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proteins. Page last changed on 19 Dec 2016.
Complement factor H
Complement Factor H, factor H, CFH
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011] (from
NCBI)
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Top mentioned proteins:
AGE, CAN, HAD, ARMS2, V1a
Papers using
Complement Factor H
antibodies
Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine
Supplier
In Scientific Reports, 2006
... Enhanced bacteremia in human factor H transgenic rats infected by ...
Papers on
Complement Factor H
Cell-free hemoglobin: a novel mediator of acute lung injury.
New
United States. In Am J Physiol Lung Cell Mol Physiol, Feb 2016
UNASSIGNED: Patients with the acute respiratory distress syndrome (ARDS) have elevated levels of cell-free hemoglobin (CFH) in the airspace, but the contribution of CFH to the pathogenesis of acute lung injury is unknown.
Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes.
New
Lund, Sweden. In Cell Death Differ, Feb 2016
UNASSIGNED: Factor H (FH) binds apoptotic cells to limit the inflammatory potential of complement.
Photodynamic therapy in VEGF inhibition non-responders-pharmacogenetic study in age-related macular degeneration assessed with swept-source optical coherence tomography.
New
Katowice, Poland. In Photodiagnosis Photodyn Ther, Feb 2016
Greatest linear dimension (GLD) of the lesion, best corrected visual acuity (BCVA), central subfield macular thickness (CSMT) and central choroidal thickness were assessed and compared between CFH and ARMS2 genotype groups.
A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
New
Örebro, Sweden. In J Immunol, Feb 2016
Many pathogens, including N. gonorrhoeae, bind the complement inhibitor factor H (FH) to evade complement-dependent killing.
Successful treatment of neonatal atypical hemolytic uremic syndrome with C5 monoclonal antibody.
New
Genève, Switzerland. In Arch Pediatr, Feb 2016
UNASSIGNED: Hemolytic uremic syndrome (HUS) is rare in neonates.
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
New
Impact
Ann Arbor, United States. In Nat Genet, Jan 2016
Very rare coding variants (frequency <0.1%) in CFH, CFI and TIMP3 suggest causal roles for these genes, as does a splice variant in SLC16A8.
Age-related macular degeneration: Complement in action.
Review
New
San Francisco, United States. In Immunobiology, Jan 2016
Polymorphisms in genes encoding two important negative regulators of the alternative complement pathway, complement factor H (CFH) and complement factor I (CFI), are associated with the risk for Age-Related Macular Degeneration (AMD), a leading cause of vision impairment in the ageing population.
Association of Two Polymorphisms, rs1061170 and rs1410996, in Complement Factor H with Age-Related Macular Degeneration in an Asian Population: A Meta-Analysis.
Review
New
Chongqing, China. In Ophthalmic Res, Dec 2015
BACKGROUND: With the increasing number of studies indicating that two single-nucleotide polymorphisms (SNPs), rs1061170 and rs1410996, in complement factor H (CFH) might be associated with the susceptibility to age-related macular degeneration (AMD), the exact association still remains uncertain.
Complement factor H in its alternative identity as adrenomedullin-binding protein 1.
Review
New
Oxford, United Kingdom. In Mol Immunol, Nov 2015
Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established.
[The genetic variability of complement system in pathogenesis of age-related macular degeneration].
Review
In Klin Oczna, 2014
Recently, variants in several genes, such as complement H (CFH), complement factor B (CFB), complement 2 (C2), and complement 3 (C3), encoding complement pathway proteins, have been identified as associated with age-related macular degeneration.
Prophylactic Eculizumab Use in Kidney Transplantation: A Review of the Literature and Report of a Case with Atypical Hemolytic Uremic Syndrome.
Review
İstanbul, Turkey. In Ann Transplant, 2014
Our diagnosis was aHUS due to initial results, normal level of ADAMTS activity, and lack of predisposing factors seen in typical HUS.
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
Impact
Boston, United States. In Nat Genet, 2013
Finally, we show that the allele of C3 encoding Gln155 results in resistance to proteolytic inactivation by CFH and CFI.
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
Impact
Ann Arbor, United States. In Nat Genet, 2013
The variants suggest decreased inhibition of C3 by complement factor H, resulting in increased activation of the alternative complement pathway, as a key component of disease biology.
A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration.
Impact
Reykjavík, Iceland. In Nat Genet, 2013
In vitro studies have suggested that the p.Lys155Gln substitution reduces C3b binding to complement factor H, potentially creating resistance to inhibition by this factor.
Temperature triggers immune evasion by Neisseria meningitidis.
Impact
Oxford, United Kingdom. In Nature, 2013
We have identified three independent RNA thermosensors located in the 5' untranslated regions of genes necessary for capsule biosynthesis, the expression of factor H binding protein, and sialylation of lipopolysaccharide, which are essential for meningococcal resistance against immune killing.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.
GeneRIF
Chengdu, China. In Proc Natl Acad Sci U S A, 2012
CFH influences age-related macular degeneration risk by modulating oxidative stress, inflammation, and abnormal angiogenesis
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.
GeneRIF
Jena, Germany. In J Immunol, 2012
we show that native factor H, factor H-like protein 1, and factor H-related protein 1 (CFHR1) bind to PTX3
Choroidal thickness, vascular hyperpermeability, and complement factor H in age-related macular degeneration and polypoidal choroidal vasculopathy.
GeneRIF
Kyoto, Japan. In Invest Ophthalmol Vis Sci, 2012
Choroidal thickness is related to the AMD subtypes, choroidal hyperpermeability, and I62V CFH gene polymorphism.
The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection.
Review
GeneRIF
North Bay Shore, United States. In Biol Chem, 2012
role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection
