexin30 in knockout mice changes the expression patterns of connexin26 and connexin32 in glial cells and leptomeninges.
Mutational analysis of PMP22, GJB1 and MPZ in Greek Charcot-Marie-Tooth type 1 neuropathy patients.
Panas et al., In Clin Genet, 2011
The frequency of mutations in the GJB1 gene in Charcot-Marie-Tooth type 1 patients in the Greek population (4.9%) was similar to frequencies reported in other ethnic populations
Connexin mutations in X-linked Charcot-Marie-Tooth disease.
Fischbeck et al., Philadelphia, United States. In Science, 1994
The gene for the gap junction protein connexin32 is located in the same chromosomal segment, which led to its consideration as a candidate gene for CMTX.
Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage.
Franke et al., Heidelberg, Germany. In Cell, 1993
To examine the potential of cytoplasmic portions ("tails") of desmosomal cadherins for assembly of desmosome plaque structures and anchorage of intermediate filaments (IFs), we transfected cultured human A-431 carcinoma cells, abundant in desmosomes and cytokeratin IFs, with constructs encoding chimeric proteins in which the transmembranous region of connexin 32 had been fused with tails of desmocollin (Dsc) or desmoglein (Dsg).
Formation of gap junctions by expression of connexins in Xenopus oocyte pairs.
Paul et al., Boston, United States. In Cell, 1989
Unexpectedly, connexin43/water oocyte pairs developed high, asymmetrically voltage-dependent conductances, a property not displayed by the connexin32/water pairs.
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