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Regulator of calcineurin 2

Csp2, ZAKI-4, Rcn2, MCIP2, DSCR1L1, RCAN2
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Csp3, CAN, ACID, DSCR1, V1a
Papers on Csp2
An Analog-Sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway.
Martín et al., Madrid, Spain. In J Biol Chem, Feb 2016
Moreover, we identified the calcineurin regulator Rcn2, the 4E-BP translation repressor protein Caf20, and the Golgi-associated adaptor Gga1 as novel targets for Slt2.
Sequence variation of Bemisia tabaci Chemosensory Protein 2 in cryptic species B and Q: New DNA markers for whitefly recognition.
Picimbon et al., Jinan, China. In Gene, Feb 2016
The performances of CSP2-based CAPS for whitefly recognition were assessed using B. tabaci field collections from Shandong Province (P.R. China).
Chemosensory proteins of the eastern honeybee, Apis cerana: Identification, tissue distribution and olfactory related functional characterization.
Hu et al., Hangzhou, China. In Comp Biochem Physiol B Biochem Mol Biol, Feb 2016
On the contrary, AcerCSP2 showed a higher expression level in the forager antennae and legs than CSP2 of A. mellifera.
Antimicrobial and Anti-Biofilm Activity of Thiourea Derivatives Bearing 3-Amino-1H-1, 2, 4-Triazole Scaffold.
Struga et al., Warsaw, Poland. In Med Chem, Jan 2016
The aliphatic isothiocyanate was used as reagent leading to substitution on NH atom of 3-aminotriazole ring, whereas the triazole amino group was substituted when isothiocyanate group was bonded to the Csp2 hybridized atom, e.g. an aryl or C=O fragment.
Lithium Aluminate Complexes and Alumoles from 1,4-Dilithio-1,3-Butadienes and AlEt2Cl.
Xi et al., Beijing, China. In Inorg Chem, Dec 2015
The structure of the lithium aluminate complex 2-TMEDA showed that the Al atom adopted a tetra-coordinated mode bonded with two butadienyl Csp2 atoms and two ethyl Csp3 atoms.
Oxidant-Free Au(I)-Catalyzed Halide Exchange and C(sp2)-O Bond Forming Reactions.
Ribas et al., Girona, Spain. In J Am Chem Soc, Nov 2015
This study demonstrates unusual external oxidant-free Au(I)-catalyzed halide exchange (including fluorination) and Csp2-O bond formation reactions utilizing a model aryl halide macrocyclic substrate.
The N-acetylglucosamine catabolic gene cluster in Trichoderma reesei is controlled by the Ndt80-like transcription factor RON1.
Seidl-Seiboth et al., Vienna, Austria. In Mol Microbiol, Nov 2015
All GlcNAc cluster genes, as well as the GlcNAc transporter gene ngt1, and an additional transcriptional regulator gene, csp2, encoding the homolog of Neurospora crassa CSP2/GRHL, were functionally characterized by gene expression analysis and phenotypic characterization of knockout strains in T. reesei.
Silicates as Latent Alkyl Radical Precursors: Visible-Light Photocatalytic Oxidation of Hypervalent Bis-Catecholato Silicon Compounds.
Fensterbank et al., Paris, France. In Angew Chem Int Ed Engl, Oct 2015
This oxidative photocatalyzed process can be efficiently merged with nickel-catalyzed Csp2-Csp3 cross-coupling reactions.
Preparation and evaluation of monodispersed, submicron, non-porous silica particles functionalized with β-CD derivatives for chiral-pressurized capillary electrochromatography.
Chao et al., Shanghai, China. In Electrophoresis, Sep 2015
The submicron, non-porous, cyclodextrin-based chiral stationary phases (sub_μm-CSP2) exhibited excellent chiral recognition of a wide range of analytes including clenbuterol hydrochloride, mexiletine hydrochloride, chlorpheniramine maleate, esmolol hydrochloride, and metoprolol tartrate.
Cyclodextrin clicked chiral stationary phases with functionalities-tuned enantioseparations in high performance liquid chromatography.
Tang et al., Nanjing, China. In J Chromatogr A, Sep 2015
In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-β-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-β-CD (CSP2) onto alkynylated silica support.
Dual Role of the 1,2,3-Triazolium Ring as a Hydrogen-Bond Donor and Anion-π Receptor in Anion-Recognition Processes.
Molina et al., Murcia, Spain. In Chemistry, Jul 2015
On the other hand, receptor 10(2+)⋅2 BF4(-) (4-CH3O-C6H4) only displays combined Csp2-H/anion-π interactions between the two arms of the receptors and the bound anion rather than triazolium (CH)(+)⋅⋅⋅anion hydrogen bonding.
Modular Approach to Reductive C(sp2)-H and C(sp3)-H Silylation of Carboxylic Acid Derivatives through Single-Pot, Sequential Transition Metal Catalysis.
Jeon et al., Arlington, United States. In J Org Chem, Jun 2015
We report a modular approach to catalytic reductive Csp2-H and Csp3-H silylation of carboxylic acid derivatives encompassing esters, ketones, and aldehydes.
The first lutetacyclopentadienes: synthesis, structure, and diversified insertion/C-H activation reactivity.
Xi et al., Beijing, China. In Chemistry, May 2015
Both monoinsertion and double-insertion of two Lu-Csp2 bonds are observed.
Mice lacking the calcineurin inhibitor Rcan2 have an isolated defect of osteoblast function.
Williams et al., London, United Kingdom. In Endocrinology, 2012
Rcan2 regulates osteoblast function and its expression in bone is regulated by thyroid status in vivo
Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.
Shi et al., Charlottesville, United States. In Am J Physiol Heart Circ Physiol, 2011
Ath29 is confirmed to be a major atherosclerosis susceptibility locus affecting both early and advanced lesion formation in mice, and Rcn2 is identified as a novel regulator of cytokine expression.
Inactivation of the Rcan2 gene in mice ameliorates the age- and diet-induced obesity by causing a reduction in food intake.
Murata et al., Nagoya, Japan. In Plos One, 2010
an Rcan2-dependent mechanism which regulates food intake and promotes weight gain through a leptin-independent pathway
Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathway.
Jabbour et al., Edinburgh, United Kingdom. In Biochim Biophys Acta, 2009
our data have elucidated the molecular and cellular mechanism whereby PGF(2alpha) regulates CXCL8 expression via the FP receptor in endometrial adenocarcinomas and have highlighted RCAN1-4 as a negative regulator of CXCL8 expression
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.
Sadoshima et al., Newark, United States. In Am J Physiol Heart Circ Physiol, 2009
Genetic inhibition of calcineurin in Zaki-4 transgenic mice induces diastolic dysfunction in mice with chronic pressure overload.
The rapidly expanding CREC protein family: members, localization, function, and role in disease.
Honoré, Århus, Denmark. In Bioessays, 2009
The CREC family of low affinity, Ca2+-binding, multiple EF-hand proteins are encoded by five genes, RCN1, RCN2, RCN3, SDF4, and CALU, resulting in reticulocalbin, ER Ca2+-binding protein of 55 kDa (ERC-55), reticulocalbin-3, Ca2+-binding protein of 45 kDa (Cab45), and calumenin.
Topological analyses and bond characterization of 1,3,5,7-tetra-tert-butyl-s-indacene: a weak Csp3-H...H-Csp2-type dihydrogen interaction.
Wang et al., Taipei, Taiwan. In Acta Crystallogr A, 2004
Topological analyses of experimental and theoretical calculated electron densities of 1,3,5,7-tetra-tert-butyl-s-indacene provide bond characterizations of the chemical bond and of the pi-delocalization.
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