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Casein kinase 2, alpha prime polypeptide

CSNK2A2, CK2a2
Top mentioned proteins: SET, ACID, PICK1, CCTG, TIMP-3
Papers on CSNK2A2
Differential proteome association study of freeze-thaw damage in ram sperm.
Hu et al., Lanzhou, China. In Cryobiology, Dec 2015
Casein kinase II subunit alpha (CSNK2A2), a serine/threonine-selective protein kinase, is associated with sperm apoptosis.
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.
Trembley et al., Minneapolis, United States. In Breast Cancer Res, 2014
RNA expression levels of CDC2L1, CDC2L2, CCNL1, CCNL2, CSNK2A1, CSNK2A2, and CSNK2B genes in breast cancer subtypes were analyzed.
Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort.
Sanghera et al., In Circ Cardiovasc Genet, 2014
On combined discovery and stage 1 meta-analysis (n= 4013), we identified a novel relative telomere length locus at chromosome 16q21 represented by an intronic variant (rs74019828) in the CSNK2A2 gene (β=-0.38;
Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis.
Wells et al., London, United Kingdom. In Plos Curr, 2013
We measured expression of 11 candidate normalization genes (Cdc40, Htatsf1, Ap3d1, Csnk2a2, Fbxw2, Fbxo38, Pak1ip1, Zfp91, GAPDH, ActB, 18S) in three cell culture models of myogenesis (C2C12 , H2K2B4, and the dystrophic line H2KSF1).
Heart structure-specific transcriptomic atlas reveals conserved microRNA-mRNA interactions.
Couttet et al., Basel, Switzerland. In Plos One, 2012
Interactions between miR-1/Timp3, miR-125b/Rbm24, miR-204/Tgfbr2 and miR-208b/Csnk2a2 were identified and experimentally investigated in human pulmonary smooth muscle cells and luciferase reporter assays.
Kinase inhibition by the Jamaican ball moss, Tillandsia recurvata L.
Bryant et al., Kingston, Jamaica. In Anticancer Res, 2012
Out of the 40 kinases, the Jamaican ball moss selectively inhibited 5 (CSNK2A2, MEK5, GAK, FLT and DRAK1) and obtained Kd(50)s were below 20 μg/ml.
Enzymatic activity with an incomplete catalytic spine: insights from a comparative structural analysis of human CK2α and its paralogous isoform CK2α'.
Niefind et al., Köln, Germany. In Mol Cell Biochem, 2011
In hsCK2alpha' an open conformation of the interdomain hinge/helix alphaD region that is critical for ATP-binding is found corresponding to an incomplete catalytic spine. In contrast hsCK2alpha often adopts the canonical, PKA-like version of the catalytic spine.
Lack of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is accompanied by increased CK2α' levels.
Issinger et al., Odense, Denmark. In Mol Cell Biochem, 2011
Lack of DNA-PKcs is accompanied by an increase in the protein level of one of the catalytic isozymes of protein kinase CK2, i.e., CK2alpha' and a concomitant increase in CK2 activity.
[Molecular genetics of globozoospermia: an update].
Xia et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2011
Studies show that the pathogenic genes associated with globozoospermia include SPATA16, PICK1, GOPC, Hrb, Csnk2a2 and bs.
Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation.
Seger et al., Israel. In Mol Cell Biol, 2011
Results provide an important role of CK2 in regulating nuclear ERK activities.
Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface.
Niefind et al., Köln, Germany. In Biochemistry, 2011
A thorough investigation of CK2alpha identifies key energetic hot spots on the surface of CK2alpha and their thermostability and catalytic activity in comparison to the wild type subunit.
Structural basis of CX-4945 binding to human protein kinase CK2.
Le et al., United States. In Febs Lett, 2011
Data presented the crystal structures of CK2alpha in complex with CX-4945 and adenylyl phosphoramidate at 2.7 and 1.3 A, respectively.
A newly discovered mutation in PICK1 in a human with globozoospermia.
Lu et al., Changsha, China. In Asian J Androl, 2010
Disruption of several mouse genes, including Gopc (Golgi-associated PDZ and coiled-coil motif containing protein), Hrb (HIV-1 Rev binding protein), Csnk2a2 (casein kinase 2, alpha prime polypeptide) and Pick1 (protein interacting with C kinase 1), results in a phenotype similar to globozoospermia in humans, which suggests their potential role in the disease.
Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer.
Chance et al., Cleveland, United States. In Mol Cell Proteomics, 2009
A number of the proteins in these smaller subnetworks have been associated with the progression (CSNK2A2, PLK1, and IGFBP3) or metastatic potential (PDGFRB) of CRC.
Gene expression patterns in deceased donor kidneys developing delayed graft function after kidney transplantation.
Maluf et al., Richmond, United States. In Transplantation, 2008
Gene ontology terms classified the overexpressed genes in DDK with DGF as principally related to cell cycle/growth (e.g., IGFBP5, CSNK2A2), signal transduction (e.g., RASGRP3), immune response (e.g., CD83, BCL3, MX1), and metabolism (e.g., ENPP4, GBA3).
Genome-wide association of sleep and circadian phenotypes.
Wilk et al., Framingham, United States. In Bmc Med Genet, 2006
These peaks include several candidate sleep-related genes, including CSNK2A2, encoding a known component of the circadian molecular clock, and PROK2, encoding a putative transmitter of the behavioral circadian rhythm from the suprachiasmatic nucleus.
The catalytic subunit alpha' gene of human protein kinase CK2 (CSNK2A2): genomic organization, promoter identification and determination of Ets1 as a key regulator.
Pyerin et al., Heidelberg, Germany. In Mol Cell Biochem, 2005
Ets motifs play, in cooperation with Sp motif clusters, a central role in regulating CK2alpha' gene transcription.
Search for mutations involved in human globozoospermia.
Viville et al., Strasbourg, France. In Hum Reprod, 2005
Recently, a mouse lacking the casein kinase IIalpha' (encoded by the Csnk2a2 gene) was described.
Spermatogenesis of mice lacking CK2alpha': failure of germ cell survival and characteristic modifications of the spermatid nucleus.
Xu et al., Paris, France. In Mol Reprod Dev, 2003
Csnk2a2 encodes the CK2alpha'catalytic subunit of CK2 that is predominantly expressed in testis.
Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit.
Seldin et al., Boston, United States. In Nat Genet, 1999
The Ck2alpha and Ck2alpha' isoforms (products of the genes Csnk2a1 and Csnk2a2, respectively) are highly homologous, but the reason for their redundancy and evolutionary conservation is unknown.
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