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Dihydropyrimidinase-like 5

This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CV2, MM2, Amphiphysin, HAD, CAN
Papers on CRMP5
Pitfalls in the detection of CV2 (CRMP5) antibodies.
Graus et al., Barcelona, Spain. In J Neuroimmunol, Feb 2016
The 4 samples were positive by immunofluorescence on HEK293 cells transfected with CRMP5 and immunoblot of these cells lysate.
Paraneoplastic subacute lower motor neuron syndrome associated with solid cancer.
Attarian et al., Marseille, France. In J Neurol Sci, Dec 2015
The neurological symptoms preceded the diagnosis of a breast adenocarcinoma and a thymoma in the first two patients, one of them with anti-CV2/CRMP5 antibodies.
CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.
Thomasset et al., Lyon, France. In Cancer Res, Oct 2015
Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that play a major role in nervous system development.
Clinical and Histological Features of Small Cell Lung Cancer Paraneoplastic Inflammatory Uveitis.
Graham et al., London, United Kingdom. In Ocul Immunol Inflamm, Sep 2015
PURPOSE: Paraneoplastic ocular inflammation can be associated with the autoantibody against collapsin response-mediator protein-5 (anti-CRMP-5).
Erratum: Encephalomyeloneuropathy with CRMP-5 antibodies in a patient with a primary mediastinal serinoma.
In Neurol Neuroimmunol Neuroinflamm, Aug 2015
[This corrects the article on p. e82 in vol.
Paraneoplastic neurologic disorders in small cell lung carcinoma: A prospective study.
Maddison et al., Oxford, United Kingdom. In Neurology, Aug 2015
Other neuronal antibodies were found at lower frequencies (GABAb receptor [12.5%] and N-type VGCC [20.8%]) or very rarely (GAD65, amphiphysin, Ri, CRMP5, Ma2, Yo, VGKC complex, CASPR2, LGI1, and NMDA receptor [all <5%]).
"Non-classical" paraneoplastic neurological syndromes associated with well-characterized antineuronal antibodies as compared to "classical" syndromes - More frequent than expected.
Stich et al., Freiburg, Germany. In J Neurol Sci, Jun 2015
METHODS: We retrospectively investigated medical records from consecutive patients diagnosed with definite PNS and serological evidence of well-characterized onconeural antibodies (anti-Hu, Yo, Ri, CV2/CRMP5, Ma1, Ma2, and amphiphysin) analyzed between 1991 and 2014 in our clinic.
An 8-year old boy with continuous spikes and waves during slow sleep presenting with positive onconeuronal antibodies.
Zou et al., Beijing, China. In Eur J Paediatr Neurol, Mar 2015
Although the patient's neuroblastoma had been successfully treated 8 years prior to presentation and an extensive workup did not show a tumor reoccurrence, testing for onconeuronal antibodies was positive for anti-Ma2 and anti-CV2/CRMP5 antibodies.
Small cell lung cancer and progressive retinopathy.
Maemondo et al., Japan. In Bmj Case Rep, 2013
It has been reported that anti-CV2/CRMP5 antibodies are present in patients with neoplasms accompanied by retinopathy as well as optic neuritis.
Paraneoplastic disorders of the peripheral nervous system.
Camdessanché et al., Saint-Étienne, France. In Presse Med, 2013
With solid tumour, antibodies directed to intracellular (anti-Hu or anti-CV2/CRMP5 antibodies) or surface antigens (anti-VGCC,or LGI1 and Caspr2 antibodies) have been identified while with lymphoma, the neuropathy is usually linked to a monoclonal gammopathy.
[Autoantibodies associated with autoimmune-mediated cerebellar ataxia].
Nanri et al., Tokyo, Japan. In Brain Nerve, 2013
Anti-Yo, -Zic, -CARPVIII, -Tr, -Ri, -Hu, -Ma, -CRMP-5, -ANNA-3, -PCA-2, -VGCC, and -mGluR antibodies (Abs) are found in paraneoplastic cerebellar ataxia, whereas anti-GAD, -thyroid, and -gliadin Abs are found in non-paraneoplastic cerebellar ataxia.
Paraneoplastic neurological syndromes.
Dalmau et al., Barcelona, Spain. In Curr Opin Neurol, 2012
Isolated myelopathy may have a paraneoplastic origin associated with amphiphysin or CV2 (CRMP5) antibodies.
Paraneoplastic neuropathy.
Sobue et al., Nagoya, Japan. In Handb Clin Neurol, 2012
Various onconeural antibodies, including anti-Hu, anti-CV2/CRMP-5, and anti-ganglionic acetylcholine receptor antibodies, are associated with neuropathy.
The collapsin response mediator protein 5 onconeural protein is expressed in Schwann cells under axonal signals and regulates axon-Schwann cell interactions.
Antoine et al., Saint-Étienne, France. In J Neuropathol Exp Neurol, 2012
CRMP5-deficient mice show abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons.
Paraneoplastic encephalomyelopathies: pathology and mechanisms.
Pittock et al., Rochester, United States. In Acta Neuropathol, 2011
Disorders accompanied by autoantibody markers of neural peptide-specific cytotoxic effector T cells [such as anti-neuronal nuclear antibody type 1 (ANNA-1, aka anti-Hu), Purkinje cell antibody type 1 (PCA-1, aka anti-Yo) and CRMP-5 IgG] are generally poorly responsive to immunotherapy.
Antineuronal autoantibodies in neurological disorders.
Bürk, In Biomol Concepts, 2011
Autoantibodies (abs) related to neurological disease are currently classified into two large groups depending on the site of the respective target antigen: Group I encompasses abs that recognise intracellular antigens (Hu, Yo, Ri, CV2/CRMP5, amphiphysin, Ma2, SOX, ZIC, GAD, adenylate kinase 5, homer 3), whereas group II abs are targeted against neuronal cell membrane antigens (VGKC, AMPA-R, GABAB-R, NMDA-R, Glycine-R, VGCC, metabotropic GluR1).
CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.
Goshima et al., Yokohama, Japan. In J Neurosci, 2011
Data show that CRMP5 is involved in the development, maintenance and synaptic plasticity of Purkinje cells.
CRMP5 regulates generation and survival of newborn neurons in olfactory and hippocampal neurogenic areas of the adult mouse brain.
Jourdan et al., Lyon, France. In Plos One, 2010
These findings provide the first evidence that CRMP5 is involved in the generation and survival of newly generated neurons in areas of the adult brain with a high level of activity-dependent neuronal plasticity.
CRMP5 interacts with tubulin to inhibit neurite outgrowth, thereby modulating the function of CRMP2.
Moradi-Améli et al., Lyon, France. In J Neurosci, 2010
The CRMP5 binding to tubulin modulates CRMP2 regulation of neurite outgrowth and neuronal polarity during brain development.
Identification of functional marker proteins in the mammalian growth cone.
Igarashi et al., Niigata, Japan. In Proc Natl Acad Sci U S A, 2009
Results provide marker proteins Gap-43 and newly identified candidate neuronal growth-associated proteins MAP1B, CRMP5, crmp5 and catenins.
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