The Cosmc connection to the Tn antigen in cancer.
Atlanta, United States. In Cancer Biomark, 2014
Formation of the active form of the T-synthase requires a unique molecular chaperone termed Cosmc, encoded by Cosmc on the X-chromosome (Xq24 in humans, Xc3 in mice).
Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers.
Atlanta, United States. In Proteomics Clin Appl, 2013
The major pathological mechanism for expression of the Tn and STn antigens is compromised T-synthase activity, resulting from alteration of the X-linked gene that encodes for Cosmc, a molecular chaperone specifically required for the correct folding of T-synthase to form active enzyme.
Abnormalities of glycogenes in tonsillar lymphocytes in IgA nephropathy.
Okayama, Japan. In Adv Otorhinolaryngol, 2010
Gene expression of β1,3-galactosyltransferase (β3GalT), Cosmc, UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyl-transferase 2, were significantly down regulated in tonsillar CD19-positive B lymphocytes from IgAN patients compared to control as determined by real-time RT-PCR.
Protein glycosylation: chaperone mutation in Tn syndrome.
Oklahoma City, United States. In Nature, 2005
Tn syndrome is associated with a somatic mutation in Cosmc, a gene on the X chromosome that encodes a molecular 'chaperone' that is required for the proper folding and hence full activity of T-synthase