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CAMP responsive element binding protein 3-like 2

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: FUS, CAN, POLYMERASE, HAD, MUC4
Papers on CREB3L2
Cytogenetically confirmed low-grade fibromyxoid sarcoma arising from the tibia.
Zhang et al., Philadelphia, United States. In Hum Pathol, Feb 2016
This diagnosis often hinges on the presence of the hallmark cytogenetic aberration, a balanced 7;16 translocation resulting in a FUS-CREB3L2 fusion gene.
DOG1 Expression in Low-Grade Fibromyxoid Sarcoma: A Study of 11 Cases, With Molecular Characterization.
Fisher et al., Ipswich, United Kingdom. In Int J Surg Pathol, Sep 2015
After referral to a tertiary center, repeat DOG1 immunohistochemistry again showed diffuse expression, but MUC4 was also positive, and this was confirmed to be LGFMS, harboring FUS-CREB3L2 fusion transcripts by reverse transcription-polymerase chain reaction and FUS rearrangement with fluorescence in situ hybridization.
Low-Grade Fibromyxoid Sarcoma of the Head and Neck: A Clinicopathologic Series and Review of the Literature.
Bishop et al., Baltimore, United States. In Head Neck Pathol, Sep 2015
Most LGFMSs harbor a characteristic gene fusion of FUS-CREB3L2, and recently MUC4 immunostaining has been found to be highly sensitive and specific for the diagnosis.
RNA sequencing of sarcomas with simple karyotypes: identification and enrichment of fusion transcripts.
Mertens et al., Lund, Sweden. In Lab Invest, Jun 2015
Three novel (KIAA2026-NUDT11, CCBL1-ARL1, and AFF3-PHF1) and two previously known fusions (FUS-CREB3L2 and HAS2-PLAG1) were found and could be verified by other methods.
Pediatric low-grade fibromyxoid sarcoma mimicking ossifying fibromyxoid tumor: adding to the diagnostic spectrum of soft tissue tumors with a bony shell.
Fisher et al., London, United Kingdom. In Hum Pathol, Mar 2015
We describe a case of superficial low-grade fibromyxoid sarcoma (LGFMS) in a 12-year-old boy, confirmed by the detection of FUS-CREB3L2 fusion transcripts by reverse-transcription polymerase chain reaction and FUS rearrangement with fluorescence in situ hybridization, which had morphological features similar to ossifying fibromyxoid tumor (OFMT), including an almost complete rim of mature, metaplastic bone.
[Bone and Calcium Research Update 2015. The regulation of proliferation and differentiation by the ER stress transducer in chondrocytes].
Imaizumi, Hiroshima, Japan. In Clin Calcium, 2015
BBF2H7 is an ER-resident transmembrane transcription factor which is structurally similar to ATF6, one of the canonical ER stress transducers, and preferentially expresses in chondrocytes.
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Molnár et al., Budapest, Hungary. In Plos One, 2014
Promotion of Cancer Cell Proliferation by Cleaved and Secreted Luminal Domains of ER Stress Transducer BBF2H7.
Imaizumi et al., Hiroshima, Japan. In Plos One, 2014
BBF2H7 is an endoplasmic reticulum (ER)-resident transmembrane basic leucine zipper (bZIP) transcription factor that is cleaved at the transmembrane domain by regulated intramembrane proteolysis in response to ER stress.
Physiological functions of endoplasmic reticulum stress transducer OASIS in central nervous system.
Saito, Hiroshima, Japan. In Anat Sci Int, 2014
These membrane-bound bZIP transcription factors include OASIS, BBF2H7 CREBH, CREB4 and Luman, and are collectively referred to as OASIS family members.
A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion.
Saito et al., Tokyo, Japan. In Int J Surg Case Rep, 2013
Reverse transcription polymerase chain reaction from a formalin-fixed, paraffin-embedded biopsy specimen revealed a FUS-CREB3L2 gene fusion (exon6/int/exon5), leading to the diagnosis of LGFMS.
Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature.
Saito et al., Tokyo, Japan. In Diagn Pathol, 2013
Despite the young age, this patient was accurately diagnosed by the typical histology and the detection of a FUS-CREB3L2 gene fusion.
BBF2H7-mediated Sec23A pathway is required for endoplasmic reticulum-to-Golgi trafficking in dermal fibroblasts to promote collagen synthesis.
Tsuji-Naito et al., Chiba, Japan. In J Invest Dermatol, 2012
the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis
Regulation of endochondral ossification by transcription factors.
Yoneda et al., Suita, Japan. In Front Biosci, 2011
A transcription factor, BBF2H7, functions as an ER stress sensor in chondrocytes through regulation of appropriate secretion of chondrogenic matrices.
Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature.
O'Connell et al., Vancouver, Canada. In Hum Pathol, 2011
Subsequently, it was discovered to carry the recurrent chromosomal translocation t(7;16)(q33;p11) encoding a FUS-CREB3L2 fusion oncoprotein.
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
Mertens et al., Lund, Sweden. In Clin Cancer Res, 2011
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity.
Andrew et al., Baltimore, United States. In J Cell Biol, 2010
The human Creb3L2 can activate SPCG transcription in a heterologous system(Drosophila embryos), which suggests a general and direct role for this family of bZip transcription factors in mediating high-level secretory capacity.
Characterization of an alternative transcript of the human CREB3L2 gene.
Mertens et al., Lund, Sweden. In Oncol Rep, 2010
We characterized a widely expressed transcript of CREB3L2 generated by an intronic polyadenylation site in intron 4 of the gene.
Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma.
Mertens et al., Lund, Sweden. In Cancer Genet Cytogenet, 2010
Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome is associated with low-grade fibromyxoid sarcoma.
A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.
Green et al., Worcester, United States. In Nat Med, 2010
Our results reveal an essential survival pathway in malignant glioma, whereby activation of a RAS-mitogen-activated protein kinase or phosphoinositide-3-kinase signaling cascade leads to induction of the transcription factor cAMP response element-binding protein-3-like-2 (CREB3L2), which directly activates ATF5 expression.
Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.
Imaizumi et al., Miyazaki, Japan. In Nat Cell Biol, 2009
BBF2H7 (BBF2 human homologue on chromosome 7), an ER-resident basic leucine zipper transcription factor, is activated in response to ER stress and is highly expressed in chondrocytes.
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