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Retinaldehyde binding protein 1

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CIs, p63, Glial Fibrillary Acidic Protein, CAN, ROD
Papers using CRALBP antibodies
ATP crossing the cell plasma membrane generates an ionic current in Xenopus oocytes
Bringmann Andreas et al., In Purinergic Signalling, 1999
... (1:200; V9 clone, Santa Cruz), mouse anti-glutamine synthetase (1:250, Chemicon) and mouse anti-cellular retinaldehyde-binding protein (CRALBP; 1:1000; Acris).
Papers on CRALBP
First Responders: Dynamics of Pre-Gliotic Müller Cell Responses in The Isolated Adult Rat Retina.
Ghosh et al., Lund, Sweden. In Curr Eye Res, Dec 2015
METHODS: To study pre-gliotic events, we used a model of adult rat retinal explants and related the dynamic expression of GFAP as well as apoptosis, to four key regulators of retinal homeostasis (glutamine synthetase (GS), cellular retinaldehyde binding protein (CRALBP), basic fibroblast growth factor (bFGF), carbonic anhydrase II (CAII)) using immunohistochemistry. RESULTS: We found that a sustained GFAP upregulation couple with gliotic remodeling occurred comparatively late and that this phenomenon was preceded by an initial upregulation followed by depletion of GS, CRALBP, bFGF and CAII in retinal Müller cells.
Effects of low-level laser irradiation on proliferation and functional protein expression in human RPE cells.
Zhang et al., Zhengzhou, China. In Lasers Med Sci, Dec 2015
Moreover, the expression of ZO-1 and CRALBP were evaluated by immunostaining.
Enriched Cultures of Retinal Cells From BJNhem20 Human Embryonic Stem Cell Line of Indian Origin.
Vauhini et al., Hyderābād, India. In Invest Ophthalmol Vis Sci, Nov 2015
Neuro-retinal cells expressed the neural markers, Map2, β-III tubulin, acetylated tubulin and photoreceptor-specific markers, Crx, rhodopsin, recoverin, calbindin, PKC, NeuroD1, RLBP1, rhodopsin kinase, PDE6A, and PDE6C.
Immunohistochemical Evaluation of Idiopathic Epiretinal Membranes and In Vitro Studies on the Effect of TGF-β on Müller Cells.
Los et al., Groningen, Netherlands. In Invest Ophthalmol Vis Sci, Oct 2015
METHODS: Idiopathic ERM samples from vitrectomy were analyzed for glial acidic fibrillary protein (GFAP), cellular retinaldehyde-binding protein (CRALBP), α-SMA, and type VI collagen using flat-mount immunohistochemistry.
Comparative transcriptomic analysis provides insights into the molecular basis of the metamorphosis and nutrition metabolism change from zoeae to megalopae in Eriocheir sinensis.
Shi et al., Qingdao, China. In Comp Biochem Physiol Part D Genomics Proteomics, Mar 2015
Further, 19 DEGs possibly contributing to the morphological and sensory capability changes of the larvae were identified, like multiple copies of cuticle protein genes, retinaldehyde-binding protein 1 (RLBP1), envelope protein (Envelope) and hormone-related gene ecdysteroid-regulated 16kDa protein (ESR16).
A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation.
Reh et al., Seattle, United States. In Development, Mar 2015
Either treatment leads to a reduction in expression of the Müller glia-specific genes Rlbp1 and Glul, and the failure of many of the Müller glia to repress the bipolar/photoreceptor gene Otx2.
CRALBP supports the mammalian retinal visual cycle and cone vision.
Kefalov et al., In J Clin Invest, Feb 2015
Mutations in the cellular retinaldehyde-binding protein (CRALBP, encoded by RLBP1) can lead to severe cone photoreceptor-mediated vision loss in patients.
Intracellular transport of fat-soluble vitamins A and E.
Arai et al., Tokyo, Japan. In Traffic, 2015
Vitamin A and its derivatives, collectively called retinoids, are solubilized by intracellular retinoid-binding proteins such as cellular retinol-binding protein (CRBP), cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRALBP).
AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice.
Dryja et al., Cambridge, United States. In Mol Ther Methods Clin Dev, 2014
Recessive mutations in RLBP1 cause a form of retinitis pigmentosa in which the retina, before its degeneration leads to blindness, abnormally slowly recovers sensitivity after exposure to light.
Specific tools for targeting and expression in Müller glial cells.
Wijnholds et al., Amsterdam, Netherlands. In Mol Ther Methods Clin Dev, 2013
Retinaldehyde-binding protein 1 (RLBP1) promoter was the most powerful promoter to transduce Müller glial cells.
Clinical features of a Japanese case with Bothnia dystrophy.
Hotta et al., Hamamatsu, Japan. In Ophthalmic Genet, 2012
The clinical characteristics of a Japanese patient with a homozygous R234W mutation in RLBP1 are very similar to that of Swedish patients with Bothnia dystrophy.
Cellular retinaldehyde-binding protein (CRALBP) is a direct downstream target of transcription factor Pax6.
Tarabykin et al., Göttingen, Germany. In Biochim Biophys Acta, 2012
CRALBP is a direct downstream target of Pax6.
Molecular clues to Bothnia-type retinal dystrophy.
Stocker et al., Bern, Switzerland. In Adv Exp Med Biol, 2011
The R234W mutation reveals impaired 11-cis-retinal release through stabilization of the ligand complex.
[Blind spot enlargement syndrome in acute zonal occult outer retinopathy with detection of autoantibodies against the retinal antigens CRALBP and S-Ag].
Lorenz et al., Gießen, Germany. In Ophthalmologe, 2011
Identification of autoantibodies specific for two retinal antigens (CRALBP and S-Ag) supports the concept of an autoimmunological origin of the disease.
Mutations in RLBP1 associated with fundus albipunctatus in consanguineous Pakistani families.
Riazuddin et al., Lahore, Pakistan. In Br J Ophthalmol, 2011
mutations in RLBP1 are responsible for fundus albipunctatus in the affected individuals of these consanguineous Pakistani families.
Ocular immunology in equine recurrent uveitis.
Deeg, München, Germany. In Vet Ophthalmol, 2008
Interphotoreceptor-retinoid binding protein (IRBP) and cellular retinaldehyde-binding protein (CRALBP) are capable to induce ERU-like disease in experimental horses, with the unique possibility to activate relapses in a well-defined manner.
Equine recurrent uveitis--a spontaneous horse model of uveitis.
Ueffing et al., München, Germany. In Ophthalmic Res, 2007
We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome.
Origin of the vertebrate visual cycle.
Tsuda et al., Japan. In Photochem Photobiol, 2007
We identified four genes encoding putative visual cycle proteins, homologs of retinal G protein-coupled receptor (Ci-opsin3), cellular retinaldehyde-binding protein (Ci-CRALBP), beta-carotene 15,15'monooxygenase (Ci-BCO) and RPE-specific 65 kDa protein (Ci-RPE65) in the ascidian, Ciona intestinalis.
Integrative strategies to identify candidate genes in rodent models of human alcoholism.
Treadwell, Ottawa, Canada. In Genome, 2006
In our study, 2 genes, retinaldehyde binding protein 1 (Rlbp1) and syntaxin 12 (Stx12), were found to be strong candidates for ethanol preference.
Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa.
Denton et al., Dunedin, New Zealand. In Nat Genet, 1997
In the current study, molecular genetic analysis of a consanguineous pedigree segregating for non-syndromic autosomal recessive retinitis pigmentosa (arRP) indicated that the affected siblings were homozygous by descent for a G4763A nucleotide substitution in RLBP1, the gene encoding cellular retinaldehyde-binding protein (CRALBP).
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