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V-set and immunoglobulin domain containing 4

CRIg, Z39Ig, VSIG4, Ig superfamily protein
This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: CAN, SET, HAD, CD4, V1a
Papers on CRIg
Proteomics of ionomycin-induced ascidian sperm reaction: Released and exposed sperm proteins in the ascidian Ciona intestinalis.
Sawada et al., Toba, Japan. In Proteomics, Dec 2015
Among the surface proteins XP_009859314.1 (uncharacterized protein exhibiting homology to HrTTSP-1) was most abundant before the sperm reaction, but XP_004227079.1 (unknown Ig superfamily protein) appears to be most abundantly exposed by the sperm reaction.
An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice.
Harris et al., Cardiff, United Kingdom. In Proc Natl Acad Sci U S A, Dec 2015
We describe a targeted complement inhibitor, comprising complement receptor of the Ig superfamily (CRIg) fused with complement regulator CD59a, designed to inhibit membrane attack complex (MAC) assembly at sites of C3b/iC3b deposition.
Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells.
Morita et al., Iowa City, United States. In J Immunol, Dec 2015
The Ig superfamily protein butyrophilin (BTN)3A1 was shown to be required for prenyl pyrophosphate stimulation.
Complement receptor of the immunoglobulin superfamily reduces murine lupus nephritis and cutaneous disease.
Tsokos et al., Boston, United States. In Clin Immunol, Oct 2015
Complement receptor of the immunoglobulin superfamily (CRIg) is a selective inhibitor of the alternative pathway of complement and a soluble form reverses established inflammation and bone destruction in experimental autoimmune arthritis.
Endogenous VSIG4 negatively regulates the helper T cell-mediated antibody response.
Choi et al., Pusan, South Korea. In Immunol Lett, Jun 2015
VSIG4 acts as a co-inhibitory ligand to negatively regulate T cell proliferation and cytokine production, and its expression is restricted to macrophages.
Right ventricular myocardial biomarkers in human heart failure.
Hemnes et al., Taipei, Taiwan. In J Card Fail, May 2015
In an unbiased approach, the top 10 DEGs SERPINA3, SERPINA5, LCN6, LCN10, STEAP4, AKR1C1, STAC2, SPARCL1, VSIG4 and F8 exhibited no overlap in read counts between DON and HF RVs, high sensitivities, specificities, predictive values and areas under the receiver operating characteristic curves.
Protein kinase cα regulates the expression of complement receptor Ig in human monocyte-derived macrophages.
Ferrante et al., Adelaide, Australia. In J Immunol, Apr 2015
The complement receptor Ig (CRIg) is selectively expressed by macrophages.
Detection of Selection Signatures on the X Chromosome in Three Sheep Breeds.
Du et al., Beijing, China. In Int J Mol Sci, 2014
We also identified some selection regions harboring genes that had human orthologs, including BKT, CENPI, GUCY2F, MSN, PCDH11X, PLP1, VSIG4, PAK3, WAS, PCDH19, PDHA1, and SRPX2.
VSIG4 is highly expressed and correlated with poor prognosis of high-grade glioma patients.
Chen et al., Shanghai, China. In Am J Transl Res, 2014
The V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a complement receptor for C3b/iC3b and inhibits cytotoxic T lymphocytes activation, which may play important roles in glioma oncogenesis.
A novel CRIg-targeted complement inhibitor protects cells from complement damage.
Hu et al., Suzhou, China. In Faseb J, 2014
In addition, complement receptor of the immunoglobulin superfamily (CRIg) has been demonstrated to inhibit AP and, more notably, still specifically binds to C3b/iC3b.
Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.
Matsuyama et al., Kagoshima, Japan. In Innate Immun, 2012
we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine
Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.
Mathis et al., Boston, United States. In Nat Immunol, 2012
We exploited this approach to identify previously unknown molecular and cellular elements correlated with disease protection, including the complement receptor of the immunoglobulin superfamily (CRIg), which marked a subset of macrophages associated with diabetes resistance.
Down-regulation of Z39Ig on macrophages by IFN-gamma in patients with chronic HBV infection.
Wu et al., Chongqing, China. In Clin Immunol, 2010
These results suggest that T cells can opposite T cell hyporesponsiveness through dampening Z39Ig inhibitory signals from macrophages and thus maintain their anti-viral function in chronic hepatitis B.
[Effects of costimulatory molecule VSIG4 exclusively expression in macrophage on renal interstitial fibrosis].
Yuan et al., Chongqing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2010
The interstitial inflammatory cell infiltration and tubular lesion of VSIG4(-/-); urethral obstruction operation mice were increased, with the expression of TGF-beta1 increased and MMP-2 reduced. VSIG4 may play a role in inhibiting interstitial fibrosis.
Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus.
Wu et al., Chongqing, China. In Immunol Lett, 2010
hVSIG4 recombinant adenovirus-transfected DCs suppress T cell proliferation, cytokine production and activation marker expression with
Para-inflammation in the aging retina.
Forrester et al., Aberdeen, United Kingdom. In Prog Retin Eye Res, 2009
With age, para-inflammatory changes have also been observed in the choroidal tissue, evidenced by 1) increased thickness of choroid; 2) increased number of CD45(+)CRIg(+) macrophages; 3) morphological abnormalities in choroidal melanocytes; and 4) fibrosis in choroidal tissue.
Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages.
van Lookeren Campagne et al., San Francisco, United States. In J Immunol, 2009
CRIg thus identifies a subset of tissue resident macrophages capable of increased phagocytosis of complement C3-coated particles, a function critical for immune clearance
A role of macrophage complement receptor CRIg in immune clearance and inflammation.
van Lookeren Campagne et al., San Francisco, United States. In Mol Immunol, 2008
Complement receptor of the immunoglobulin superfamily (CRIg), also referred to as Z39Ig and V-set and Ig domain-containing 4 (VSIG4), has recently been implicated in the clearance of systemic pathogens and autologous cells.
Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
van Lookeren Campagne et al., San Francisco, United States. In Nature, 2006
CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases
CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.
van Lookeren Campagne et al., San Francisco, United States. In Cell, 2006
Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b.
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