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Gap junction protein, beta 5

Cx31.1, connexin31.1, GJB5
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.[supplied by OMIM, Jul 2008] (from NCBI)
Top mentioned proteins: Cx31, GAP, Connexin 43, Cx26, GJB6
Papers on Cx31.1
Roles of connexins in testis development and spermatogenesis.
Cyr et al., London, Canada. In Semin Cell Dev Biol, Feb 2016
Cx31.1, 32, and 43 have been identified and differentiation of the epithelium is associated with dramatic changes in their expression.
Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299.
Huang et al., Shanghai, China. In J Cell Mol Med, 2015
Connexin 31.1 (Cx31.1)
Restoration of desmosomal junction protein expression and inhibition of H3K9-specific histone demethylase activity by cytostatic proline-rich polypeptide-1 leads to suppression of tumorigenic potential in human chondrosarcoma cells.
Temple et al., Miami, United States. In Mol Clin Oncol, 2015
Among the upregulated proteins were the characteristic for tumors gap junction β-5 protein (connexin 31.1) and the pro-inflammatory pathway protein intercellular adhesion molecule (upregulated 129- and 43-fold, respectively).
Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development.
Lye et al., Toronto, Canada. In Stem Cells Dev, 2014
The gap junction channel forming connexins (Cx) Cx31 (Gjb3) and Cx31.1 (Gjb5) are co-expressed in the mouse trophoblast lineage.
Connexin expression patterns in diseased human corneas.
Tao et al., Guangzhou, China. In Exp Ther Med, 2014
Flow cytometry was adopted to determine the differences in the expression levels of Cx26, Cx31.1 and Cx43.
RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers.
Hagedorn et al., Little Rock, United States. In Plos One, 2013
Marked increased expression of MUC17, the cell junction protein genes VSIG1 and GJB5, and the antiapoptotic gene REG4 were found in SSA/Ps, relative to controls and adenomas, were verified by qPCR analysis of additional SSA/Ps (n = 21) and adenomas (n = 10).
Cx31.1 acts as a tumour suppressor in non-small cell lung cancer (NSCLC) cell lines through inhibition of cell proliferation and metastasis.
Huang et al., Shanghai, China. In J Cell Mol Med, 2012
Overexpression of Cx31.1 in H1299 cells reduced cell proliferation, delayed the G1 phase, inhibited anchorage-independent growth, and suppressed cell migration and invasion. Xenografts of Cx31.1 overexpressing H1299 cells had reduced tumourigenicity.
Expression of connexins and the effect of retinoic acid in oral keratinocytes.
Takeda et al., Japan. In J Oral Sci, 2011
RT-PCR revealed that GE1 cells expressed mRNA for Cx26, Cx30.3, Cx31.1, Cx32, and Cx43.
Antisense down regulation of connexin31.1 reduces apoptosis and increases thickness of human and animal corneal epithelia.
Green et al., Auckland, New Zealand. In Cell Biol Int, 2009
The roles of the gap junction protein connexin31.1 (Cx31.1)
Connexin mutations in Brazilian patients with skin disorders with or without hearing loss.
Sartorato et al., Campinas, Brazil. In Am J Med Genet A, 2009
and GJB5 (Cx31.1),
Expression pattern of connexins in the corneal and limbal epithelium of a primate.
Jacoby et al., Houston, United States. In Cornea, 2009
RESULTS: Transcripts encoding 10 Cx isoforms (Cx26, Cx30, Cx30.3, Cx31, Cx31.1, Cx32, Cx43, Cx45, Cx50, and Cx58) were detected by reverse transcriptase-polymerase chain reaction in both central and peripheral corneal epithelium.
Analogous and unique functions of connexins in mouse and human placental development.
Winterhager et al., Toronto, Canada. In Placenta, 2008
Connexin gene deletion in mice has shown that Cx26 is responsible for transplacental uptake of glucose in the labyrinth, and Cx31 as well as Cx31.1 for trophoblast cell lineage development.
Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex.
Sadile et al., Düsseldorf, Germany. In Neuroscience, 2008
gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of acetylcholine esterase and cAMP response element-binding protein in the striatum and piriform cortex
Characterization of connexin31.1-deficient mice reveals impaired placental development.
Willecke et al., Bonn, Germany. In Dev Biol, 2008
Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse.
Cloning, mapping and mutation analysis of human geneGJB5 encoding gap junction protein beta-5.
Liao et al., Changsha, China. In Sci China C Life Sci, 2001
By homologous EST searching and nested PCR a new human geneGJB5 encoding gap junction protein beta-5 was identified.GJB5 was genetically mapped to human chromosome 1p33-p35 by FISH.
Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis.
Bale et al., Bethesda, United States. In Nat Genet, 1998
Evidence in mouse suggesting that the EKV region harbours a cluster of epidermally expressed connexin genes led us to characterize the human homologues of GJB3 (encoding Cx31) and GJB5 (encoding Cx31.1).
The mouse skin carcinogenesis model.
Aldaz et al., Anderson, United States. In J Investig Dermatol Symp Proc, 1996
In addition, the level and expression of Cx26, Cx43, and Cx31.1 were significantly altered during skin tumor promotion and progression.
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