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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Tensin 4

Cten, TNS4, C-terminal tensin-like protein, C-terminal tensin-like, Tensin4
Top mentioned proteins: TNS, V1a, HAD, CAN, STAT3
Papers on Cten
ΔNp63α Transcriptionally Regulates the Expression of CTEN That Is Associated with Prostate Cell Adhesion.
Liao et al., Taipei, Taiwan. In Plos One, Dec 2015
In this study, we identify C-terminal tensin-like (CTEN) molecule as a downstream target of ΔNp63α, the predominant p63 isoform expressed in epithelium.
Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma.
Ng et al., Hong Kong, Hong Kong. In Oncotarget, Sep 2015
The focal adhesion protein Tensin4, also known as cten (c-terminal tensin like), is structurally distinct from the three other members in the Tensin family.
C-terminal tensin-like protein mediates invasion of human lung cancer cells and is regulated by signal transducer and activator of transcription 3.
Weyant et al., Aurora, United States. In J Thorac Cardiovasc Surg, 2015
OBJECTIVES: C-terminal tensin-like (Cten) protein, a component of focal adhesions, contributes to cell motility and invasion in multiple human cancers.
Proteomic analysis of susceptibility in intestinal stromal tumors.
Zhao et al., Beijing, China. In Genet Mol Res, 2014
Human SGC7901 gastric cells were selected and divided into a blank control group (untransfected SGC7901 cells), a negative control group [SGC7901 cells transfected with negative interference control-small interfering RNA (siRNA)], and a COOH-terminus tensin-like molecule (CTEN)-siRNA-1 group (SGC7901 cells transfected with CTEN-siRNA-1).
[Correlation between the expression of C-terminal tensin-like protein and the prognosis of hepatocellular carcinoma].
Zeng et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2014
OBJECTIVE: To explore the correlation between the expression of C-terminal tensin-like protein (CTEN) and the prognosis of hepatocellular carcinoma (HCC).
Long-term efficacy and safety of aerosolized tobramycin 300 mg/4 ml in cystic fibrosis.
Antipkin et al., Busko-Zdrój, Poland. In Pediatr Pulmonol, 2014
OBJECTIVES: The long-term safety and efficacy of intermittent (28-day "on"/"off" cycles) inhaled tobramycin nebulization solution 300 mg/4 ml (TNS4, Bramitob(®)/Bethkis(®)) was assessed over 56 weeks in CF patients aged ≥6 years having baseline 1 sec forced expiratory volume (FEV(1)) 40-80% predicted.
Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration.
Lo et al., Sacramento, United States. In Mol Carcinog, 2014
Cten is a focal adhesion molecule that is expressed at very low levels in most normal tissues.
Nuclear expression of phosphorylated focal adhesion kinase is associated with poor prognosis in human colorectal cancer.
Ilyas et al., Medina, Saudi Arabia. In Anticancer Res, 2014
AIM: To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression.
C-terminal tensin-like (CTEN): a promising biomarker and target for cancer.
Lo, Sacramento, United States. In Int J Biochem Cell Biol, 2014
C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family.
Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.
Ivaska et al., Turku, Finland. In Dev Cell, 2014
Independently, Tensin-4 (TNS4) is emerging as a putative oncogene in many cancer types, but the mechanisms of TNS4 oncogenic activity are not well established.
A mechanically-induced colon cancer cell population shows increased metastatic potential.
Kuhlenschmidt et al., Urbana, United States. In Mol Cancer, 2013
The expression of some genes, such as ALDH3A1, TNS4, CLDN2, and AKR1B10, which are known to play important roles in cancer cell migration, invasion, proliferation and apoptosis, were increased in HCT-8 R cells.
Indirubin derivative 6BIO suppresses metastasis.
Vollmar et al., München, Germany. In Cancer Res, 2013
Instead, the Jak/STAT3 signaling pathway appeared to play a major role through modulation of its downstream migration regulators C-terminal tensin-like protein and matrix metalloproteinase 2. However, PDK1 and GSK3β contributed to the overall response to 6BIO, as silencing of all three pathways resulted in almost complete inhibition of migration, phenocopying the 6BIO response.
CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.
Lo et al., Sacramento, United States. In Cancer Res, 2013
C-terminal tensin-like (CTEN; TNS4) is a focal adhesion molecule that is a member of the tensin family.
C-terminal tensin-like protein is a novel prognostic marker for primary melanoma patients.
Li et al., Vancouver, Canada. In Plos One, 2012
BACKGROUND: C-terminal tensin-like protein (Cten) is a focal adhesion protein originally identified as a tumor suppressor in prostate cancer.
From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities.
Poli et al., In Horm Mol Biol Clin Investig, 2012
These features were mediated by STAT3-dependent over-expression of the C-terminal tensin-like (Cten) focal adhesion protein.
Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer.
Ilyas et al., Nottingham, United Kingdom. In Oncogene, 2011
Cten expression is of prognostic significance in colorectal carcinoma, and delineate a Cten-ILK pathway controlling cell motility and possibly promoting metastasis.
CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis.
Green et al., Nottingham, United Kingdom. In Breast Cancer Res Treat, 2011
CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma.
Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas.
Ilyas et al., Nottingham, United Kingdom. In Plos One, 2010
conclude that, in the colon and pancreas, Cten is a downstream target of Kras and may be a mechanism through which Kras regulates of cell motility
CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer.
Namiki et al., Kanazawa, Japan. In Prostate, 2010
CTEN plays an important role in paclitaxel sensitivity, and CTEN expression level may be a prognostic predictive factor for prostate cancer patients.
Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin.
Lo et al., Sacramento, United States. In Cancer Res, 2009
Cten is a novel nuclear partner of beta-catenin, and has an oncogenic activity in colon cancers.
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