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Ciliary neurotrophic factor receptor

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: Ciliary Neurotrophic Factor, NMDA receptor, Interleukin-6, LIF, CAN
Papers on CNTFRalpha
Neurotrophin signaling in a genitofemoral nerve target organ during testicular descent in mice.
Hutson et al., Melbourne, Australia. In J Pediatr Surg, Jan 2016
Sagittal sections of IFP, mammary area and bulbocavernosus (BC) muscle were processed for standard histology and fluorescent immunohistochemistry for ciliary neurotrophic factor (CNTF), ciliary neurotrophic factor receptor (CNTFR) and cell nuclei (DAPI).
Ciliary neurotrophic factor (CNTF): New facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies.
Gauchat et al., Montréal, Canada. In Cytokine Growth Factor Rev, Oct 2015
Since the side effects of CNTF might be linked to its ability to activate the alternative IL6Rα-LIFRβ-gp130 receptor, CNTFR-specific mutants of CNTF have been developed that bind to the CNTFRα-LIFRβ-gp130 receptor.
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders.
Sims, Australia. In Cytokine Growth Factor Rev, Oct 2015
These cytokines are members of the IL-6 superfamily, and form a range of composite cytokines that signal through gp130 bound either to the ciliary neurotrophic factor receptor (CNTFR) or a complex that involves the IL-27 p28 subunit.
The Acquisition of Target Dependence by Developing Rat Retinal Ganglion Cells(1,2,3).
Harvey et al., Perth, Australia. In Eneuro, May 2015
Prior to innervation RGCs expressed high levels of BDNF and CNTFR α but lower levels of neurexin 1 mRNA.
Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity.
IMAGE Consortium et al., Greensboro, United States. In Am J Med Genet B Neuropsychiatr Genet, 2014
SNPs within neurotrophic (NTRK3) and cytokine genes (CNTFR) were associated with ADHD inattentive symptom severity.
Prospection of genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line.
Mota et al., Jaboticabal, Brazil. In Animal, 2014
Genes involved in muscle growth (n=8), skeletal growth (n=10), muscle energy metabolism (n=15), cardiovascular system (n=14) and nervous system (n=23) were identified, including the FKTN, INSR, GYS1, CLCN1, MYLK, SYK, ANG, CNTFR and HTR2B.
High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.
Amaral et al., Lisbon, Portugal. In Cell, 2013
Subsequent detailed investigation revealed ciliary neurotrophic factor receptor (CNTFR) as an ENaC modulator and showed that inhibition of (diacylglycerol kinase, iota) DGKι, a protein involved in PiP2 metabolism, downgrades ENaC activity, leading to normalization of both Na+ and fluid absorption in CF airways to non-CF levels in primary human lung cells from CF patients.
The anorectic effect of CNTF does not require action in leptin-responsive neurons.
Seeley et al., Cincinnati, United States. In Endocrinology, 2012
Data show that CNTF receptor alpha subunit, CNTFRalpha, signaling in leptin-responsive neurons is not required for endogenous maintenance of energy balance.
Expression of neurotrophin receptors by retinoinvasive uveal melanoma.
Finger et al., New York City, United States. In Melanoma Res, 2012
expression of neurotrophin receptors Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-alpha in ulveal melanoma does not show a role in growth.
The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.
Vacher et al., Orsay, France. In Am J Physiol Endocrinol Metab, 2012
The data strongly suggested that intracellular ciliary neurotrophic factor may directly modulate proopiomelanocortin gene expression via the activation of ciliary neurotrophic factor receptors in the cell nucleus.
Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus.
Watt et al., Grand Forks, United States. In Exp Neurol, 2012
The results of this study showed taht increased CNTF and CNTFR complex in the sprouting, metabolically active supraoptic nucleus are related directly to the sprouting response and not the increase in neurosecretory activity.
Cytokine-like factor 1 (CLF1): life after development?
Kass, Pittsburgh, United States. In Cytokine, 2011
CLF1 and its physiologic partner, cardiotrophin-like cytokine (CLC) are secreted as a heterodimer and engage the tripartite signaling complex of ciliary neurotrophic factor receptor (CNTFR), leukemia inhibitory factor (LIFR) and gp130.
Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.
Estivill et al., Barcelona, Spain. In J Psychiatr Res, 2010
Data show that variants in CNTFR were significantly associated with a lower age at onset of the eating disorders.
Humanin and the receptors for humanin.
Hashimoto et al., Tokyo, Japan. In Mol Neurobiol, 2010
Most recently, it has been shown that Humanin inhibits neuronal cell death and dysfunction by binding to a novel IL-6-receptor-related receptor(s) on the cell surface involving CNTFRalpha, WSX-1, and gp130.
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Steinberg et al., Melbourne, Australia. In Nat Med, 2006
Here, we show that CNTF signals through the CNTFRalpha-IL-6R-gp130beta receptor complex to increase fatty-acid oxidation and reduce insulin resistance in skeletal muscle by activating AMP-activated protein kinase (AMPK), independent of signaling through the brain.
Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3)/cardiotrophin-like cytokine (CLC)--a novel gp130 cytokine with pleiotropic functions.
Auernhammer et al., München, Germany. In Cytokine Growth Factor Rev, 2004
NNT-1/BSF-3 is a second ligand to the tripartite CNTFR complex and activates Jak-STAT, MAPK and PI3/Akt signaling pathways in various cell systems.
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.
Yancopoulos et al., New York City, United States. In Cell, 1995
We have generated and directly compared mice containing null mutations in the genes encoding CNTF or its receptor (CNTFR alpha).
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle.
DiStefano et al., New York City, United States. In Cell, 1994
The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor components, CNTFR alpha, is expressed by skeletal muscle.
LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
Yancopoulos et al., United States. In Science, 1993
The ciliary neurotrophic factor (CNTF) receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFR beta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)].
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