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Carboxypeptidase A2

CPA2, carboxypeptidase A2
Three different forms of human pancreatic procarboxypeptidase A have been isolated. The encoded protein represents the A2 form, which is a monomeric protein with different biochemical properties from the A1 and A3 forms. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues and is a secreted protein. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: ACID, carboxypeptidase, HAD, CAN, CPA4
Papers on CPA2
(E)-2-Cyano-3-(substituted phenyl)acrylamide analogs as potent inhibitors of tyrosinase: A linear β-phenyl-α,β-unsaturated carbonyl scaffold.
Moon et al., Pusan, South Korea. In Bioorg Med Chem, Jan 2016
Results from the docking simulation indicated that CPA2 could bind directly to the active site of mushroom tyrosinase and the binding affinity of CPA2 for tyrosinase might be higher than that of kojic acid, a well-known potent tyrosinase inhibitor.
Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.
Witt et al., Sendai, Japan. In Am J Physiol Gastrointest Liver Physiol, Nov 2015
Besides CPA1, there are two other human pancreatic carboxypeptidases (CPA2 and CPB1).
Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities.
Dow et al., Glasgow, United Kingdom. In Proc Natl Acad Sci U S A, Oct 2015
Under salt stress, knockdown of either gene decreases survival, demonstrating a key role for the CPA2 family in ion homeostasis.
Functional and structural dynamics of NhaA, a prototype for Na(+) and H(+) antiporters, which are responsible for Na(+) and H(+) homeostasis in cells.
Padan, Jerusalem, Israel. In Biochim Biophys Acta, 2014
Ultimately, integrative results will shed light on the mechanism of activity and pH regulation of NhaA, a prototype of the CPA2 family of transporters.
Changes in free polyamine levels, expression of polyamine biosynthesis genes, and performance of rice cultivars under salt stress: a comparison with responses to drought.
Zuther et al., Potsdam, Germany. In Front Plant Sci, 2013
Based on expression profiles, investigated genes were divided into generally stress-induced genes (ADC2, SPD/SPM2, SPD/SPM3), one generally stress-repressed gene (ADC1), constitutively expressed genes (CPA1, CPA2, CPA4, SAMDC1, SPD/SPM1), specifically drought-induced genes (SAMDC2, AIH), one specifically drought-repressed gene (CPA3) and one specifically salt-stress repressed gene (SAMDC4), revealing both overlapping and specific stress responses under these conditions.
A Ham1p-dependent mechanism and modulation of the pyrimidine biosynthetic pathway can both confer resistance to 5-fluorouracil in yeast.
Ronne et al., Uppsala, Sweden. In Plos One, 2012
We cloned five genes: CPA1, CPA2, HMS1, HAM1 and YJL055W.
Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides.
Oliveira et al., Ribeirão Preto, Brazil. In Peptides, 2012
gene transcripts for CPA2 in mesentery and other extrapancreatic tissues indicate that CPA2 might play a role in the renin-angiotensin system in addition to it'sfunction as digestive enzyme
Conserved and diversified gene families of monovalent cation/h(+) antiporters from algae to flowering plants.
Sze et al., College Park, United States. In Front Plant Sci, 2011
Many CPA1 genes from bacteria, fungi, metazoa, and plants have been functionally characterized; though roles of plant CPA2 genes encoding K(+)-efflux antiporter (KEA) and cation/H(+) exchanger (CHX) families are largely unknown.
Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans.
Heitman et al., Durham, United States. In Plos Genet, 2011
Multiple copies of the cpa1::ADE2 transgene were ectopically integrated into the genome, leading to silencing of the endogenous CPA1 and CPA2 genes encoding the cyclosporine A target protein cyclophilin A. Given that CPA1-derived antisense siRNAs were detected in the silenced isolates, and that RNAi components (Rdp1, Ago1, and Dcr2) are required for silencing, we hypothesize that an RNAi pathway is involved, in which siRNAs function as trans factors to silence both the CPA1 and the CPA2 genes.
Relating organic fouling of reverse osmosis membranes to adsorption during the reclamation of secondary effluents containing methylene blue and rhodamine B.
Hou et al., Wuhan, China. In J Hazard Mater, 2011
The characteristic fouling kinetics was accounted by Langmuir-Hinshelwood (L-H) kinetics model for initial fouling, with the fouling rate constant k=0.0556μm s(-1)min(-1) and k=0.0181μm s(-1)min(-1) for MB and RB fouling RO membrane CPA2, respectively.
Reverse transcription polymerase chain reaction (RT-PCR) analysis of proteolytic enzymes in cultures of human respiratory epithelial cells.
Ehrhardt et al., Dublin, Ireland. In J Aerosol Med Pulm Drug Deliv, 2011
METHODS: The mRNA expression of proteolytic enzymes (i.e., carboxypeptidases: CPA1, CPA2, CPB, CPM; gamma-glutamyltransferases: GGT1, GGT2; angiotensin-converting enzymes: ACE, ACE2; aminopeptidases: APA, APB, APN, APP1, APP2, APP3; endopeptidases: 24.11 (neprilysin), 24.15 (thimet oligopeptidase), 24.18 (meprin A); enteropeptidase; trypsin 1, trypsin 2; neutrophilic elastase; dipeptidyl peptidase 4; gamma-glutamylhydrolase) was investigated by semiquantitative RT-PCR in human bronchial (hBEpC, Calu-3, 16HBE14o-) and alveolar (A549) epithelial cells, respectively.
Detection of differential proteomes associated with the development of type 2 diabetes in the Zucker rat model using the iTRAQ technique.
Kim et al., Seoul, South Korea. In J Proteome Res, 2011
Notably, the novel proteins involved in impaired insulin secretion (Scg2, Anxa2, and Rab10), mitochondrial dysfunction (Atp5b and Atp5l), extracellular matrix proteins (Lgal-1, Vim, and Fbn1), and microvascular ischemia (CPA1, CPA2, CPB, Cela2a, and Cela3b) were observed for the first time.
Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
Sahin-Tóth et al., Boston, United States. In J Biol Chem, 2011
Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.
Villegas et al., Barcelona, Spain. In Biochemistry, 2009
we have used one of the best-characterized models for folding and misfolding, the activation domain of procarboxypeptidase A2. The wild type (WT) and three mutants affecting the kinetics of aggregation have been studied by IR from the folded state
High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.
Baker et al., Seattle, United States. In J Mol Biol, 2007
The high-resolution crystal structure and solution NMR structure of AYEdesign show that the experimentally determined backbone and side-chains conformations are effectively superimposable with the computational model at atomic resolution.
Evolutionary origins of eukaryotic sodium/proton exchangers.
Rao et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2005
This analysis initially required examining the entire monovalent cation proton antiporter (CPA) superfamily that includes the CPA1, CPA2, and NaT-DC families of transporters, each of which has a unique set of bacterial ancestors.
NMR solution structure of the activation domain of human procarboxypeptidase A2.
Rico et al., Madrid, Spain. In Protein Sci, 2003
NMR structure of the activation domain
Genetic mapping of arg, cpa, car and tsm genes in Saccharomyces cerevisiae by trisomic analysis.
Mortimer et al., Gembloux, Belgium. In Curr Genet, 1982
By use of a set of 8 aneuploid strains of the yeast Saccharomyces cerevisiae, carrying from 1 to 5 identified disomic chromosomes, in crosses to a set of haploid strains collectively bearing 11 unmapped genes, the following chromosome assignments were obtained for these unmapped genes: arg80 on XIII;arg3 on X;car2 on XII; cpa1 and tsm8740 on XV; tsm7269 (=rna6) on II; cpa2 on X or XV; arg82 and tsm4572 on III, IV or XVI; car1 and arg81 on II, IV, VI, VII or XVI.
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