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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Carboxypeptidase A5

CPA5, carboxypeptidase A5, carbA
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: carboxypeptidase, ACID, CPA2, CPA4, MAST
Papers on CPA5
Worse outcome of sorafenib therapy associated with ascites and Child-Pugh score in advanced hepatocellular carcinoma.
Kim et al., South Korea. In J Gastroenterol Hepatol, 2013
Disease control rates were significantly higher in CP class A (CPA) than in CP class B (CPB) patients.
The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo.
Berman et al., Halifax, Canada. In Blood, 2012
Colocalization studies demonstrated zebrafish notch receptor expression in cells expressing carboxypeptidase A5 (cpa5), a zebrafish mast cell-specific marker.
Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.
Berman et al., Halifax, Canada. In Dev Comp Immunol, 2011
Whole mount in situ hybridization on 7-day embryos demonstrated co-localization of cpa5, a MC-specific marker, with myd88, a toll-like receptor adaptor, and zebrafish FcɛRI subunit homologs.
Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish.
Sagerström et al., Worcester, United States. In Plos One, 2008
Non-endocrine endodermal gene expression is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp.
Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination.
Berman et al., Halifax, Canada. In Blood, 2008
Carboxypeptidase A5 (cpa5), a mast cell-specific enzyme, is expressed in zebrafish blood cells beginning at 24 hours post fertilization (hpf).
Proteomic analysis of differentially expressed proteins between metastatic and non-metastatic human colorectal carcinoma cell lines.
Yi-Li et al., Xi'an, China. In Eur J Gastroenterol Hepatol, 2005
RESULTS: The protein endothelial cell growth factor 1 (platelet-derived), rhotekin protein (RTKN), septin 1, cyclin-dependent kinase 1, sialic acid binding Ig-like lectin 11, tyrosinase-related protein-2, translin-like protein, and DNA directed RNA polymerase II polypeptide J-related gene isoform 2 appeared in metastatic but were not detected in non-metastatic cell lines, whereas integrin-linked kinase-associated protein phosphatase 2C isoform 2, MHC class I promoter binding protein, protein phosphatase 2A regulatory subunit B' (PR 53), carboxypeptidase A5, paired box transcription factor, zinc finger protein 79, and apolipoprotein B-48 were detected in non-metastatic but were absent in metastatic cell lines.
Molecular characterization of tomato-infecting begomoviruses in Thailand.
Attathom et al., Nakhon Pathom, Thailand. In Virus Res, 2005
Bipartite geminiviruses infecting tomatoes in Thailand were detected by polymerase chain reaction (PCR) using CPA5/CPA2 primers.
Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.
Kishino et al., Sapporo, Japan. In Genomics, 2004
The imprinting status of two (TSGA13 and CPA5) was not conclusive, because of their weak and/or tissue-specific expression and inconstant results.
Neuropeptide-processing carboxypeptidases.
Fricker et al., United States. In Life Sci, 2003
To test whether CPA-5 protein has a distribution pattern in pituitary that is consistent with a role for this enzyme in the non-basic processing of proopiomelanocortin-derived peptides such as beta-endorphin and adrenocorticotropin, we examined the distribution of CPA-5 using immunocytochemistry.
The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.
Moore et al., London, United Kingdom. In J Med Genet, 2003
One hundred kilobases proximal to MEST lies a group of four carboxypeptidase A (CPA) genes.
Higher testosterone dose impairs sperm suppression induced by a combined androgen-progestin regimen.
Morselli-Labate et al., Bologna, Italy. In J Androl, 2002
Eighteen men aged 21-45 were treated with CPA 5 mg/day and with TE 100 mg/week (n = 9; CPA-5-100) or TE 200 mg/week (n = 9; CPA-5-200) for 16 weeks.
Identification and characterization of three members of the human metallocarboxypeptidase gene family.
Fricker et al., New York City, United States. In J Biol Chem, 2002
Pro-CPA5 was not enzymatically active toward standard CPA substrates, but after incubation with prohormone convertase 4 the resulting protein was able to cleave furylacryloyl-Gly-Leu, with 3-4-fold greater activity at pH 7.4 than at 5.6.
Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.
International Molecular Genetic Study of Autism Consortium (IMGSAC) et al., Oxford, United Kingdom. In Mol Psychiatry, 2001
mutation screening and imprinting analysis of candidate genes for autism in the 7q12 region.
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