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Chondroitin sulfate N-acetylgalactosaminyltransferase 1

CSGalNAcT-1, beta4GalNAcT, Chondroitin sulfate N-acetylgalactosaminyltransferase-1, chondroitin sulfate N-acetylgalactosaminyltransferase, beta4GalNAc-T1, chondroitin beta 1,4 N-acetylgalactosaminyltransferase
Top mentioned proteins: ACID, glycosyltransferase, POLYMERASE, HAD, syndecan-1
Papers on CSGalNAcT-1
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
Farrer et al., Boston, United States. In Biol Psychiatry, Apr 2015
Two chromosome 8 regions were associated: p = 4.45 × 10(-8) at DLC1 SNP rs289519 (unadjusted) and p = 1.10 × 10(-9) at rs6996964 (adjusted for other substances), located between CSGALNACT1 and INTS10.
Chondroitin sulfate N-acetylgalactosaminyltransferase-2 contributes to the replication of infectious bursal disease virus via interaction with the capsid protein VP2.
Wang et al., Harbin, China. In Viruses, Mar 2015
We found that chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2), a typical type II transmembrane protein located in Golgi apparatus, could interact with VP2, and we confirmed this interaction by co-immunoprecipitation and confocal laser scanning microscopy assays.
Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth.
Shriver et al., United States. In Exp Cell Res, Feb 2015
Importantly, enzymes generating chondroitin sulfate glycosaminoglycans (CS) such as CHST11, CHST15, and CSGALNACT1 were upregulated in HCC38(NEDD9) compared to HCC38(Vector).
Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid.
Al-Maghrabi et al., In Bmc Genomics, 2014
The most significantly downregulated genes in FVPTCs included interaction protein for cytohesin exchange factors 1 (IPCEF1), G protein-coupled receptor 155 (GPR155), Purkinje cell protein 4 (PCP4), chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1), and glutamate receptor interacting protein 1 (GRIP1).
Alterations in the chondroitin sulfate chain in human osteoarthritic cartilage of the knee.
Matsumoto et al., Gifu, Japan. In Osteoarthritis Cartilage, 2014
Three genes encoding CS glycosyltransferases (CHPF, CSGALNACT1, CSGALNACT2) were expressed at lower levels in lesion cartilage.
Effect of Arctium lappa (burdock) extract on canine dermal fibroblasts.
Colitti et al., Udine, Italy. In Vet Immunol Immunopathol, 2014
The expression profile of canine dermal fibroblasts treated with burdock extract with or without H2O2 stimulation, showed an up-regulation of mitochondrial superoxide dismutase (SOD2), disheveled 3 (DVL3) and chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2).
Genetic alterations of chromosome 8 genes in oral cancer.
Zain et al., Kuala Lumpur, Malaysia. In Sci Rep, 2013
MSRA (21.2) and CSGALNACT1 (12.1%).
Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis.
Guo et al., Xi'an, China. In Int Orthop, 2013
The mRNA and protein expressions of CSGalNAcT-1 and Hapln-1 in chondrocytes were verified by reverse transcription polymerase chain reaction (RT-PCR) and western blot, and their expression in cartilage were verified with immunocytochemical analysis.
A genome-wide association study of a sustained pattern of antidepressant response.
Hamilton et al., Los Angeles, United States. In J Psychiatr Res, 2013
Joint analysis of these 18 SNPs resulted in the strongest signal coming from rs7816924 (p=2.11×10(-7)), which resides in chondroitin sulfate N-acetylgalactosaminyltransferase 1 gene (CSGALNACT1).
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.
Fournel-Gigleux et al., Vandœuvre-lès-Nancy, France. In Glycobiology, 2012
CSGalNAcT-1 exhibited higher enzymatic efficiency toward monosulfated trisaccharides substituted at C4 or C6 position of Gal1, and at C6 of Gal2 compared with the unsulfated oligosaccharide.
The reconstruction of transcriptional networks reveals critical genes with implications for clinical outcome of multiple myeloma.
Neri et al., Milano, Italy. In Clin Cancer Res, 2012
Specifically, a critical-gene model, comprising FAM53B, KIF21B, WHSC1, and TMPO, and a neighbor-gene model, comprising BLNK shared neighbors CSGALNACT1 and SLC7A7, predicted survival in all data sets with follow-up information.
Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.
Cogné et al., Limoges, France. In Eur J Immunol, 2011
By looking at the glycosylation-related gene expression patterns among B-cell populations, we determined in this study that the strongest variations were observed for CSGalNAcT-1 and EXTL1.
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.
Narimatsu et al., Tsukuba, Japan. In J Biol Chem, 2011
Here, we generated and analyzed mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGalNAcT-1).
Chondroitin beta-1,4-N-acetylgalactosaminyltransferase-1 missense mutations are associated with neuropathies.
Kusunoki et al., Ōsaka, Japan. In J Hum Genet, 2011
CSGALNACT1 missense mutations are associated with neuropathies.
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.
Igarashi et al., Niigata, Japan. In Biochem J, 2010
To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice.
Comparison between human fetal and adult skin.
Ulrich et al., Beverwijk, Netherlands. In Arch Dermatol Res, 2010
higher expression in the fetal skin than in adult skin
Expression of genes encoding for proteins involved in heparan sulphate and chondroitin sulphate chain synthesis and modification in normal and malignant plasma cells.
Klein et al., Montpellier, France. In Br J Haematol, 2009
Sixteen genes were significantly different between normal and malignant plasma cells, nine of these genes -EXT2, CHSY3, CSGALNACT1, HS3ST2, HS2ST1, CHST11, CSGALNACT2, HPSE, SULF2 - encode proteins involved in glycosaminoglycan chain synthesis or modifications.
Differential roles of two N-acetylgalactosaminyltransferases, CSGalNAcT-1, and a novel enzyme, CSGalNAcT-2. Initiation and elongation in synthesis of chondroitin sulfate.
Narimatsu et al., Tsukuba, Japan. In J Biol Chem, 2003
plays a role in the initiation and elongation in the synthesis of chondroitin sulfate
Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis.
Narimatsu et al., Tsukuba, Japan. In J Biol Chem, 2002
These results suggest that this enzyme has N-acetylgalactosaminyltransferase activity in both the elongation and initiation of chondroitin sulfate synthesis.
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