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Complement component 2

Complement C2, co-2
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, SIMPLE
Papers on Complement C2
Determination of some metal ions in various meat and baby food samples by atomic spectrometry.
Kartal et al., Sivas, Turkey. In Food Chem, May 2016
This method is based upon the retention of metal ions on a column packed with poly[N-(3-methyl-1H-indole-1-yl)]-2-methacrylamide-co-2-acrylamido-2-methyl-1-propane sulphonic acid-co divinylbenzene] (MMAD) resin as a solid-phase extraction (SPE) sorbent at pH 8.
Efficient Condensation of DNA into Environmentally Responsive Polyplexes Produced from Block Catiomers Carrying Amine or Diamine Groups.
Giacomelli et al., Santo André, Brazil. In Langmuir, Feb 2016
Taking into account the mentioned issues, herein we have evaluated the DNA condensation ability of poly(ethylene oxide)113-b-poly[2-(diisopropylamino)ethyl methacrylate]50 (PEO113-b-PDPA50), poly(ethylene oxide)113-b-poly[2-(diethylamino)ethyl methacrylate]50 (PEO113-b-PDEA50), poly[oligo(ethylene glycol)methyl ether methacrylate]70-b-poly[oligo(ethylene glycol)methyl ether methacrylate10-co-2-(diethylamino)ethyl methacrylate47-co-2-(diisopropylamino)ethyl methacrylate47] (POEGMA70-b-P(OEGMA10-co-DEA47-co-DPA47), and poly[oligo(ethylene glycol)methyl ether methacrylate]70-b-poly{oligo(ethylene glycol)methyl ether methacrylate10-co-2-methylacrylic acid 2-[(2-(dimethylamino)ethyl)methylamino]ethyl ester44} (POEGMA70-b-P(OEGMA10-co-DAMA44).
Visible-Near-Infrared Range Whispering Gallery Resonance from Photonic μ-Sphere Cavities Self-Assembled from a Blend of Polystyrene and Poly[4,7-bis(3-octylthiophene-2-yl)benzothiadiazole-co-2,6-bis(pyrazolyl)pyridine] Coordinated to Tb(acac)3.
Chandrasekar et al., Hyderābād, India. In Acs Appl Mater Interfaces, Feb 2016
A novel red emitting copolymer (P1) was prepared (Mn ∼ 10.7 kDa) by copolymerizing tridentate ligand, namely 2,6-bis(pyrazolyl)pyridine (BPP) with 4,7-bis(2-ethynyl-5-thienyl)-2,1,3-benzothiadiazole.
Separation of N-derivatized di- and tri-peptide stereoisomers by micro-liquid chromatography using a quinidine-based monolithic column - Analysis of l-carnosine in dietary supplements.
Jiang et al., Guangzhou, China. In J Chromatogr A, Feb 2016
In the present study, a new analytical methodology was developed enabling the enantiomeric determination of N-derivatized di- and tri-peptides in dietary supplements using chiral micro-LC on a monolithic column consisting of poly(O-9-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-co-2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) (poly(MQD-co-HEMA-co-EDMA)).
Synergistic dual-pH responsive copolymer micelles for pH-dependent drug release.
Dong et al., Tianjin, China. In Nanoscale, Feb 2016
This is achieved by the self-assembly of micelles of poly(ethylene glycol)-b-(poly ε-caprolactone-g-poly(2,2-dimethyl-1,3-dioxolane-4-yl)methylacrylate-co-2(dimethylamino)ethyl methacrylate) (mPEG-b-(PCL-g-P(DA-co-DMAEMA))) copolymers with two inert pH responsive moieties of DA and DMAEMA.
Characterization of the bovine milk proteome in early-lactation Holstein and Jersey breeds of dairy cows.
Greenwood et al., Burlington, United States. In J Proteomics, Feb 2016
Bioactive proteins involved in host-defense, including lactotransferrin (P=0.0026) and complement C2 protein (P=0.0001), were differentially expressed by the two breeds, whereas others such as osteopontin (P=0.1788) and lactoperoxidase (P=0.2973) were not.
A knot polymer mediated non-viral gene transfection for skin cells.
Wang et al., Dublin, Ireland. In Biomater Sci, Jan 2016
A knot polymer, poly[bis(2-acryloyl)oxyethyl disulphide-co-2-(dimethylamino) ethyl methacrylate] (DSP), was synthesized, optimized and evaluated as a non-viral vector for gene transfection for skin cells, keratinocytes.
Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy.
Huang et al., Changchun, China. In Biomacromolecules, Jan 2016
Poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2(2-dicarba-closo-dodecarborane)propyloxycarbonyl-propyne carbonate) (PLMB) was synthesized via the versatile reaction between decaborane and side alkynyl groups, and self-assembled with doxorubicin (DOX) to form drug-loaded nanoparticles.
Dendritic Amphiphile Mediated One-Pot Preparation of 3D Pt Nanoparticles-Decorated PolyHIPE as a Durable and Well-Recyclable Catalyst.
Jin et al., Shanghai, China. In Acs Appl Mater Interfaces, Oct 2015
PtNPs are in situ produced and stabilized by a dendritic amphiphile, where the latter consists of a hyperbranched polyethylenimine (PEI) as core and poly(styrene-co-2-ethylhexyl acrylate (P(St-EHA)) as shell.
Thermoresponsive amperometric glucose biosensor.
Schuhmann et al., Bochum, Germany. In Biointerphases, 2014
Screen printed electrodes with heatable gold working electrodes were modified by a thermoresponsive statistical copolymer [polymer I: poly(ω-ethoxytriethylenglycol methacrylate-co-3-(N,N-dimethyl-N-2-methacryloyloxyethyl ammonio) propanesulfonate-co-ω-butoxydiethylenglycol methacrylate-co-2-(4-benzoyl-phenoxy)ethyl methacrylate)] with a lower critical solution temperature of around 28 °C in aqueous solution via electrochemically induced codeposition with a pH-responsive redox-polymer [polymer II: poly(glycidyl methacrylate-co-allyl methacrylate-co-poly(ethylene glycol)methacrylate-co-butyl acrylate-co-2-(dimethylamino)ethyl methacrylate)-[Os(bpy)2(4-(((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)methyl)-N,N-dimethylpicolinamide)](2+)] and pyrroloquinoline quinone-soluble glucose dehydrogenase acting as biological recognition element.
The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis.
Attia et al., Bangkok, Thailand. In Am J Epidemiol, 2012
This meta-analysis provides evidence for an association between C2/CFB polymorphisms and age-related macular degeneration.
Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population.
Chin et al., Inch'ŏn, South Korea. In Exp Eye Res, 2012
In conclusion, the genetic effect of C2, CFB and C3 polymorphisms, which are known to be important for AMD in Caucasian, were not significant in the Korean population.
Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population.
Yoshimura et al., Kyoto, Japan. In Invest Ophthalmol Vis Sci, 2012
C2/CFB variants play a protective role in the risk of developing neovascular AMD and PCV in the Japanese.
Association study of complement factor H, C2, CFB, and C3 and age-related macular degeneration in a Han Chinese population.
Yang et al., China. In Retina, 2010
This study showed that CFH was more likely to be age-related macular(AMD) susceptibility gene, and none of the other C2, CFB, and C3 genes were associated with AMD in a white population.
Impaired opsonization with complement and phagocytosis of Streptococcus pyogenes in sera from subjects with inherited C2 deficiency.
Brown et al., London, United Kingdom. In Microbes Infect, 2010
These data suggest that patients with C2 deficiency are at increased risk of Streptococcus pyogenes infections.
Complement C2 receptor inhibitor trispanning: from man to schistosome.
Inal, Basel, Switzerland. In Springer Semin Immunopathol, 2005
Horizontal gene transfer (HGT), in relation to genetic transfer between hosts and parasites, is a little described mechanism.
The human and mouse MHC class III region: a parade of 21 genes at the centromeric segment.
Miller et al., Columbus, United States. In Immunol Today, 2000
Analysis of the sequence identities of the human and mouse genomic regions between NOTCH4 and complement C2 yields important information on the locations of the coding and regulatory sequences.
Molecular genetics of the human MHC complement gene cluster.
Yu, Columbus, United States. In Exp Clin Immunogenet, 1997
Deficiencies in complement C2 are either due to abolition of C2 protein synthesis by mini-deletions that caused frameshift mutations, or blocked secretion of the C2 protein by single amino acid substitutions.
Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements.
Campbell et al., In Cell, 1987
The human complement protein Factor B is encoded by a single gene in the major histocompatibility complex and is closely linked to the gene encoding the second component of complement C2.
Regulation of class III major histocompatibility complex gene products by interleukin-1.
Colten et al., In Science, 1986
One of two structurally and functionally homologous major histocompatibility complex (MHC) class III genes encodes a positive acute-phase protein, complement factor B. The closely linked complement C2 gene is not affected during the acute-phase response.
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