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Carboxypeptidase A4

CPA4, carboxypeptidase A4, CPA3
This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: carboxypeptidase, MAST, CAN, chymase, HAD
Papers on CPA4
Dietary treatment modulates mast cell phenotype, density, and activity in adult eosinophilic oesophagitis.
Vicario et al., Alcázar de San Juan, Spain. In Clin Exp Allergy, Jan 2016
Gene and protein expression of specific MC proteases (CPA3, CMA, and TPSB2) were evaluated with qPCR and immunofluorescence.
Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma.
Gibson et al., Newcastle, Australia. In Eur Respir J, Jan 2016
Sputum mast cell subtypes were determined by molecular phenotyping based on expression of mast cell biomarkers (tryptase (TPSAB1), chymase (CMA1) and carboxypeptidase A3 (CPA3)).
Increased asthma and adipose tissue inflammatory gene expression with obesity and Inuit migration to a western country.
Gibson et al., Copenhagen, Denmark. In Respir Med, Jan 2016
Adipose tissue biopsies were homogenised, RNA extracted, and PCR was performed to determine the relative gene expression of mast cell (tryptase, chymase, CPA3) and inflammatory markers (IL-6, IL-1β, and CD163).
Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.
Backer et al., Copenhagen, Denmark. In Clin Exp Allergy, Sep 2015
Increased submucosal MCTC numbers were associated with increased levels of mRNA for TSLP and CPA3 in asthmatics.
[Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media].
Gao et al., In Fa Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.
Bricca et al., Beirut, Lebanon. In J Hypertens, Jun 2015
Two of them (M1 and M2) contained genes coding for angiotensin metabolizing enzymes involved in different pathways: M1 included ACE, MME, RNPEP, and DPP3, in addition to 7 other genes; and M2 included CMA1, CTSG, and CPA3.
An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases.
Iyer et al., Singapore, Singapore. In Oral Oncol, Apr 2015
RESULTS: We identified an 11 gene signature (GGH, MTFR1, CDKN3, PSRC1, SMIM3, CA9, IRX4, CPA3, ZSCAN16, CBX7 and ZFP3) which was robust in segregating tumors by ECS status.
Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.
Rothenberg et al., Chapel Hill, United States. In J Allergy Clin Immunol, 2015
Bioinformatics analysis revealed largely overlapping transcriptomes between patients with PPI-REE and those with EoE, including the genes for eosinophil chemotaxis (eotaxin 3, CCL26), barrier molecules (desmoglein 1, DSG1), tissue remodeling (periostin, POSTN), and mast cells (carboxypeptidase A, CPA3).
Interaction between Common Genetic Variants and Total Fat Intake on Low-Density Lipoprotein Peak Particle Diameter: A Genome-Wide Association Study.
Vohl et al., Québec, Canada. In J Nutrigenet Nutrigenomics, 2014
RESULTS: The GWAS analyses 29 identified independent SNP × total fat intake interaction effects on the LDL-PPD at p < 10(-5), including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4.
Revealing Glycoproteins in the Secretome of MCF-7 Human Breast Cancer Cells.
Chen et al., George Town, Malaysia. In Biomed Res Int, 2014
Carboxypeptidase A4 (CPA4), alpha-1-antitrypsin (AAT), haptoglobin (HP), and HSC70 were detected in the medium of MCF-7, while only CPA4 and osteonectin (ON) were detected in HMEpC medium.
Cell Pluripotency Levels Associated with Imprinted Genes in Human.
Ding et al., Shanghai, China. In Comput Math Methods Med, 2014
A new CPA4-KLF14 region which locates in chromosomal homologous segments (CHSs) within mammals and include both imprinted genes and significantly expressed miRNAs was first identified.
Pivotal role of mast cell carboxypeptidase A in mediating protection against small intestinal ischemia-reperfusion injury in rats after ischemic preconditioning.
Gan et al., Guangzhou, China. In J Surg Res, 2014
At the end of experiment, intestine tissue was obtained for assays of the MC-CPA3, tumor necrosis factor-α, interleukin-6, and ET-1 contents and myeloperoxidase activities.
[Expression profile of genes associated with the histaminergic system estimated by oligonucleotide microarray analysis HG-U133A in women with endometrial adenocarcinoma].
Mazurek et al., In Ginekol Pol, 2014
Further analysis led to the identification of differentially expressed genes in grades G1, G2 and G3 of endometrial adenocarcinoma as compared to the control group, which were specific for each of the studied groups in grade G1 (CPA3), in grade G2 (HNMT LYN, DPT ITPKB, RASA4, APR RAB1 1FIP1, YWHAZ, VAMP8, RAB25) and in grade G3 (HRH3).
Changes in free polyamine levels, expression of polyamine biosynthesis genes, and performance of rice cultivars under salt stress: a comparison with responses to drought.
Zuther et al., Potsdam, Germany. In Front Plant Sci, 2013
Based on expression profiles, investigated genes were divided into generally stress-induced genes (ADC2, SPD/SPM2, SPD/SPM3), one generally stress-repressed gene (ADC1), constitutively expressed genes (CPA1, CPA2, CPA4, SAMDC1, SPD/SPM1), specifically drought-induced genes (SAMDC2, AIH), one specifically drought-repressed gene (CPA3) and one specifically salt-stress repressed gene (SAMDC4), revealing both overlapping and specific stress responses under these conditions.
Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4.
Reverter et al., Barcelona, Spain. In J Biol Chem, 2012
NvCL form Nerita versicolor is a tight-binding inhibitor that interacts with the active site of the CPA4 in a substrate-like manner.
Complementary positional proteomics for screening substrates of endo- and exoproteases.
Gevaert et al., Gent, Belgium. In Nat Methods, 2010
We describe a positional proteomics approach to simultaneously analyze N- and C-terminal peptides and used it to screen for human protein substrates of granzyme B and carboxypeptidase A4 in human cell lysates.
Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.
Fricker et al., Barcelona, Spain. In J Biol Chem, 2010
CPA4 functions in neuropeptide processing and regulation in the extracellular environment
Carboxypeptidase 4 gene variants and early-onset intermediate-to-high risk prostate cancer.
Witte et al., San Francisco, United States. In Bmc Cancer, 2008
genetic polymorphism is associated with an increased risk of aggressive prostate cancer among younger patients (< 66 years)
Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin.
Gomis-Rütha et al., Barcelona, Spain. In Cell Mol Life Sci, 2005
The three-dimensional structure of procarboxypeptidase-A4 (hPCPA4) has been solved and shows the features of related metallocarboxypeptidase zymogens, with a preformed alpha/beta/-hydrolase active-enzyme moiety (hCPA4) and an inhibiting pro-domain (PD).
The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain.
Kishino et al., Nagasaki, Japan. In Hum Genet, 2003
CPA4 gene is imprinted, with preferential expression from the maternal allele in many fetal tissues, but not in fetal brain.
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