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CAMP responsive element binding protein 1

CREB, cAMP response element binding protein
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Brain-derived neurotrophic factor, ERK, Akt
Papers using CREB antibodies
A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Chandra Dhyan, In PLoS ONE, 2006
... The survivin, TGFβRI, AKT, Smad3, pSmad3, CREB, and IκBα antibodies as well as the PKA inhibitor H89 were obtained from Cell Signaling Technology ...
Activation of ERK1/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation
Arellano Rogelio O et al., In Reproductive Biology and Endocrinology : RB&E, 2005
... Antibodies against mouse total or phosphorylated MAPK p44 and p42 and total or phosphorylated CREB were from Cell Signaling (Danvers, MA), and antibody ...
Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.
Landsberger Nicoletta, In PLoS ONE, 2003
... Anti-CREB antibody was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility.
Ludgate Marian, In PLoS ONE, 2003
... Anti-phospho CREB Abs were from Millipore (Temecula, CA), and those against CREB and EP2 came from Cell Signaling (Boston, MA) and Abcam ...
Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts
Bab Itai et al., In Journal of Bone and Mineral Research, 2003
... The EZ-ChIP kit was purchased from Upstate Millipore (Billerica, MA, USA), and anti-phospho-CREB (on serine 133) antibody was from Cell Signaling Technologies ...
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Papers on CREB
Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory.
Gould et al., Philadelphia, United States. In Physiol Behav, Apr 2016
Hippocampal kinases such as cAMP-dependent protein kinase (PKA), calcium/calmodulin-dependent protein kinases (CAMKs), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and c-jun N-terminal kinase 1 (JNK1), and the transcription factor cAMP-response element-binding protein (CREB) that are activated either directly or indirectly by nicotine may modulate hippocampal plasticity and in parallel hippocampus-dependent learning and memory.
Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model.
Zhang et al., Shanghai, China. In Neurosci Bull, Feb 2016
Corresponding to the behavior changes, the plasma corticosterone and phosphorylated cAMP response element binding protein levels were decreased in the nucleus accumbens of the mice that experienced isolation.
Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy.
Pierattelli et al., Florence, Italy. In Biophys J, Feb 2016
ID4 is the fourth intrinsically disordered linker of CREB-binding protein (CBP).
Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
Xie et al., Nanjing, China. In Oncol Rep, Feb 2016
Western blot analysis showed that activation of phosphorylation of Akt, ERK1/2, CREB and the expression of Snail increased, while the expression of E-cadherin decreased after the activation of NLRP3 inflammasome.
Resetting the epigenome for heart regeneration.
Hudson et al., Brisbane, Australia. In Semin Cell Dev Biol, Feb 2016
BMP, bone morphogenetic protein; Bvht, Braveheart; CBP, CREB-binding protein; Cdkn, cyclin dependent kinase inhibitor; DOT1L, disruptor of telomeric silencing-1; DNMTs, DNA methyltransferases; eRNAs, enhancer RNAs; ESCs, embryonic stem cells; FGF, fibroblast growth factor; FOX, Forkhead box; Gcn5, general control of amino acid synthesis protein 5; HATs, histone acetyl transferases; HDACs, histone deacteylases; H3K27, histone 3, lysine 27; HMTs, histone methyltransferases; Jmj, Jumonji; JMJD3, Jumonji domain-containing protein 3; KDMs, histone lysine demethylases; lncRNAs, long non-coding RNAs; Mhrt, Myheart; miRNAs, microRNAs; Myh, myosin heavy chain; PRC2, polycomb repressive complex 2; PSCs, pluripotent stem cells; PTM, post-translational modification; SIRTs, Sirtuins; SMYD1, SET and MYND domain containing 1; Srf, serum response factor; TET, Ten-eleven translocation; TGF-β, transforming growth factor beta; TFs, transcription factors; UTX, ubiquitously transcribed tetratricopeptide repeat, X chromosome.
Role of the cAMP Pathway in Glucose and Lipid Metabolism.
Montminy et al., Los Angeles, United States. In Handb Exp Pharmacol, Feb 2016
Many of these effects appear to be mediated at the transcriptional level, in part through the activation of the transcription factor CREB and its coactivators.
Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function".
Nestler, New York City, United States. In Brain Res, Jan 2016
Specifically, opiates in several CNS regions including NAc, and cocaine more selectively in NAc, induce expression of certain adenylyl cyclase isoforms and PKA subunits via the transcription factor, CREB, and these transcriptional adaptations serve a homeostatic function to oppose drug action.
Signal integration by Ca(2+) regulates intestinal stem-cell activity.
Jasper et al., Novato, United States. In Nature, Jan 2016
High cytosolic Ca(2+) concentrations induce ISC proliferation by regulating Calcineurin and CREB-regulated transcriptional co-activator (Crtc).
Brain-derived neurotrophic factor and its clinical implications.
Das et al., Vishākhapatnam, India. In Arch Med Sci, Jan 2016
BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.
Modulation of neurotrophic signaling pathways by polyphenols.
Firuzi et al., Shīrāz, Iran. In Drug Des Devel Ther, Dec 2015
Increased expression of neurotrophic factors in vitro and in vivo is the mechanism of neurotrophic action of flavonoids such as scutellarin, daidzein, genistein, and fisetin, while compounds like apigenin and ferulic acid increase cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation.
Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport.
Rissman et al., San Diego, United States. In Plos One, Dec 2015
Furthermore, while both acute and chronic CRF treatment led to significant reduction in CREB activation and axon transport of brain-derived neurotrophic factor (BDNF), this was not the case with mitochondrial transport.
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Wang et al., Beijing, China. In Nature, Sep 2015
Here we show in mice that CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR signalling to modulate COPII-dependent SREBP1 processing.
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Pahan et al., Chicago, United States. In Cell Metab, Sep 2015
Upon binding, statins upregulate neurotrophins via PPARα-mediated transcriptional activation of cAMP-response element binding protein (CREB).
Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway.
Vasavada et al., New York City, United States. In Cell Metab, Aug 2015
Mechanistically, osteoprotegerin induced human and rodent β-cell replication by modulating CREB and GSK3 pathways, through binding Receptor Activator of NF-κB (RANK) Ligand (RANKL), a brake in β-cell proliferation.
The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.
Zhang et al., Dallas, United States. In Nat Cell Biol, May 2015
LAIR1 induces activation of SHP-1, which acts as a phosphatase-independent signalling adaptor to recruit CAMK1 for activation of downstream CREB in AML cells.
Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells.
Ammit et al., Sydney, Australia. In Biochim Biophys Acta, 2012
By increasing MKP-1 expression via parallel p38 MAPK- and CREB-mediated pathways, S1P temporally regulates MAPK signaling pathways by upregulating the negative feedback controller MKP-1.
Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages.
Chong et al., Seoul, South Korea. In Exp Neurol, 2012
The effect of norepinephrine on amyloid beta(1-42) peptide-induced responses in migroglia-like THP-1 cells is contingent on cyclic AMP/protein kinase (PK)A pathways and cAMP responsive element binding protein (CREB) activation.
Sox4 cooperates with CREB in myeloid transformation.
Sakamoto et al., Los Angeles, United States. In Blood, 2012
Sox4 and CREB cooperate and contribute to increased proliferation of hematopoietic progenitor cells.
Phytoestrogen genistein up-regulates endothelial nitric oxide synthase expression via activation of cAMP response element-binding protein in human aortic endothelial cells.
Liu et al., Blacksburg, United States. In Endocrinology, 2012
genistein may play a beneficial role in vascular function through targeting the PKA/CREB/eNOS/NO signaling pathway
Ca(V)1 and Ca(V)2 channels engage distinct modes of Ca(2+) signaling to control CREB-dependent gene expression.
Tsien et al., Stanford, United States. In Cell, 2012
Study compared the impact of various Ca2+ channels in supporting Ca2+ entry, bulk [Ca2+]i rises, and changes in cAMP response element-binding protein (CREB) phosphorylation and gene expression. The efficacy of signaling via CaV1 and CaV2 channels differs markedly for a given depolarization and even for the same rise in bulk [Ca2+].
More papers using CREB antibodies
Solid-phase synthesis of kojic acid-tripeptides and their tyrosinase inhibitory activity, storage stability, and toxicity
Kim Dong-Seok et al., In The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2003
... Antibodies specific for phospho-ERK1/2 (Thr202/Tyr204, #9101S) and phospho-CREB (Ser133, #9198) were obtained from Cell Signaling Technology (Beverly, MA, USA) ...
Successful recollection of remote autobiographical memories by amnesic patients with medial temporal lobe lesions
Inokuchi Kaoru et al., In Molecular Brain, 2002
... For experiments using inducible cAMP response element binding protein (CREB) repressor transgenic mice [ ...
Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Bate Michael, In PLoS Biology, 2002
... p44/42 mitogen-activated protein kinase (Erk1/2), phospho-p44/42 mitogen-activated protein kinase, AKT, phospho-AKT (Ser473), CREB, and phospho-Ser133 CREB were obtained from Cell Signaling Technology ( ...
Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility.
Williams Simon, In PLoS ONE, 2002
... Mouse monoclonal antibody to cAMP response element-binding protein (CREB) (86B10) and rabbit monoclonal to phosphoCREB-S133-PO4 (87G3) were from Cell Signaling.
Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
Zhuo Min et al., In Molecular Pain, 1999
... Wild-type (wt) pCMV-CREB vector and mutant CMV-CREB133 vector were purchased from Clontech (Cat 6014-1, BD Biosciences ...
Transforming Growth Factor β Blocks Tec Kinase Phosphorylation, Ca2+ Influx, and NFATc Translocation Causing Inhibition of T Cell Differentiation
Ray Anuradha et al., In The Journal of Experimental Medicine, 1998
... Anti-STAT6, anti-GATA-3, anti-NFATc1, anti Txk (Rlk), anti-Oct-1, and anti-CREB-1 were obtained from Santa Cruz Biotechnology, Inc ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Dickenson Anthony H et al., In Molecular Therapy, 1998
... rabbit anti-PSD-95 (1:1,000, ab18258; Abcam, Cambridge, UK), rabbit anti-nNOS (1:3,000, 07-571; Millipore, Billerica, MA), rabbit anti-CREB (1:500, ab5803; Abcam), rabbit anti-P ...
Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms
Lu Bai et al., In The Journal of Cell Biology, 1997
... dnCREB cDNA constructs (K- and A-CREB) were purchased from CLONTECH Laboratories, Inc ...
Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumour necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent
Williams Richard et al., In Arthritis Research & Therapy, 1997
... Antibodies to CREB and phospho-CREB were purchased from New England Biolabs, Beverly, MA, USA ...
Spatiotemporal Dynamics of CREB Phosphorylation: Transient versus Sustained Phosphorylation in the Developing Striatum.
Bartolomucci Alessandro, In PLoS ONE, 1995
... Rabbit p-CREB (Ser133, #9189) and mouse CREB (#9104) were from Cell Signaling Technology (Beverly, MA, USA) ...
Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples.
Lucia Alejandro, In PLoS ONE, 1989
... sc-20981) and anti-p-CREB (sc-101662) antibodies were supplied by Santa Cruz Biotechnology, Inc ...
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