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Gap junction protein, delta 3, 31.9kDa

Cx30.2, Cx31.9, connexin 30.2, mCx30.2, hCx31.9, GJA11
This gene is a member of the large family of connexins that are required for the formation of gap junctions. Six connexin monomers form a hemichannel, or connexon, on the cell surface. This connexon can interact with a connexon from a neighboring cell, thus forming a channel linking the cytoplasm of the 2 cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: GJB6, GAP, Cx45, Connexin 43, Cx40
Papers on Cx30.2
MyoR modulates cardiac conduction by repressing Gata4.
Munshi et al., Dallas, United States. In Mol Cell Biol, Feb 2015
We identify here MyoR as a novel transcription factor expressed in Cx30.2(+) cells of the AVN.
Connexin evolution ameliorates the risk of various cancers.
Wang et al., Kunming, China. In Eur Rev Med Pharmacol Sci, 2014
RESULTS: When HT1376 bladder cancer cells were transfected with Cx31.9 (Group IV), the growth rate was inhibited by 17%.
Connexin 36, a key element in pancreatic beta cell function.
Pérez-Armendariz, Mexico. In Neuropharmacology, 2013
Co-localization of Cx36 with Cx30.2 has been recently identified.
Genetic isolation of stem cell-derived pacemaker-nodal cardiac myocytes.
Claycomb et al., New Orleans, United States. In Mol Cell Biochem, 2013
Here, we report the use of a SHOX2 promoter and a Cx30.2 enhancer to genetically identify and isolate ES cell-derived sinoatrial node (SAN) and atrioventricular node (AVN) cells, respectively.
Connexin 30.2 is expressed in mouse pancreatic beta cells.
Pérez-Armendariz et al., Mexico. In Biochem Biophys Res Commun, 2013
In the present research we investigated the expression of Cx30.2 mRNA and protein in mouse pancreatic islets.
Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells.
Barbuti et al., Milano, Italy. In Circ Res, 2013
CD166+ cells express high levels of genes involved in SAN development (Tbx18, Tbx3, Isl-1, Shox2) and function (Cx30.2,
High glucose-induced downregulation of connexin 30.2 promotes retinal vascular lesions: implications for diabetic retinopathy.
Roy et al., Boston, United States. In Invest Ophthalmol Vis Sci, 2013
PURPOSE: To investigate whether high glucose (HG) alters expression of connexin 30.2 (Cx30.2) and influences gap junction intercellular communication (GJIC) in retinal endothelial cells and promotes vascular lesions characteristic of diabetic retinopathy (DR).
Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart.
Schrickel et al., Bonn, Germany. In Circ Res, 2013
In addition, the Cx30.2 protein that is coexpressed with Cx45 in the cardiac conduction system was posttranscriptionally reduced by 70% in mutant hearts.
Neurons and β-cells of the pancreas express connexin36, forming gap junction channels that exhibit strong cationic selectivity.
Bukauskas, United States. In J Membr Biol, 2012
In contrast, it is 6.5-fold higher than the P(γ) of mCx30.2, which exhibits a smaller single-channel conductance.
pH-dependent modulation of connexin-based gap junctional uncouplers.
Bukauskas et al., Kaunas, Lithuania. In J Physiol, 2011
We examined pH(i)-dependent modulation of junctional conductance (g(j)) of GJs formed of Cx26, mCx30.2,
Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.
Epstein et al., Philadelphia, United States. In J Clin Invest, 2011
(Cx30.2) and a resulting loss of physiologic AV conduction delay.
Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina.
Weiler et al., Oldenburg, Germany. In Vis Neurosci, 2010
The data of this stiudy provided evidence that coupling of RG A1 cells to displaced amacrine cells is mediated by Cx30.2 and that the extent of this coupling is modulated by protein kinase C.
Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay.
Olson et al., Dallas, United States. In Development, 2009
A distal enhancer for the connexin 30.2 (Cx30.2, also known as Gjd3) gene required for normal atrioventricular (AV) delay in mice, is necessary and sufficient to direct expression to the developing AV conduction system, which is alos dependent on Gata4.
Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.
Willecke et al., Bonn, Germany. In J Mol Cell Cardiol, 2009
Cx30.2 and Cx40 act as counterparts in the AV-node and His-bundle, decreasing or increasing, respectively, electrical coupling and conduction velocity in these areas.
Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system.
Willecke et al., Bonn, Germany. In J Mol Cell Cardiol, 2009
Cx31.9 protein, unlike its counterpart in the mouse, is not expressed in detectable quantities and is thus unlikely to contribute to the impulse generation and conduction system or the working myocardium of the human heart.
[Connexins and junctional channels. Roles in the spreading of cardiac electrical excitation and heart development].
Gros et al., Poitiers, France. In Pathol Biol (paris), 2008
Four Cxs - Cx30.2, -40, -43 and -45--have been demonstrated to be synthesized in the cardiomyocytes.
Cx30.2 can form heteromeric gap junction channels with other cardiac connexins.
Beyer et al., Chicago, United States. In Biochem Biophys Res Commun, 2008
Our data suggest that connexin30.2 can form heteromers with the other cardiac connexins.
Connexin-mediated cardiac impulse propagation: connexin 30.2 slows atrioventricular conduction in mouse heart.
Bukauskas et al., Bonn, Germany. In Trends Cardiovasc Med, 2006
Cx30.2 and its putative human ortholog, Cx31.9, under physiologic conditions form unapposed hemichannels in nonjunctional plasma membrane; these hemichannels have a conductance of approximately 20 pS and are permeable to cationic dyes up to approximately 400 Da in molecular mass.
Connexins in the sinoatrial and atrioventricular nodes.
Dobrzynski et al., Manchester, United Kingdom. In Adv Cardiol, 2005
Consistent with this, in the center of the SAN there is no expression of Cx43 (the principal connexin of the working myocardium) and little expression of Cx40, but there is expression of Cx45 and Cx30.2, whereas in the periphery of the SAN Cx43 as well Cx45 is expressed.
Cardiac connexins: genes to nexus.
Spray et al., United States. In Adv Cardiol, 2005
Of the connexins, at least 5 (Cx30.2,
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