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Chorionic somatomammotropin hormone 1

CsA, Placental Lactogen
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, iMpact
Papers using CsA antibodies
Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)
Tjwa Marc, In PLoS ONE, 2009
... (LEHD, 1 h, 20 µM), IETD-cho (IETD, 1 h, 20 µM) from Alexis Biochemicals (Lausen, Switzerland), cyclosporine A (CsA, 15 min, 1 µM), calpeptin (1 h, 250 µM), bapta-AM (1h, 10 µM) from Biomol (Plymouth Meeting, PA, USA), ...
Regulation of myocardial substrate metabolism during increased energy expenditure: insights from computational studies
Kögler Harald et al., In Basic Research in Cardiology, 2005
... After incubation with CsA, rabbit papillary muscles were lysed in 50 µl calcineurin assay buffer (BioMol, Plymouth Meeting, PA) ...
Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines.
Mueller Ulrich, In PLoS ONE, 2001
There were four control groups: G93A Media-injected (n = 10), G93A Cyclosporine A (CsA)-injected (n = 10), C57BL/6 (n = 9) and transgenic mice (BL6/SJL) carrying the ...
Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K+-ATPase through proteasomal and endo−/lysosomal proteolytic pathways.
Maki Carl G., In PLoS ONE, 1998
... CsA, SP600125, 4-PBA, and 3-(4,5-dimethyl-2-thiazolyl)-2,5-dimethyl-2H-tetrazolium bromide (MTT) were purchased from Merck (Darmstadt, Germany) ...
Papers on CsA
Everolimus immunosuppression in kidney transplantation: What is the optimal strategy?
Arns et al., Essen, Germany. In Transplant Rev (orlando), Jan 2016
One study which used very low CsA exposure in everolimus-treated patients reported a substantial improvement in estimated GFR compared to controls, but this requires confirmation.
Enteric-coated mycophenolate sodium could be an alternative to methotrexate for GVHD prophylaxis.
Lazarevic, Lund, Sweden. In Eur J Haematol, Jan 2016
Mycophenolate mofetil (MMF) is a widely used drug in combination with a calcineurin inhibitor and often cyclosporine (CsA), in preventing GVHD.
Targeting myocardial reperfusion injuries with cyclosporine in the CIRCUS Trial - Pharmacological reasons for failure.
Pathak et al., Strasbourg, France. In Fundam Clin Pharmacol, Jan 2016
The mPTP blocker, cyclosporine A (CsA), has been shown to give protection against reperfusion-induced myocardial necrosis and troubles generated by acute coronary artery repermeabilization.
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines.
Zákány et al., Debrecen, Hungary. In Int J Oncol, Jan 2016
The amount of HA was reduced upon the inhibition of calcineurin with cyclosporine A (CsA), while the inhibition of ERK1/2 with PD098059 elevated it in both cell lines.
Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway.
Zhu et al., Nantong, China. In Front Biosci, Dec 2015
Results showed that phenylephrine promoted CF proliferation, which was abolished by α1-adrenergic receptor antagonist (prazosin), a blocker of Ca(+2) influx (nifedipine), an intracellular Ca(2+) buffer (BAPTA-AM), CaN inhibitors (cyclosporin A and FK506), and over-expression of dominant negative CaN. Phenylephrine activated CaN and evoked NFAT3 nuclear translocation, both of which were blocked by cyclosporine A (CsA) or over-expression of dominant negative CaN.
[Extracellular splitting pattern of mitochondria and the depressant effects of CsA on the process].
Sun et al., In Zhongguo Gu Shang, Nov 2015
OBJECTIVE: To investigate extracellular splitting pattern of mitochondria and the depressant effects of CsA on the process and explore the mechanism of post-traumatic SIRS and its therapeutic strategy.
Systemic cyclosporine and corneal transplantation.
Manzouri et al., Manchester, United Kingdom. In Int Ophthalmol, Nov 2015
One of the most promising immunomodulatory substances whose immunosuppressive effect has revolutionized solid organ transplantation is cyclosporine (CsA).
NFAT-regulated gene expression as predictive biomarker of personal response to calcineurin inhibitors.
Giese et al., Heidelberg, Germany. In Ther Drug Monit, Sep 2015
This assay is based on the quantitative analysis of IL-2, IFNγ and granulocyte macrophage colony-stimulating factor (GM-CSF) gene expression in whole blood samples collected at the time CsA/Tac troughs (C0) and 2 hours after oral uptake (C2).
Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients.
Fan et al., Chengdu, China. In Cochrane Database Syst Rev, 2014
Although immunosuppressive treatment using drugs such as calcineurin inhibitors (CNIs, such as cyclosporin A (CsA) or tacrolimus) reduce acute rejection rates, long-term allograft survival rates are not significantly enhanced.
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines.
Anne Böttger et al., West Chester, United States. In Biochem Biophys Res Commun, 2012
these data reveal the characteristic cytoplasmic sequestration of p53 by the heat shock protein mortalin in human colorectal adenocarcinoma cell lines, as is the case for other cancers, such as glioblastomas and hepatocellular carcinomas.
Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.
Laan et al., Tartu, Estonia. In Mol Cell Endocrinol, 2012
results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism.
The DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.
Silberg et al., Houston, United States. In Protein Sci, 2012
DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9.
Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Cockayne syndrome protein A in complex with DNA damage-binding protein 1.
Pannu et al., Leiden, Netherlands. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
crystals of CSA-DDB1 had unit-cell parameters a = b = 142.03, c = 250.19 A and diffracted to 2.9 A resolution on beamline ID14-1
CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.
Proietti-De-Santis et al., Viterbo, Italy. In Cell Cycle, 2011
CSA and CSB are identified as the key elements of a regulatory mechanism that equilibrate beneficial and detrimental effects of p53 activity upon cellular stress.
Immunological induction with thymoglobulin: reduction in the number of doses in renal transplant from deceased donor.
Pacheco-Silva et al., São Paulo, Brazil. In Einstein (sao Paulo), 2011
In relation to the inhibitor of calcineurin, the relation Tac/Csa was 14.6/66.7% in Group 1, 78.9/12.3% in Group 2 and 100/0% in Group 3. Reflecting the increase in cold ischemia time, the incidence of delayed graft function was 64.6%, 68.4% e 82.1% in Groups 1, 2 and 3, respectively (p = ns).
Opposing roles for calcineurin and ATF3 in squamous skin cancer.
Dotto et al., United States. In Nature, 2010
Calcineurin inhibitors such as cyclosporin A (CsA) are the mainstay of immunosuppressive treatment for organ transplant recipients.
The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A.
Mundel et al., Miami, United States. In Nat Med, 2008
The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells.
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia.
Ghysdael et al., Orsay, France. In Nat Med, 2007
The critical role of calcineurin in the immune response is underscored by the fact that calcineurin inhibitors, such as cyclosporin A (CsA) and FK506, are powerful immunosuppressants in wide clinical use.
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.
Moncada et al., London, United Kingdom. In Nat Cell Biol, 2004
Cytoprotection is abolished after treatment with cyclosporin A (CsA), which disrupts mitochondrial calcium signalling, or with the calcium chelator BAPTA-AM.
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.
Bonaldo et al., Padova, Italy. In Nat Genet, 2003
These defects were reversible, as they could be normalized by plating Col6a1-/- myofibers on collagen VI or by addition of cyclosporin A (CsA), the inhibitor of mitochondrial permeability transition pore (PTP).
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