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COP9 constitutive photomorphogenic homolog subunit 6

CSN6, hVIP, COPS6, Vpr-interacting protein, Sgn6
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Jab1, MPN, CAN, Cullin
Papers on CSN6
CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.
Sharon et al., Israel. In Cell Rep, Nov 2015
We show that CSNAP binds CSN3, CSN5, and CSN6, and its incorporation into the CSN complex is mediated through the C-terminal region involving conserved aromatic residues.
CSN6 positively regulates c-Jun in a MEKK1-dependent manner.
Lee et al., Houston, United States. In Cell Cycle, Nov 2015
The COP9 signalosome subunit 6 (CSN6) plays a critical role in ubiquitin-mediated protein degradation.
COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.
Lee et al., Shanghai, China. In Oncotarget, Oct 2015
The COP9 signalosome subunit 6 (CSN6) is involved in ubiquitin-mediated protein degradation.
ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.
Lee et al., Guangzhou, China. In Cancer Cell, Sep 2015
We found that CSN6, a subunit of COP9 signalosome, is overexpressed in CRC samples and that CSN6 overexpression is correlated with poor patient survival.
CSN6 deregulation impairs genome integrity in a COP1-dependent pathway.
Lee et al., Houston, United States. In Oncotarget, Jun 2015
Constitutive photomorphogenic 1 (COP1), an E3 ubiquitin ligase regulated by CSN6, is downregulated by DNA damage, but the biological consequences of this phenomenon are poorly understood.
Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.
Lee et al., Houston, United States. In Cell Cycle, 2014
The COP9 signalosome subunit 6 (CSN6), which is involved in ubiquitin-mediated protein degradation, is overexpressed in many types of cancer.
COP9 signalosome subunit 6 binds and inhibits avian leukosis virus integrase.
Tang et al., Beijing, China. In Biochem Biophys Res Commun, 2014
In this study, we identified the COP9 signalosome subunit 6 (CSN6) as a novel avian leukosis virus (ALV) integrase binding protein.
Crystal structure of the human CSN6 MPN domain.
Jiang et al., Beijing, China. In Biochem Biophys Res Commun, 2014
CSN5 and CSN6 are the only two MPN (Mpr1-Pad1-N-terminal) domain-containing subunits in the complex.
Crystal structure of the human COP9 signalosome.
Thomä et al., Basel, Switzerland. In Nature, 2014
CSN5 and its dimerization partner, CSN6, are intricately embedded at the core of the helical bundle.
Electron microscopy and in vitro deneddylation reveal similar architectures and biochemistry of isolated human and Flag-mouse COP9 signalosome complexes.
Dubiel et al., Martinsried, Germany. In Biochem Biophys Res Commun, 2014
CSN5 and CSN6 point away from the horseshoe.
Plant COP9 signalosome subunit 5, CSN5.
Wei et al., Chongqing, China. In Plant Sci, 2014
We also briefly discuss CSN6 genes, which are closely related share many similarities to CSN5.
Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer.
Echalier et al., Montpellier, France. In Plos One, 2013
The association of CSN5 and CSN6 MPN (for Mpr1/Pad1 N-terminal) domains activates its isopeptidase activity.
Structure and function of MPN (Mpr1/Pad1 N-terminal) domain-containing proteins.
Echalier et al., Montpellier, France. In Curr Protein Pept Sci, 2013
In eukaryotes, MPN domain-containing proteins are commonly found in association with other molecules in large protein complexes, where examples comprise; the 26S proteasome and the COP9 (Constitutive photomorphogenesis 9) signalosome complexes, including the MPN subunits, POH1 and Mov34, CSN5 and CSN6, respectively.
CSN6 drives carcinogenesis by positively regulating Myc stability.
Lee et al., Houston, United States. In Nat Commun, 2013
Here we show that Myc is a target of the CSN subunit 6 (CSN6)-Cullin signalling axis and that CSN6 is a positive regulator of Myc.
Roles of COP9 signalosome in cancer.
Yeung et al., Houston, United States. In Cell Cycle, 2011
Among the CSN subunits, CSN5 and CSN6 are the only two that each contain an MPN (Mpr1p and Pad1p N-terminal) domain.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
COPS6 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Lee et al., Houston, United States. In J Clin Invest, 2011
loss of CSN6 enhances p53-mediated tumor suppression in vivo and CSN6 plays an important role in regulating DNA damage-associated apoptosis and tumorigenesis through control of the MDM2-p53 signaling pathway
The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.
Dubiel et al., Berlin, Germany. In Apoptosis, 2008
For the first time our data demonstrate that CSN-mediated deneddylation can be regulated by active Casp3 and that the CSN executes a specific function during the apoptotic process.
The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.
Ulevitch et al., Los Angeles, United States. In J Biol Chem, 2007
critical role of caspase 8 in the processing of CSN6.
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