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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cysteine-rich secretory protein LCCL domain containing 2

CRISPLD2, Lgl1, cysteine-rich secretory protein LCCL domain containing 2
Top mentioned proteins: LIP, V1a, POLYMERASE, mgl-1, ACID
Papers on CRISPLD2
HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis.
Liu et al., Changsha, China. In Mol Immunol, Jan 2016
Herein, we introduced a recently established anti-LPS protein cysteine-rich secretory protein LCCL domain containing 2 (CRISPLD2) to investigate endogenous protection mechanism of HMGB1 induced inflammatory response.
Crispld2 is required for neural crest cell migration and cell viability during zebrafish craniofacial development.
Hecht et al., Houston, United States. In Genesis, Oct 2015
The CAP superfamily member, CRISPLD2, has previously been shown to be associated with nonsyndromic cleft lip and palate (NSCLP) in human populations and to be essential for normal craniofacial development in the zebrafish.
Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex.
Ohno et al., Yokohama, Japan. In Mol Biol Cell, Aug 2015
Here we show that depletion of Lgl1 and Lgl2 in MDCK epithelial cells results in overproliferation and overproduction of Lgl2 causes G1 arrest.
[Phenotype predictions of the pathogenic nonsynonymous single nucleotide polymorphisms in deafness-causing gene COCH].
Xin et al., Nanjing, China. In Yi Chuan, Jul 2015
COCH encodes cochlin, which contains an N-terminal LCCL (Limulus factor C, cochlin, and late gestation lung protein Lgl1) domain and a C-temimal vWFA (Von Willebrand factor type A) domain.
Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation.
Dhodapkar et al., New Haven, United States. In Blood, Mar 2015
Here, we report that β-glucosylceramide 22:0 (βGL1-22) and glucosylsphingosine (LGL1), 2 major sphingolipids accumulated in GD, can be recognized by a distinct subset of CD1d-restricted human and murine type II natural killer T (NKT) cells.
LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts.
Kaplan et al., Montréal, Canada. In Am J Physiol Lung Cell Mol Physiol, Mar 2015
Temporal or spatial deficiency of late-gestation lung 1/cysteine-rich secretory protein LD2 (LGL1/CRISPLD2), expressed in and secreted by lung fibroblasts, can impair both lung branching and alveogenesis (LGL1 denotes late gestation lung 1 protein; LGL1 denotes the human gene; Lgl1 denotes the mouse/rat gene).
Preliminary evidence of an interaction between the CRISPLD2 gene and non-syndromic cleft lip with or without cleft palate (nsCL/P) in Xinjiang Uyghur population, China.
Moming et al., Ürümqi, China. In Int J Pediatr Otorhinolaryngol, Feb 2015
Single nucleotide polymorphisms (SNPs) of CRISPLD2 gene have been found to be an etiologic factor in the development of nsCL/P.
Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows.
Wathes et al., United Kingdom. In Animals (basel), 2014
These were predominantly associated with tissue turnover (e.g., BRINP1, FOXG1), immune function (e.g., IL17RB, CRISPLD2), inflammation (e.g., C3, SERPINF1, SERPINF2) and lipid metabolism (e.g., SCAP, ACBD5, SLC10A).
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.
Ji et al., Xinxiang, China. In J Cancer, 2014
In particular, we reviewed the involvement of several critical genes, including Lkb1, claudin-4, claudin-7, Par3, Lgl1, E-cadherin, and the Scnn1 gene family.
Inhibition of glioblastoma malignancy by Lgl1.
Lorimer et al., Ottawa, Canada. In Oncotarget, 2014
Recently we have shown that a human homolog of Lgl, Lgl1 (LLGL1), is constitutively phosphorylated and inactivated in glioblastoma cells; this occurs as a downstream consequence of PTEN loss, one of the most frequent genetic events in glioblastoma.
BMP4 and LGL1 are Down Regulated in an Ovine Model of Congenital Diaphragmatic Hernia.
Bütter et al., London, Canada. In Front Surg, 2013
The Wnt signaling pathway and downstream targets, such as bone morphogenetic proteins (BMP) 4 and other factors such as late gestation lung protein 1 (LGL1), are essential to normal lung development.
The tumor suppressor Lgl1 regulates front-rear polarity of migrating cells.
Ravid, Canada. In Cell Adh Migr, 2013
Recently, we showed that the mammalian Lgl1 interacts directly with non-muscle myosin IIA (NMIIA), inhibiting its ability to assemble into filaments in vitro.
Uncorking gastrulation: the morphogenetic movement of bottle cells.
Lee, Berkeley, United States. In Wiley Interdiscip Rev Dev Biol, 2012
The Nodal signaling pathway, Wnt5a, and Lgl1 are all required for bottle cell formation, but how they induce subcellular changes resulting in apical constriction remains to be elucidated.
The CRISPLD2 gene is involved in cleft lip and/or cleft palate in a Chinese population.
Yu et al., Lanzhou, China. In Birth Defects Res A Clin Mol Teratol, 2011
CRISPLD2 gene contributes to the etiology of NSCLP in the Northwestern Chinese population. SNP rs1546124 is significantly related to NSCLP, associated with both CL/P and CPO groups, and SNP rs4783099 is significantly associated with CPO.
No evidence for a role of CRISPLD2 in non-syndromic cleft lip with or without cleft palate in an Italian population.
Scapoli et al., Bologna, Italy. In Eur J Oral Sci, 2011
the present investigation did not support the hypothesis of the involvement of CRISPLD2 in nonsyndromic cleft lip and palate
Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.
Hecht et al., Houston, United States. In Birth Defects Res A Clin Mol Teratol, 2011
These novel findings suggest that CRISPLD1 plays a role in Nonsyndromic cleft lip and palate (NSCLP) through the interaction with CRISPLD2 and folate pathway genes.
CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population.
Cao et al., Harbin, China. In Eur J Oral Sci, 2010
three SNPs in northern Chinese population found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility.
The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function.
Han et al., Shanghai, China. In J Immunol, 2009
present work introduces mammal CRISPLD2 as a major serum protein that acts as a natural LPS antagonist and promises to be of considerable preventative value against endotoxic shock.
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.
O'Bryan et al., Australia. In Endocr Rev, 2008
The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.
Molecular basis of Mendelian idiopathic epilepsies.
Gardiner et al., London, United Kingdom. In Ann Med, 2003
The two non-ion-channel genes, LGl1 causing autosomal dominant lateral temporal lobe epilepsy and MASS1 causing febrile and afebrile seizures, both contain a novel repeat motif variously called the epilepsy-associated repeat (EAR) and epitempin (EPTP) repeat.
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