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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Complement component 3

Complement C3, C-3, Complement C3b, Complement C3a
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, fibrillin-1, IgM
Papers using Complement C3 antibodies
A method for DNA template preparation using a single embryo.
Fugmann Sebastian D., In PLoS ONE, 2004
... Tryptic soy broth (TSB) was procured from OXOID (UK), and complement C3 and Bf standards were from ADL (USA), rabbit anti-human C3 antibody from Abcam (UK), goat anti-human Bf ...
CLAMP: a biosensor kinetic data analysis program
Stover Cordula M., In PLoS ONE, 1997
... PE anti-human complement C3 monoclonal antibody was purchased from Cedarlane laboratories ...
Papers on Complement C3
Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.
Zheng et al., Houston, United States. In J Neurosci, Feb 2016
Previously, we identified a neuron-glia signaling pathway whereby Aβ acts as an upstream activator of astroglial nuclear factor kappa B (NF-κB), leading to the release of complement C3, which acts on the neuronal C3a receptor (C3aR) to influence dendritic morphology and cognitive function.
CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation.
Matsubara et al., Vancouver, Canada. In Br J Ophthalmol, Feb 2016
METHODS: Postmortem donor eyes were genotyped for the CFH Y402H polymorphism and assessed for complement C3a, C5a, interleukin (IL)-18 and tumour necrosis factor (TNF)-α.
Immune responses to Aeromonas hydrophila infection in Schizothorax prenanti fed with oxidized konjac glucomannan and its acidolysis products.
Feng et al., China. In Fish Shellfish Immunol, Jan 2016
The results showed that the serum lysozyme activity and complement C3 level of fish fed 8.0 g kg(-1) L-OKGM was significantly increased after bacterial infection.
Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1.
D'Cruz et al., London, United Kingdom. In Arthritis Res Ther, Dec 2015
RESULTS: By adjusting for the baseline level (at the first visit), delta soluble vascular cell adhesion molecule-1 (sVCAM-1) showed stronger correlation with changes in ECLAM score and improved sensitivity and specificity for identifying SLE responders versus non-responders compared to conventional SLE biomarkers including anti-dsDNA antibody titre and complement C3.
Supporting evidences for potential biomarkers of endometriosis detected in peripheral blood.
Baldi et al., Roma, Italy. In Data Brief, Dec 2015
In this article we describe the potential value as diagnostic markers for endometriosis of two proteins (serum albumin and complement C3 precursor), previously identified as differentially expressed in women with endometriosis respect to healthy control by 2D gel analysis.
Search for Biomarkers of Intracranial Aneurysms: A Systematic Review.
Elhammady et al., Miami, United States. In World Neurosurg, Nov 2015
IAs are associated with an increase in levels of immunologic markers, particularly complement C3 and C9, immunoglobulins IgG and IgM, M1/M2 macrophages, monocytes, and B and T lymphocytes; increase in blood and CSF levels of adhesion molecules; selectins found on vascular endothelium, platelets, and leukocytes; doubled ratios of elastase-to-alpha-1-antitrypsin as controls; elevated levels of neurofilament heavy chain SM135 and S-100 post rupture; and locus 19q13 with many candidate genes.
Future perspectives in target-specific immunotherapies of myasthenia gravis.
Dalakas, Philadelphia, United States. In Ther Adv Neurol Disord, Nov 2015
Novel biological agents currently on the market, directed against the following molecular pathways, are relevant and specific therapeutic targets that can be tested in MG: (a) T cell intracellular signaling molecules, such as anti-CD52, anti-interleukin (IL) 2 receptors, anti- costimulatory molecules, and anti-Janus tyrosine kinases (JAK1, JAK3) that block the intracellular cascade associated with T-cell activation; (b) B cells and their trophic factors, directed against key B-cell molecules; (c) complement C3 or C5, intercepting the destructive effect of complement-fixing antibodies; (d) cytokines and cytokine receptors, such as those targeting IL-6 which promotes antibody production and IL-17, or the p40 subunit of IL-12/1L-23 that affect regulatory T cells; and (e) T and B cell transmigration molecules associated with lymphocyte egress from the lymphoid organs.
A review of the immune molecules in the sea cucumber.
Liu et al., Dalian, China. In Fish Shellfish Immunol, May 2015
These genes include lectins, antimicrobial peptides, lysozyme, enzymes, clotting protein, pattern recognition proteins, Toll receptors, complement C3 and other humoral factors that might participate in the innate immune system of sea cucumbers.
Inhibition of complement C3 and fibrinogen interaction: a potential novel therapeutic target to reduce cardiovascular disease in diabetes.
Ajjan et al., Leeds, United Kingdom. In Lancet, Mar 2015
BACKGROUND: Enhanced complement C3 incorporation into the fibrin network in diabetes is one mechanism for impaired fibrinolysis and increased thrombosis risk in this condition.
Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.
Inohara et al., Ann Arbor, United States. In Immunity, 2014
Mechanistically, IL-22 augmented bacterial phagocytosis by increasing the expression and bacterial binding of complement C3.
Intracellular sensing of complement C3 activates cell autonomous immunity.
James et al., Cambridge, United Kingdom. In Science, 2014
We found that during this transition, pathogens carried covalently attached complement C3 into the cell, triggering immediate signaling and effector responses.
[Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?].
Wen et al., In Bing Du Xue Bao, 2014
Three models have been proposed, including: (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion.
On the Functional Overlap between Complement and Anti-Microbial Peptides.
Stover et al., Heidelberg, Germany. In Front Immunol, 2013
In search of the origin of complement, a functional homolog of complement C3 involved in opsonization has been identified in horseshoe crabs.
Reduced removal of synaptic terminals from axotomized spinal motoneurons in the absence of complement C3.
Cullheim et al., Stockholm, Sweden. In Exp Neurol, 2012
A non-classical pathway of C3 activation is involved in axotomy-induced adult mice synapse removal, and its inhibition promotes functional recovery.
Relative contributions of dectin-1 and complement to immune responses to particulate β-glucans.
Levitz et al., Worcester, United States. In J Immunol, 2012
Significantly reduced uptake of beta-glucan particles by peritoneal monocytes/ macrophages is observed in C3-deficient mice.
Complementemia and obstetric outcome in pregnancy with antiphospholipid syndrome.
Martino et al., Roma, Italy. In Lupus, 2012
poor pregnancy outcome confirmed among primary antiphospholipid syndrome pregnancies with hypocomplementemia
Prepregnancy obesity and complement system activation in early pregnancy and the subsequent development of preeclampsia.
Holers et al., Aurora, United States. In Am J Obstet Gynecol, 2012
Women who were obese with levels of Bb or C3a in the top quartile were 10.0 (95% confidence interval, 3.3-30) and 8.8 (95% confidence interval, 3-24) times, respectively, more likely to develop preeclampsia compared with the referent group.
Human T cell derived, cell-bound complement iC3b is integrally involved in T cell activation.
Erdei et al., Budapest, Hungary. In Immunol Lett, 2012
demonstrate that the T cell membrane bound iC3b binds to the CR3 and probably to CR4 receptors expressed on monocyte-derived dendritic cells
A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3.
Busch et al., München, Germany. In Nat Immunol, 2011
We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3.
Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.
Christophides et al., London, United Kingdom. In Science, 2009
The complex interacts with the complement C3-like protein, TEP1, promoting its cleavage or stabilization and its subsequent localization on the surface of midgut-invading Plasmodium berghei parasites, targeting them for destruction.
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