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Cullin 4A

Cul4A, cullin 4A
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, DDB1, Rbx1, CAN
Papers using Cul4A antibodies
Human immunodeficiency virus type 1 Vpr protein does not modulate surface expression of the CD4 receptor
Früh Klaus, In PLoS Pathogens, 2001
... The goat polyclonal antibody against CUL4A was obtained from Santa Cruz Biotechnology ( ...
Papers on Cul4A
CUL4A expression in pediatric osteosarcoma tissues and its effect on cell growth in osteosarcoma cells.
Fang et al., Beijing, China. In Tumour Biol, Jan 2016
Aberrant expression of the Cullin 4A (CUL4A) is found in many tumor types, but the role of CUL4A in OS progression remains largely unknown.
The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications.
Ren et al., Tianjin, China. In Oncotarget, Jan 2016
The CUL4 subfamily includes two members, CUL4A and CUL4B, which share extensively sequence identity and functional redundancy.
Cryptic 13q34 and 4q35.2 Deletions in an Italian Family.
Martorana et al., Parma, Italy. In Cytogenet Genome Res, Jan 2016
The deleted region on chromosome 13 involves several genes (ATP11A, MCF2L, F7, F10, PROZ, PCID2, CUL4A, and LAMP1); some of these seem to play a role in the proband's phenotype.
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B.
Zhou et al., United States. In Gene, Dec 2015
The cullin 4 subfamily of genes includes CUL4A and CUL4B, which share a mostly identical amino acid sequence aside from the elongated N-terminal region in CUL4B.
The role of cullin proteins in gastric cancer.
Yao et al., Hohhot, China. In Tumour Biol, Nov 2015
There are seven cullin proteins that have been identified in eukaryotes: CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, and CUL7/p53-associated parkin-like cytoplasmic protein.
Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells.
Tsai et al., San Francisco, United States. In Oncol Rep, Nov 2015
UNASSIGNED: Cullin 4A (Cul4A) promotes oncogenesis through overexpression and then ubiquitination‑mediated proteolysis of tumor suppressors in various types of cancers.
CUL4A facilitates hepatocarcinogenesis by promoting cell cycle progression and epithelial-mesenchymal transition.
Liang et al., Jinan, China. In Sci Rep, 2014
CUL4A, a member of the CULLIN family, functions as a scaffold protein for an E3 ubiquitin ligase.
Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma.
Huang et al., Kao-hsiung, Taiwan. In Plos One, 2014
We examined two iCCA cell lines and 86 cases of intrahepatic cholangiocarcinoma to analyze copy number of three target genes, including cullin 4A (CUL4A), insulin receptor substrate 2 (IRS2), and transcription factor Dp-1 (TFDP1) at 13q34 by quantitative real-time polymerase chain reaction.
Monitoring regulation of DNA repair activities of cultured cells in-gel using the comet assay.
Parsons et al., Liverpool, United Kingdom. In Front Genet, 2013
For example, we have shown that the E3 ubiquitin ligase Mule, the tumor suppressor protein ARF, and the deubiquitylation enzyme USP47 modulate DNA repair by controlling cellular levels of DNA polymerase β, and also that polynucleotide kinase phosphatase levels are controlled by ATM-dependant phosphorylation and Cul4A-DDB1-STRAP-dependent ubiquitylation.
CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases.
Nag et al., New Delhi, India. In Open Biol, 2013
The ability of cullin 4A (CUL4A), a scaffold protein, to recruit a repertoire of substrate adaptors allows it to assemble into distinct E3 ligase complexes to mediate turnover of key regulatory proteins.
A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.
Zhang et al., Rochester, United States. In Cell, 2013
Similar phenotypes occur in human cells in which the ortholog of Rtt101(Mms1), Cul4A(DDB1), is depleted.
Epidermal growth factor receptor protects proliferating cell nuclear antigen from cullin 4A protein-mediated proteolysis.
Wang et al., Cincinnati, United States. In J Biol Chem, 2012
Activation of EGFR inhibits the interaction of PCNA with CUL4A, whereas inhibition of EGFR leads to increased CUL4A-PCNA interaction and CUL4A-dependent ubiquitin-mediated degradation of PCNA
Overexpression of the human ubiquitin E3 ligase CUL4A alleviates hypoxia-reoxygenation injury in pheochromocytoma (PC12) cells.
Zhang et al., Changsha, China. In Biochem Biophys Res Commun, 2012
hCUL4A suppresses apoptosis and DNA damage by regulating apoptosis-related proteins and cell cycle regulators (Bcl-2, caspase-3, p53 and p27); consequently, hCUL4A promotes cell survival.
Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.
Legerski et al., Houston, United States. In Cell Cycle, 2012
Artemis and DDB2 regulate p27 via the Cul4A-based E3 ligase complex.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Thomä et al., Basel, Switzerland. In Cell, 2011
The structures of the fully assembled DDB1-DDB2-CUL4A/B-RBX1 (CRL4(DDB2)) ligases reveal that the mobility of the ligase arm creates a defined ubiquitination zone around the damage, which precludes direct ligase activation by DNA lesions.
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Thomä et al., Basel, Switzerland. In Febs Lett, 2011
Studies indicate the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 in DNA repair of UV-induced DNA lesions.
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis.
Ma et al., Saint Louis, United States. In Dev Biol, 2011
this study revealed an indispensable role for Cul4a during male germ cell meiosis.
Identification of a primary target of thalidomide teratogenicity.
Handa et al., Yokohama, Japan. In Science, 2010
CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks.
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Zhang et al., New Haven, United States. In Nat Cell Biol, 2006
We found that CUL4A-DDB1 interacts with H3 methylated mononucleosomes and peptides.
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Zheng et al., Seattle, United States. In Nature, 2006
crystallographic analyses of the virally hijacked form of the human DDB1-CUL4A-ROC1 machinery
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