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Cofilin 2

Cofilin 2, CFL2
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: cofilin, Actin, TM3, V1a, CAN
Papers on Cofilin 2
Identification and localization of xylose-binding proteins as potential biomarkers for liver fibrosis/cirrhosis.
Li et al., Xi'an, China. In Mol Biosyst, Jan 2016
PDIA6 and CFL2) responsible for the regulation of protein binding were up-regulated and those responsible for the regulation of catalytic activity (i.e.
Tropomyosin isoforms differentially modulate the regulation of actin filament polymerization and depolymerization by cofilins.
Moraczewska et al., Bydgoszcz, Poland. In Febs J, Jan 2016
Here, we used in vitro assays to examine the regulation of two cofilin isoforms, constitutive cofilin-1 and muscle cofilin-2, by the muscle homodimer Tpm1.1, muscle heterodimer Tpm1.1/Tpm2.2, and the cytoskeletal Tpm3.1s.
Analysis of the differential secretome of nasopharyngeal carcinoma cell lines CNE-2R and CNE-2.
Zhu et al., Nanning, China. In Oncol Rep, Nov 2015
To verify the reliability of iTRAQ quantitative proteomics, we applied western blotting (WB) to study the secretory protein expression of fibrillin-2, CD166, sulfhydryl oxidase 1 and cofilin-2, which are involved in cell adhesion, migration and invasion.
Proteomic changes to the sarcoplasmic fraction of predominantly red or white muscle following acute heat stress.
Lonergan et al., Ames, United States. In J Proteomics, Nov 2015
In the WST, HS decreased abundance of tubulins and soluble actin and increased phosphorylated cofilin 2 abundance, indicating a loss of microtubule structure and a likely increase in stable actin microfilaments.
Tackling proteome changes in the longissimus thoracis bovine muscle in response to pre-slaughter stress.
Zapata et al., Ourense, Spain. In J Proteomics, Jul 2015
A total of seven structural-contractile proteins (three different myosin light chain isoforms, two fast skeletal myosin light chain 2 isoforms, troponin C type 2 and cofilin-2) and three metabolism enzymes (triosephosphate isomerase, ATP synthase and beta-galactoside alpha-2,6-sialyltransferase) were found to have statistically significant differential abundance in sample groups.
Haplotype combination of the bovine CFL2 gene sequence variants and association with growth traits in Qinchuan cattle.
Chen et al., China. In Gene, Jul 2015
The aim of this study was to examine the association of cofilin2 (CFL2) gene polymorphisms with growth traits in Chinese Qinchuan cattle.
Proteomic profile of the skin mucus of farmed gilthead seabream (Sparus aurata).
Prieto-Álamo et al., Córdoba, Spain. In J Proteomics, May 2015
Structural proteins (actins, keratins, tubulins, tropomyosin, cofilin-2 and filamin-A) and metabolic proteins (ribosomal proteins, proteasomal subunits, NACA, VCP, histones, NDPK, transferrin, glycolytic enzymes, ATP synthase components, beta-globin, Apo-A1 and FABP7) were the best represented functional categories.
Cofilin-2 phosphorylation and sequestration in myocardial aggregates: novel pathogenetic mechanisms for idiopathic dilated cardiomyopathy.
Del Monte et al., Roma, Italy. In J Am Coll Cardiol, May 2015
RESULTS: Aggregates in human myocardium were enriched for cofilin-2, an actin-depolymerizing protein known to participate in neurodegenerative diseases and nemaline myopathy.
Dissecting the mechanism of carotid atherosclerosis from the perspective of regulation.
Weng et al., Fuzhou, China. In Int J Mol Med, 2014
MMP9 and CFL2 played key roles in the transcriptional regulatory network.
Skeletal muscle microRNA and messenger RNA profiling in cofilin-2 deficient mice reveals cell cycle dysregulation hindering muscle regeneration.
Agrawal et al., Boston, United States. In Plos One, 2014
Mutations in the gene for cofilin-2 (CFL2) have been identified in several families as a cause of congenital myopathy with nemaline bodies and cores.
microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements.
Götte et al., Münster, Germany. In Plos One, 2014
Supported by transcriptomic Affymetrix array analysis and confirmatory investigations at the mRNA and protein level, we demonstrate that overexpression of miR-142-3p in MDA-MB-231, MDA-MB-468 and MCF-7 breast cancer cells leads to downregulation of WASL (Wiskott-Aldrich syndrome-like, protein: N-WASP), Integrin-αV, RAC1, and CFL2, molecules implicated in cytoskeletal regulation and cell motility.
Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells.
Witowski et al., Vienna, Austria. In Biomed Res Int, 2014
Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome β-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase.
Translational study of Alzheimer's disease (AD) biomarkers from brain tissues in AβPP/PS1 mice and serum of AD patients.
Wang et al., Beijing, China. In J Alzheimers Dis, 2014
Of these 11 proteins, levels of 5 changed in the same direction in the serum of AD patients as they did in mouse brain: cathepsin B, VDAC1, and cofilin-2 increased, and Alix and ACAP1 decreased.
Cofilin-2 controls actin filament length in muscle sarcomeres.
Lappalainen et al., Helsinki, Finland. In Dev Cell, 2014
Here, we demonstrate that the muscle-specific isoform cofilin-2 promotes actin filament disassembly in sarcomeres to control the precise length of thin filaments in the contractile apparatus.
Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance.
Beggs et al., Boston, United States. In Hum Mol Genet, 2012
cofilin-2, although not critical for muscle development, is essential for muscle maintenance.
Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20).
Gusev et al., Moscow, Russia. In Arch Biochem Biophys, 2012
cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 zeta
Remodeling of actin filaments by ADF/cofilin proteins.
Egelman et al., Charlottesville, United States. In Proc Natl Acad Sci U S A, 2012
the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state
Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues.
Nakamura et al., Ube, Japan. In Oncol Rep, 2011
Differential expression of up-regulated cofilin-1 and down-regulated cofilin-2 characteristic of pancreatic cancer tissues
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation.
Katschinski et al., Göttingen, Germany. In J Biol Chem, 2010
PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation
Tropomyosins in skeletal muscle diseases.
Hardeman et al., Sydney, Australia. In Adv Exp Med Biol, 2007
These genes include alpha-skeletal actin (ACTA1), beta-tropomyosin (TPM2), alpha-tropomyosin slow (TPM3), nebulin (NEB), troponin I fast (TNNI2), troponin T slow (TNNT1), troponin T fast (TNNT3) and cofilin (CFL2).
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