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G protein pathway suppressor 1

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, CAN, Jab1, V1a
Papers on CSN1
COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity.
Wang et al., New Haven, United States. In Circ Res, Dec 2015
The cullin deneddylation activity of the COP9 signalosome (CSN) requires all 8 CSN subunits (CSN1 through CSN8) and regulates cullin-RING ligases, thereby controlling ubiquitination of a large number of proteins; however, neither CSN nor cullin-RING ligases is known to regulate the degradation of cytosolic misfolded proteins.
Translation of Exercise Test Response to Training Intensity Using the Count Scale.
Xu et al., Beijing, China. In Respir Care, Oct 2015
During the first session, in which exercise was guided by the heart rate, the CSN and heart rate were obtained (ie, CSN1 and HR1) while the heart rate was increased by 20% compared with the resting heart rate.
Glasgow Prognostic Score Predicts Clinical Outcomes in Patients with Pancreatic Cancer Undergoing Adjuvant Gemcitabine Monotherapy After Curative Surgery.
Morimoto et al., Yokohama, Japan. In Anticancer Res, Sep 2015
RESULTS: The disease-free survival (DFS) and overall survival (OS) in patients with an elevated GPS (GPS1 or GPS2) were significantly poorer (p=0.001 and p=0.035, respectively, by log-rank test) than patients with a GPS of 0. An elevated GPS was found to be independently associated with poor DFS (p=0.002, by Cox regression model).
Glasgow Prognostic Score as a Prognostic Clinical Marker in T4 Esophageal Squamous Cell Carcinoma.
Hirakawa et al., Ōsaka, Japan. In Anticancer Res, Sep 2015
Patients were classified as GPS0, GPS1, or GPS2 based on C-reactive protein (CRP) ≤ 10 mg/l and albumin ≥ 35 g/l, CRP >10 mg/l or albumin <35 g/l, or CRP >10 mg/l and albumin <35 g/l, respectively.
Integration of the catalytic subunit activates deneddylase activity in vivo as final step in fungal COP9 signalosome assembly.
Braus et al., Göttingen, Germany. In Mol Microbiol, Jul 2015
The CSN1/CsnA N-terminus is dispensable for deneddylase activity but required for asexual spore formation.
Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach.
Ahmad et al., Madison, United States. In Oncotarget, May 2015
Four of these proteins (IL33, CUL5, GPS1 and DUSP4) appear to occupy regulatory nodes in key pathways.
Crystal structure of the human CSN6 MPN domain.
Jiang et al., Beijing, China. In Biochem Biophys Res Commun, 2014
The mammalian COP9 signalosome is an eight-subunit (CSN1-CSN8) complex that plays essential roles in multiple cellular and physiological processes.
The combination of platelet count and neutrophil lymphocyte ratio is a predictive factor in patients with esophageal squamous cell carcinoma.
Chen et al., Hangzhou, China. In Transl Oncol, 2014
Patients with one or no abnormal value were assigned to GPS1 or GPS0, respectively.
Dynamic regulation of the COP9 signalosome in response to DNA damage.
Sharon et al., Israel. In Mol Cell Biol, 2014
However, upon UV damage, a dose-dependent temporal shuttling of the CSN complex into the nucleus was seen, accompanied by upregulation of specific phosphorylations within CSN1, CSN3, and CSN8.
Prognostic significance of Glasgow prognostic score in patients undergoing esophagectomy for esophageal squamous cell carcinoma.
Chen et al., Hangzhou, China. In Saudi J Gastroenterol, 2014
Patients with one or no abnormal value were assigned to GPS1 or GPS0, respectively.
Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers.
Dubiel et al., Berlin, Germany. In Int J Biochem Cell Biol, 2013
The CSN-CRL pathway consists of the CSN possessing eight subunits (CSN1-CSN8) and one CRL consisting of a cullin, a RING-domain protein and a substrate recognition subunit (SRS).
The COP9 signalosome subunit 6 (CSN6): a potential oncogene.
Zheng et al., Xuzhou, China. In Cell Div, 2012
In mammalian cells, it consists of eight subunits (CSN1-CSN8).
Altered expression of COP9 signalosome proteins in preeclampsia.
Cimsir et al., Tokat, Turkey. In Gynecol Endocrinol, 2012
An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.
TSA1 interacts with CSN1/CSN and may be functionally involved in Arabidopsis seedling development in darkness.
Wang et al., Shanghai, China. In J Genet Genomics, 2011
TSA1 interacts with CSN1 and is involved in Arabidopsis seedling development in darkness.
Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets.
Hallstrom et al., Minneapolis, United States. In Cell Cycle, 2011
Jab1/CSN5, when elevated in certain tumors, may evade triggering E2F1 aopotosis through the frequent, simultaneous co-activation of PI3K activity.
Roles of COP9 signalosome in cancer.
Yeung et al., Houston, United States. In Cell Cycle, 2011
In mammalian cells, it consists of eight subunits (CSN1 to CSN8).
CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.
Wei et al., New Haven, United States. In Protein Cell, 2011
CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase.
Wang et al., Taipei, Taiwan. In Plant Physiol, 2011
A novel prenyltransferases from Arabidopsis thaliana is identified as a trans-type polyprenyl pyrophosphate synthase which is involved in the synthesis of multiple medium/long-chain products. [AtPPPS]
The COP9 signalosome: mediating between kinase signaling and protein degradation.
Chamovitz et al., Tel Aviv-Yafo, Israel. In Curr Protein Pept Sci, 2004
It contains eight core subunits, named CSN1-8, in order of decreasing molecular weight.
Structure of the Sec7 domain of the Arf exchange factor ARNO.
Chardin et al., Gif-sur-Yvette, France. In Nature, 1998
An exchange factor for human Arf1, ARNO, and two closely related proteins, named cytohesin 1 and GPS1, have been identified.
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