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Cytoplasmic polyadenylation element binding protein 1

CPEB, CPEB1, CPE-binding protein
This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD36, PCNA, CAN, POLYMERASE, V1a
Papers on CPEB
Block of CDK1-dependent polyadenosine elongation of Cyclin B mRNA in metaphase-i-arrested starfish oocytes is released by intracellular pH elevation upon spawning.
Chiba et al., Tokyo, Japan. In Mol Reprod Dev, Jan 2016
In isolated animal oocytes, translation of maternal mRNAs containing a cytoplasmic polyadenylation element (CPE), such as cyclin B, is activated by in vitro stimulation of meiotic resumption which induces phosphorylation of CPEB (CPE-binding protein) and elongation of their polyadenosine (poly(A)) tails; whether or not this model can be applied in vivo to oocytes arrested at metaphase of meiosis I in ovaries is unknown.
Translational Control of Autophagy by Orb in the Drosophila Germline.
Simonelig et al., Montpellier, France. In Dev Cell, Jan 2016
Drosophila Orb, the homolog of vertebrate CPEB, is a key translational regulator involved in oocyte polarity and maturation through poly(A) tail elongation of specific mRNAs.
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of VEGF and Angiogenesis in Chronic Liver Disease.
Mendez et al., Barcelona, Spain. In Gastroenterology, Dec 2015
In a search for ways to inhibit pathologic production or activities of VEGF without affecting its normal production or functions, we investigated the post-transcriptional regulation of VEGF by the cytoplasmic polyadenylation element-binding proteins CPEB1 and CPEB4 during development of portal hypertension and liver disease.
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Bar-Eli et al., Houston, United States. In Nat Cell Biol, Mar 2015
Indeed, wild-type miR-455-5p promotes melanoma metastasis through inhibition of the tumour suppressor gene CPEB1.
Dendritic targeting of short and long 3' UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins.
Tongiorgi et al., Trieste, Italy. In Front Mol Neurosci, 2014
We found that dendritic localization of BDNF mRNAs with short 3' UTR was induced by depolarization and NT3 in vitro or by seizures in vivo and required CPEB-1, -2 and ELAV-2, -4.
Aquaporin7 plays a crucial role in tolerance to hyperosmotic stress and in the survival of oocytes during cryopreservation.
Huang et al., Shanghai, China. In Sci Rep, 2014
Moreover, we found that hyperosmosis could upregulate the phosphorylation levels of CPE-binding protein (CPEB) and Aurora A. Inhibition of the PI3K and PKC pathways blocked the hyperosmosis-induced upregulation of AQP7 and the phosphorylation of CPEB and Aurora A in oocytes.
Synaptic control of local translation: the plot thickens with new characters.
Boccaccio et al., Buenos Aires, Argentina. In Cell Mol Life Sci, 2014
The RBPs FMRP and CPEB play a well-established role in synaptic translation, and additional regulatory factors are emerging.
Cytoplasmic polyadenylation element binding proteins in development, health, and disease.
Richter et al., Worcester, United States. In Annu Rev Cell Dev Biol, 2013
The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific mRNA binding proteins that control translation in development, health, and disease.
Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology.
Richter et al., Worcester, United States. In Nat Med, 2013
FMRP and cytoplasmic polyadenylation element-binding protein (CPEB), an activator of translation, are present in neuronal dendrites, are predicted to bind many of the same mRNAs and may mediate a translational homeostasis that, when imbalanced, results in FXS.
Specificity factors in cytoplasmic polyadenylation.
de Moor et al., Denver, United States. In Wiley Interdiscip Rev Rna, 2013
In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, αCP2, hnRNP-E2), and Bicaudal C (BICC1).
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Kleene, Boston, United States. In Reproduction, 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Translational control of cell growth and malignancy by the CPEBs.
Richter et al., Worcester, United States. In Nat Rev Cancer, 2013
Several CPEB-regulated mRNAs govern cell cycle progression, regulate senescence, establish cell polarity, and promote tumorigenesis and metastasis.
CPEB1 coordinates alternative 3'-UTR formation with translational regulation.
Méndez et al., Barcelona, Spain. In Nature, 2013
Here we report that the cytoplasmic polyadenylation element binding protein 1 (CPEB1), an RNA-binding protein that regulates mRNA translation, also controls alternative 3'-UTR processing.
Translational control of mitochondrial energy production mediates neuron morphogenesis.
Richter et al., Worcester, United States. In Cell Metab, 2013
Knockout mice lacking the Cytoplasmic Polyadenylation Element Binding protein 1 (CPEB1) have brain-specific dysfunctional mitochondria and reduced ATP levels, which is due to defective polyadenylation-induced translation of electron transport chain complex I protein NDUFV2 mRNA.
CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach.
Seruca et al., Porto, Portugal. In Gut, 2012
The first evidence of CPEB1 involvement in GC is presented, along with the molecular mechanism underlying the regulation of its expression and its potential role in invasion and angiogenesis.
Cytoplasmic RNA-binding proteins and the control of complex brain function.
Richter et al., New York City, United States. In Cold Spring Harb Perspect Biol, 2012
Although translation in the CNS is regulated by multiple mechanisms and factors, we focus this review on regulatory mRNA-binding proteins with particular emphasis on fragile X mental retardation protein (FMRP) and cytoplasmic polyadenylation element binding (CPEB) because they have been shown to be at the nexus of translational control and brain function in health and disease.
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Richter et al., Worcester, United States. In Mol Cell, 2012
poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
Generation of a pain memory in the primary afferent nociceptor triggered by PKCε activation of CPEB.
Levine et al., San Francisco, United States. In J Neurosci, 2012
CPEB is downstream of protein kinase Cepsilon in the cellular signaling cascade responsible for priming the induction of hyperalgesia.
Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance.
Richter et al., Worcester, United States. In Plos Genet, 2012
when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin-resistant.Our results show that Cpeb1 regulated translation is a key process involved in insulin signaling
CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity.
Richter et al., Worcester, United States. In Nat Commun, 2011
CPEB-mediated zonal occludens-1 mRNA localization is essential for tight-junction assembly and mammary epithelial cell polarity
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