The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.
Montevideo, Uruguay. In Cell Mol Life Sci, 2014
To explain these facts and other experimental data, we present here a model for the assembly of the neuroexocytosis apparatus in which Synaptotagmin and Complexin first assist the zippering of the SNARE complex, and then stabilize and clamp an octameric radial assembly of the SNARE complexes.
Complexin cross-links prefusion SNAREs into a zigzag array.
New Haven, United States. In Nat Struct Mol Biol, 2011
The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion.