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Troponin T type 2

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, cardiac troponin I, AGE
Papers using cTnT antibodies
Requirement of transcription factor NFAT in developing atrial myocardium
Chow Chi-Wing et al., In The Journal of Cell Biology, 2000
... Antibodies against NFATc2 (#sc-7295), NFATc4 (#sc-13036), desmin (#sc-7559), vinculin (#sc-7649), cTnI (#sc-8118), and cTnT (#sc-8121) were obtained from Santa Cruz Biotechnology, Inc ...
Papers on cTnT
Exosomes and nanotubes: Control of immune cell communication.
Cox et al., United States. In Int J Biochem Cell Biol, Feb 2016
Exosomes and tunneling nanotubes (TNTs) are two means of communication used by immune cells that contribute to immune functions.
Elevated Plasma Cardiac Troponin T Levels due to Skeletal Muscle Damage in Pompe Disease.
Pijnappel et al., Rotterdam, Netherlands. In Circ Cardiovasc Genet, Feb 2016
BACKGROUND: -Elevated plasma cardiac troponin T (cTnT) levels in patients with neuromuscular disorders may erroneously lead to the diagnosis of acute myocardial infarction (AMI) or myocardial injury.
Apelin: An Endogenous Peptide Essential for Cardiomyogenic Differentiation of Mesenchymal Stem Cells via Activating Extracellular Signal-Regulated Kinase 1/2 and 5.
Gao et al., Beijing, China. In Cell Biol Int, Feb 2016
The silencing expression of apelin in Wharton's jelly-derived mesenchymal stem cells decreased the expression of several critical cardiac progenitor transcription factors (Mesp1, Mef2c, NKX2.5) and cardiac phenotypes (cardiac α-actin, β-MHC, cTnT and connexin-43).
TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.
Jin et al., Detroit, United States. In Gene, Feb 2016
Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT.
Photoluminescence detection of 2,4,6-trinitrotoluene (TNT) binding on diatom frustule biosilica functionalized with an anti-TNT monoclonal antibody fragment.
Rorrer et al., Corvallis, United States. In Biosens Bioelectron, Feb 2016
UNASSIGNED: A selective and label-free biosensor for detection of the explosive compound 2,4,6-trinitrotoluene (TNT) in aqueous solution was developed based on the principle of photoluminescence quenching of upon immunocomplex formation with antibody-functionalized diatom frustule biosilica.
Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells.
Lim et al., Australia. In Stem Cells Int, Dec 2015
Acute electrical stimulation also significantly increased the cardiac gene expression of ACTC1, TNNT2, MYH7, and MYL7.
Harnessing microbial gene pools to remediate persistent organic pollutants using genetically modified plants-a viable technology?
Bruce et al., York, United Kingdom. In J Exp Bot, Nov 2015
Examples include plants developed to degrade 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), trichloroethylene (TCE), and polychlorinated biphenyls (PCBs).
Clinical implications of the intrinsic molecular subtypes of breast cancer.
Muñoz et al., Barcelona, Spain. In Breast, Nov 2015
Importantly, the distinction between Basal-like versus non-Basal-like within TNBC might predict survival following (neo)adjvuvant multi-agent chemotherapy, bevacizumab benefit in the neoadjuvant setting (CALGB40603), and docetaxel vs. carboplatin benefit in first-line metastatic disease (TNT study).
Prognostic Value of Biomarkers in Acute Non-massive Pulmonary Embolism: A Systematic Review and Meta-analysis.
Hosur et al., Scranton, United States. In Lung, Oct 2015
H-FABP has the lowest negative likelihood ratio (NLR) of 0.17 for mortality followed by high-sensitive cardiac troponin T (hs-cTnT) with NLR of 0.21.
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Wu et al., Stanford, United States. In Cell Stem Cell, Aug 2015
Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein.
Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?
Olivotto et al., Monastir, Tunisia. In Glob Cardiol Sci Pract, 2014
Using the Illumina platform, a panel of 12 genes was analyzed including myosin binding protein C (MYBPC3), beta-myosin heavy chain (MYH7), regulatory and essential light chains (MYL2 and MYL3), troponin-T (TNNT2), troponin-I (TNNI3), troponin-C (TNNC1), alpha-tropomyosin (TPM1), alpha-actin (ACTC1), alpha-actinin-2 (ACTN2) as well as alfa-galactosidase (GLA), 5'-AMP-activated protein (PKRAG2), transthyretin (TTR) and lysosomal-associated membrane protein-2 (LAMP2) for exclusion of phenocopies.
Chemically defined generation of human cardiomyocytes.
Wu et al., Stanford, United States. In Nat Methods, 2014
Along with small molecule-based induction of differentiation, this protocol produced contractile sheets of up to 95% TNNT2(+) cardiomyocytes at a yield of up to 100 cardiomyocytes for every input pluripotent cell and was effective in 11 hiPSC lines tested.
Synthetic ion transporters that work with anion-π interactions, halogen bonds, and anion-macrodipole interactions.
Matile et al., Genève, Switzerland. In Acc Chem Res, 2014
Anion-π interactions, the poorly explored counterpart of cation-π interactions, occur in aromatic systems with a positive quadrupole moment, such as TNT or hexafluorobenzene.
High-sensitivity cardiac troponin in the distinction of acute myocardial infarction from acute cardiac noncoronary artery disease.
Mueller et al., Basel, Switzerland. In Circulation, 2012
The combined use of high-sensitivity cardiac troponin T at presentation and its early absolute change discriminates between patients with myocardial infarction and those with cardiac noncoronary artery disease.
Cardiac microinjury measured by troponin T predicts collagen metabolism in adults aged >=65 years with heart failure.
Christenson et al., Baltimore, United States. In Circ Heart Fail, 2012
Increases in myocardial microinjury measured by changes in cTnT adversely affect markers of collagen metabolism in heart failure.
Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice.
Zhang et al., Beijing, China. In Hypertension, 2012
Data sugget that knockdown or downregulation of CYP2E1 might be a therapeutic strategy to control the development of dilated cardiomyopathy (DCM) after mutations of cTnT(R141W) or other factors.
The C-terminus of troponin T is essential for maintaining the inactive state of regulated actin.
Chalovich et al., Greenville, United States. In Biophys J, 2012
TnT has a previously unrecognized role in forming the inactive state of regulated actin.
Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes.
Sallan et al., Miami, United States. In J Clin Oncol, 2012
Echocardiograms and serial serum measurements of cardiac troponin T (cTnT; cardiac injury biomarker), N-terminal pro-brain natriuretic peptide (NT-proBNP; cardiomyopathy biomarker), and high-sensitivity C-reactive protein (hsCRP; inflammatory biomarker) were obtained before, during, and after treatment.
Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.
Davis et al., Columbus, United States. In Plos One, 2011
The disease-related protein modifications alter Ca(2+) binding by influencing both the association and dissociation rates of thin filament Ca(2+) exchange.
Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population.
McGuire et al., Dallas, United States. In Jama, 2011
CONTEXT: Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk of death and adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.
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