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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cofilin 1, non-muscle

cofilin, ADF, Destrin
plays a role in nuclear import of actin [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Actin, CAN, V1a, ACID, HAD
Papers using cofilin antibodies
Membrane phosphatidylserine regulates surface charge and protein localization
Grinstein Sergio et al., In The Journal of Cell Biology, 2007
... Signaling Technology, mouse monoclonal anti-Rac1 and anti-Cdc42 were from BD, and rabbit polyclonal anti-cofilin and anti–phospho-cofilin were from Abcam.
Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly
Macara Ian G. et al., In The Journal of Cell Biology, 2000
... Human cofilin-1 was generated by PCR from a human kidney cDNA library (CLONTECH Laboratories, Inc.) and cloned ...
Papers on cofilin
Expression and identification of the ADF-linker-3-1E gene of Eimeria acervulina of chicken.
Jianhua et al., Baoding, China. In Parasitol Res, Feb 2016
This research was conducted to construct the recombinant plasmid pET32a(+)-ADF-linker-3-1E of Eimeria acervulina (E.
RASSF1A suppresses the invasion and metastatic potential of human non-small cell lung cancer cells by inhibiting YAP activation through the GEF-H1/RhoB pathway.
Zalcman et al., Caen, France. In Cancer Res, Feb 2016
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimulating its ability to activate the anti-metastatic small GTPase RhoB.
KIF17 regulates RhoA-dependent actin remodeling at epithelial cell-cell adhesions.
Kreitzer et al., Villejuif, France. In J Cell Sci, Feb 2016
Inhibition of Rho or its effector ROCK, or expression of LIMK1 kinase-dead or activated cofilin(S3A) inhibited KIF17-induced junctional actin accumulation.
Cofilin contributes to phagocytosis of IgG-opsonized particles but not non-opsonized particles in RAW264 macrophages.
Araki et al., Guangzhou, China. In Microscopy (oxf), Feb 2016
UNASSIGNED: Cofilin is an actin-binding protein that severs actin filaments.
Actin-interacting Protein 1 Promotes Disassembly of Actin-depolymerizing Factor/Cofilin-bound Actin Filaments in a pH-dependent Manner.
Ono et al., United States. In J Biol Chem, Feb 2016
UNASSIGNED: Actin-interacting protein 1 (AIP1) is a conserved WD-repeat protein that promotes disassembly of actin filaments when actin-depolymerizing factor (ADF)/cofilin is present.
Roles of LIM kinases in central nervous system function and dysfunction.
Bénédetti et al., Orléans, France. In Febs Lett, Jan 2016
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin.
Cofilin as a Promising Therapeutic Target for Ischemic and Hemorrhagic Stroke.
Shah et al., Toledo, United States. In Transl Stroke Res, Jan 2016
Cofilin is a potent actin-binding protein that severs and depolymerizes actin filaments in order to generate the dynamics of the actin cytoskeleton.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Müller et al., Mainz, Germany. In Neurosci Biobehav Rev, Jan 2016
Identified stress-responsive ABPs include: tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1), ADF/cofilin, LIMK1, caldesmon and myosin VI.
The role of abuse-deterrent formulations in countering opioid misuse and abuse.
Pergolizzi et al., Philadelphia, United States. In J Clin Pharm Ther, Dec 2015
A practical way to retain the pain relief afforded by opioids while decreasing opportunities for abuse is to make it more difficult to extract the opioid from the product or to make it less desirable to do so by designing an abuse-deterrent formulation (ADF).
ADF/cofilin: a crucial regulator of synapse physiology and behavior.
Rust, Marburg an der Lahn, Germany. In Cell Mol Life Sci, Sep 2015
Actin depolymerizing proteins of the ADF/cofilin family are essential regulators of actin dynamics, and a number of recent studies highlighted their crucial functions in excitatory synapses.
Wdr1-mediated cell shape dynamics and cortical tension are essential for epidermal planar cell polarity.
Fuchs et al., New York City, United States. In Nat Cell Biol, May 2015
Here, we identify a key role for Wdr1 (also known as Aip1), an F-actin-binding protein that enhances cofilin/destrin-mediated F-actin disassembly.
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization.
Weinberg et al., Cambridge, United States. In Cancer Cell, 2013
Here, we identify the signaling pathway governing FLP lifetime, which involves integrin-linked kinase (ILK) and β-parvin, two integrin:actin-bridging proteins that block cofilin-mediated actin-filament severing.
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Shatz et al., Stanford, United States. In Science, 2013
The first two extracellular immunoglobulin (Ig) domains of PirB and LilrB2 mediate this interaction, leading to enhanced cofilin signaling, also seen in human AD brains.
Functions of cofilin in cell locomotion and invasion.
Condeelis et al., New York City, United States. In Nat Rev Mol Cell Biol, 2013
Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end.
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression.
Russo et al., New York City, United States. In Nat Med, 2013
Chronic social defeat stress induces the formation of stubby excitatory spines through a Rac1-dependent mechanism involving the redistribution of synaptic cofilin, an actin-severing protein downstream of Rac1.
AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis.
Chen et al., Nanjing, China. In Development, 2012
AIP1 enhances cofilin-mediated actin disassembly in the apical region of precluster cells to promote remodeling of adherense junctions.
Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication.
Wang et al., Guangzhou, China. In J Virol, 2012
These results showed the biphasic F-actin dynamics in herpes simplex virus 1 neuronal infection and confirmed the association of F-actin with the changes in the expression and activity of cofilin 1.
Cofilin-mediated sorting and export of specific cargo from the Golgi apparatus in yeast.
Malhotra et al., Barcelona, Spain. In Mol Biol Cell, 2012
Findings highlight the conserved role of cofilin and SPCA1/Pmr1 in sorting of the soluble secretory proteins at the trans-Golgi network/late Golgi membranes in eukaryotes.
Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Gusev et al., Moscow, Russia. In Arch Biochem Biophys, 2012
cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta
The actin-severing protein cofilin is downstream of neuregulin signaling and is essential for Schwann cell myelination.
Fernandez-Valle et al., Orlando, United States. In J Neurosci, 2012
This study identifies cofilin1 and its upstream regulators, LIMK and SSH1, as end targets of a NRG1 signaling pathway
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