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Melanoma antigen family C, 2

CT10, MAGE-C2, HCA587
This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Crk, CT7, CAN, NY-ESO-1, Src
Papers on CT10
Pharmacokinetics and pharmacodynamics of dasatinib in the chronic phase of newly diagnosed chronic myeloid leukemia.
Inter-Michinoku Dasatinib Study Group (IMIDAS) et al., Morioka, Japan. In Eur J Clin Pharmacol, Feb 2016
METHODS: The dasatinib concentration required to inhibit 50 % of the CrkL (CT10 regulator of kinase like) phosphorylation in bone marrow CD34+ cells (half maximal (50 %) inhibitory concentration (IC50)CD34+cells) was calculated from each patient's dose-response curve using flow cytometry.
The expression of MAGE-C1 and MAGE-C2 in breast cancer and their clinical significance.
Shan et al., Shijiazhuang, China. In Am J Surg, Jan 2016
BACKGROUND: Our study aims to analyze the expression pattern, mechanism, and prognostic significance of melanoma-associated antigen MAGE-C1 and MAGE-C2 in breast cancer.
Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: sleep EEG correlates in rodents and healthy men.
Drinkenburg et al., Beerse, Belgium. In Neuropharmacology, Jan 2016
At CT5 similar effects were elicited, at CT10 only deep sleep was enhanced.
Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E.
Yin et al., Beijing, China. In Oncotarget, Jan 2016
Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors.
Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.
Fitsche et al., Zürich, Switzerland. In Biomed Res Int, 2014
As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expression throughout the different subtypes of mucosal melanoma and tumor development.
Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma.
Zhang et al., Zhengzhou, China. In Int J Clin Exp Pathol, 2014
We investigated the expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 to determine if combinatorial expressions of CTAs might be as potential prognostic markers for patients with hepatocellular carcinoma (HCC).
The role of CT10 regulation of kinase-like in cancer.
Sun et al., Dalian, China. In Future Oncol, 2014
V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) is a member of CRK family.
The adaptor protein Crk in immune response.
Liu, Houston, United States. In Immunol Cell Biol, 2014
The adaptor proteins Crk (CT10 (chicken tumor virus number 10) regulator of kinase), including CrkI, CrkII and Crk-like, are important signal molecules that regulate a variety of cellular processes.
GAB2--a scaffolding protein in cancer.
Celebi et al., New York City, United States. In Mol Cancer Res, 2012
Grb2-associated binding protein 2 (GAB2) scaffolding protein is an intermediary molecule that links plasma membrane receptor signaling including receptor tyrosine kinases with the downstream effectors, such as protein tyrosine phosphatase, nonreceptor type 11 (SHP2), p85 subunit of phosphoinositide-3 kinase (PI3-K), phospholipase C-gamma 1 (PLC-γ), v-crk sarcoma virus CT10 (CRK), Src homology 2 domain containing transforming protein 1 (SHC), and SH2 containing inositol phosphatase (SHIP).
The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress.
Oakes et al., San Francisco, United States. In Nat Cell Biol, 2012
We discovered that the principal component of the purified pro-apoptotic activity is the proto-oncoprotein CRK (CT10-regulated kinase), an adaptor protein with no known catalytic activity.
[Diagnosis of tumours of the liver and the biliary tract: new tissue and serum markers].
Riener, Erlangen, Germany. In Pathologe, 2011
Studies have shown that the oncofetal protein "IGF-II mRNA-binding protein 3" (IMP3), the cell adhesion molecules P-cadherin and CD24, the cancer testis antigen MAGE-C2/CT-10 as well as the protein periostin can be used as tissue markers in the diagnosis of HCC and CCC.
Identification of promiscuous HLA-DR-restricted CD4⁺ T-cell epitopes on the cancer-testis antigen HCA587.
Yin et al., Beijing, China. In Cancer Sci, 2011
p43-57 is the first HCA587-derived major histocompatibility complex class II-restricted epitope to fulfil all prerequisites for use as a peptide vaccine in patients with HCA587-expressing tumors
MAGEC2 is a sensitive and novel marker for seminoma: a tissue microarray analysis of 325 testicular germ cell tumors.
Moch et al., Zürich, Switzerland. In Mod Pathol, 2011
MAGEC2 is a sensitive and novel marker for seminoma.
Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients.
Moch et al., Zürich, Switzerland. In Plos One, 2010
Results suggest that the expression of MAGE-C1/CT7 and MAGE-C2/CT10 in primary melanoma is a potent predictor of sentinel lymph node metastasis.
MAGE-C2/CT10 protein expression is an independent predictor of recurrence in prostate cancer.
Wild et al., Zürich, Switzerland. In Plos One, 2010
MAGE-C2/CT10 expression in prostate cancer correlates with the degree of malignancy and indicates a higher risk for biochemical recurrence after radical prostatectomy.
MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression.
Longley et al., Madison, United States. In Plos One, 2010
Expression of MAGE I proteins, MAGE-A3 or MAGE-C2, relieved repression of a reporter gene by ZNF382 and MAGE I expression relieved KAP1 mediated ID1 repression.
Prognostic factors in chronic myeloid leukaemia.
Cervantes et al., Valencia, Spain. In Best Pract Res Clin Haematol, 2009
Biological markers such as gene expression profile, v-crk sarcoma virus CT10 oncogene homologue (avian)-like (Crkl) phosphorylation or expression of imatinib transporter proteins have been shown to be useful to predict the response to imatinib.
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins.
Hanafusa et al., New York City, United States. In Science, 1990
Although the oncogene product of CT10 virus, P47gag-crk, does not itself phosphorylate proteins at tyrosine residues, it elevates phosphotyrosine in transformed cells.
A novel viral oncogene with structural similarity to phospholipase C.
Hanafusa et al., New York City, United States. In Nature, 1988
We have cloned the previously uncharacterized avian sarcoma virus CT10 and sequenced its genome.
Sequence similarity of phospholipase C with the non-catalytic region of src.
Knopf et al., Cambridge, United States. In Nature, 1988
The newly characterized crk transforming gene of the avian sarcoma virus CT10 also contains extensive sequence similarities with PLC-148.
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