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Cytochrome c oxidase subunit VIc

COX6C, cytochrome c oxidase subunit VIc
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, POLYMERASE, COX4
Papers on COX6C
Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation.
Nijland et al., Coimbra, Portugal. In Am J Physiol Renal Physiol, Jul 2015
The alteration in mRNA levels was accompanied by a decrease in mitochondrial protein cytochrome c oxidase subunit VIc.
[Relation between Injury Time and the Expression of COX6C mRNA in Skeletal Muscle of Rats after Contusion].
Wang et al., In Fa Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To investigate the relation between injury time and the expression of cytochrome c oxidase subunit VIc (COX6C) mRNA in skeletal muscle of rat after contusion.
Lung epithelial cells resist influenza A infection by inducing the expression of cytochrome c oxidase VIc which is modulated by miRNA 4276.
Beezhold et al., Morgantown, United States. In Virology, 2014
Within the first 3h of infection with influenza virus, significant down-regulation of hsa-miRNA-4276 (miRNA-4276) is followed by a 2-fold increase in cytochrome c oxidase VIC (COX6C) mRNA was found to occur in human alveolar and bronchial epithelial cells.
Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway.
Dalloul et al., Nancy, France. In Leuk Lymphoma, 2013
Using a B-cell differentiation model and mRNA profiling, we found that recombinant (r)IL-24 stimulated genes of the mitochondrial apoptotic pathway (Bax, Bid, Casp8, COX6C, COX7B) after 36 h, whereas the transcription of genes involved in DNA replication and metabolism was inhibited within 6 h.
Low-intensity laser irradiation at 660 nm stimulates transcription of genes involved in the electron transport chain.
Abrahamse et al., Johannesburg, South Africa. In Photomed Laser Surg, 2013
RESULTS: LILI upregulated cytochrome c oxidase subunit VIb polypeptide 2 (COX6B2), cytochrome c oxidase subunit VIc (COX6C), and pyrophosphatase (inorganic) 1 (PPA1) in diabetic wounded cells; COX6C, ATP synthase, H+transporting, mitochondrial Fo complex, subunit B1 (ATP5F1), nicotinamide adenine dinucleotide (NADH) dehydrogenase (ubiquinone) 1 alpha subcomplex, 11 (NDUFA11), and NADH dehydrogenase (ubiquinone) Fe-S protein 7 (NDUFS7) in wounded cells; and ATPase, H+/K+ exchanging, beta polypeptide (ATP4B), and ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) (ATP5G2) in ischemic cells.
Downregulation of nuclear-encoded genes of oxidative metabolism in dialyzed chronic kidney disease patients.
Lupo et al., Verona, Italy. In Plos One, 2012
Additionally, mRNA levels of several PGC1-α downstream target genes (TFAM, COX6C,COX7C, UQCRH and MCAD) were profoundly down-regulated in PD cells.
Gene expression profiling in glomeruli of diabetic nephropathy rat.
Xiang et al., Beijing, China. In Exp Biol Med (maywood), 2012
Q-RT-PCR verified that Atp5b (F1-ATPase beta subunit), Col1a1 (collagen type 1 alpha 1), Cox6c (cytochrome c oxidase subunit VIc), Ndufs3 (NADH dehydrogenase [ubiquinone] Fe-S protein 3) and Tgfb1 (transforming growth factor β1) were significantly up-regulated in the DN group.
Telmisartan improves kidney function through inhibition of the oxidative phosphorylation pathway in diabetic rats.
Xiang et al., Beijing, China. In J Mol Endocrinol, 2012
Quantitative real-time PCR verified that the H+ transporting mitochondrial F1 complex, beta subunit (Atp5b), cytochrome c oxidase subunit VIc (Cox6c), and NADH dehydrogenase (ubiquinone) Fe-S protein 3 (Ndufs3) were significantly downregulated both in TeL and TeH groups, while nephrosis 1 homolog (Nphs1) and nephrosis 2 homolog (Nphs2) were significantly upregulated.
Development of single blastomeres derived from two-cell embryos produced in vitro in pigs.
Nagai et al., Tsukuba, Japan. In Theriogenology, 2011
However, there was no significant difference among groups for expression of transcripts associated with responses to stress (HSPE1, HSPD1, and HSPCA) or glucose catabolism (ENO1, COX6C, COX7B, NDUFA4, NDUFA13, UCRC, and UQCRFS1) in blastocysts.
Coordination of cytochrome c oxidase gene expression in the remodelling of skeletal muscle.
Moyes et al., Kingston, Canada. In J Exp Biol, 2011
Though zebrafish COX activity did not change in the cold, the transcript levels of four subunits decreased significantly (COX5A1, 60% decrease; COX6A2, 70% decrease; COX6C, 50% decrease; COX7B, 55% decrease).
Polymorphic variation in cytochrome oxidase subunit genes.
Swerdlow et al., Kansas City, United States. In J Alzheimers Dis, 2009
Frequent untranslated region (UTR) polymorphisms were seen in COX6A1, COX6B1, COX6C, and COX7A1; heterogeneity in a COX7A1 5' UTR Sp1 site was extensive.
Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD.
Gayan-Ramirez et al., Leuven, Belgium. In Cell Physiol Biochem, 2009
Real Time PCR data confirmed 1) increased expression of MuRF1 and MAFbx, markers of the ubiquitin dependent catabolism pathway, and 2) decreased expression levels of COX6C, a marker of mitochondrial respiration.
Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria.
McKenzie et al., Melbourne, Australia. In Febs J, 2009
Data found that subunits Cox6a, Cox6b and Cox7a assembled into pre-existing complex IV, while Cox4-1 and Cox6c subunits assembled into subcomplexes that may represent rate-limiting intermediates.
Quantitative assessment of tissue biomarkers and construction of a model to predict outcome in breast cancer using multiple imputation.
Tuck et al., New Haven, United States. In Cancer Inform, 2008
The best model is obtained by including both protein markers (including COX6C, GATA3, NAT1, and ESR1) and lymph node status.
Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells.
Luparello et al., Palermo, Italy. In Biol Chem, 2007
The results obtained provide first evidence that PTHrP(38-94) amide can affect gene expression in tumor cells, identifying A4-differentiation protein/PLP2 as up-regulated, and HOX7/MSX1, COX6C, FZD6, OXR1 and TMCO4 as down-regulated genes in treated cells, and suggest that the cytotoxic activity of the peptide can be ascribed, at least in part, to such transcriptional reprogramming.
Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis.
Higuchi et al., Nagasaki, Japan. In Mamm Genome, 2007
We observed that the expression of three genes related to cell proliferation (myosin regulatory light chain B, aldolase 1A isoform, and cytochrome c oxidase subunit VIc) were upregulated and four genes implicated in spermatogenesis were downregulated in SAMP1 mice.
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