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Natriuretic peptide C

CNP, C-type natriuretic peptide, CNPase
The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: Phosphodiesterase, NPR-B, CAN, ANP, BNP
Papers using CNP antibodies
Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy
Ogawa Hisao et al., In International Journal of Vascular Medicine, 2006
... The serum level of CNP was measured using the CNP-22 EIA Kit (Phoenix Pharmaceuticals, Karlsruhe, Germany) according to ...
Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons
Gallo Vittorio et al., In The Journal of Cell Biology, 2001
... CNP-GFP transgenic mouse model ...
Papers on CNP
White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy.
Lee et al., Baltimore, United States. In Neuroscience, Jan 2016
White matter neurons were also counted, and apoptotic cells were immunophenotyped with the oligodendrocyte marker 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase).
Higher level of NT-proCNP in cerebrospinal fluid of patients with meningitis.
Mikaszewska-Sokolewicz et al., Warsaw, Poland. In Neurosci Lett, Jan 2016
UNASSIGNED: Aminoterminal pro-C type Natriuretic Peptide (NT-proCNP) as an active form of CNP, has been recently proven to be a potential marker of sepsis and to be linked to inflammatory diseases.
C-Type Natriuretic Peptide Analog as Therapy for Achondroplasia.
Legeai-Mallet, Paris, France. In Endocr Dev, Dec 2015
Several preclinical studies have been conducted such as the C-type natriuretic peptide (CNP) analog (BMN111), intermittent parathyroid hormone injections, soluble FGFR3 therapy, and meclozine and statin treatments.
The Effects of Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation During the Acute and Subacute Phases Following Spinal Cord Injury.
Karaoz et al., İstanbul, Turkey. In Turk Neurosurg, Dec 2015
The regeneration process was evaluated based on immunostaining against β3-tubulin, BDNF, CNTF, and CNPase.
Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway.
Qin et al., Hefei, China. In J Recept Signal Transduct Res, Nov 2015
C-type natriuretic peptide (CNP) is considered as a positive regulator of bone formation.
Advances in treatment of achondroplasia and osteoarthritis.
Horton et al., Portland, United States. In Hum Mol Genet, Nov 2015
The strongest candidate therapy employs an analog of C-type natriuretic peptide (CNP), which antagonizes the mitogen-activated-protein (MAP) kinase pathway downstream of the FGFR3 receptor and may also act independently in the growth plate.
Structural and functional evolution of 2',3'-cyclic nucleotide 3'-phosphodiesterase.
Kursula et al., Oulu, Finland. In Brain Res, Oct 2015
UNASSIGNED: 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) is an abundant membrane-associated enzyme within the vertebrate myelin sheath.
Microengineered embryonic stem cells niche to induce neural differentiation.
Tavana et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
The expression of specific neural cell markers glial fibrillary acidic protein (GFAP), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), and tyrosine hydroxylase (TH) is elevated during the second week of culture.
Achondroplasia: Current Options and Future Perspective.
Latrech et al., In Pediatr Endocrinol Rev, Jun 2015
In this article, we discuss a number of treatments from the surgical limb lengthening approach and the Recombinant Growth Hormone (rhGH) treatment, to future treatments, which include the Natriuretic Peptide C-type (CNP).
The influence of glutamatergic receptor antagonists on biochemical and ultrastructural changes in myelin membranes of rats subjected to experimental autoimmune encephalomyelitis.
Sulkowski et al., Warsaw, Poland. In Folia Neuropathol, 2014
The aim of the study was to test the effects of the glutamatergic receptor antagonists amantadine and memantine (antagonists of NMDA receptors), LY 367384 (an antagonist of mGluR1), and MPEP (an mGluR5 antagonist) on the development of neurological symptoms in immunized animals, morphological changes in cerebral myelin, and expression of mRNA of the principal myelin proteins PLP, MBP, MOG, MAG, and CNPase.
The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.
Mohapatra et al., Iowa City, United States. In J Neurosci, 2012
GTP-binding protein betagamma subunit-dependent potentiation of TRPV1 as novel signaling cascades recruited by CNP in dorsal root ganglia neurons leads to enhanced nociceptor excitability and thermal hypersensitivity and increases neuronal firing frequency.
Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.
Fowkes et al., London, United Kingdom. In Endocr Relat Cancer, 2012
NPR2 expression in normal human fetal and adult pituitaries and adenomatous pituitary tissue and suggest a role for these receptors in both pituitary development and oncogenesis.
Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival.
Kuo et al., Madison, United States. In Clin Cancer Res, 2012
Differential CNP expression correlated with mouse model survival, and CNP immunoassay of a large GBM tissue microarray also showed significant differential patient survival
C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
Eckstein et al., München, Germany. In Eur J Vasc Endovasc Surg, 2012
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery.
A myelin gene causative of a catatonia-depression syndrome upon aging.
Ehrenreich et al., Göttingen, Germany. In Embo Mol Med, 2012
The characteristic features in both humans and mice with their partial CNP 'loss-of-function' genotype are best described as 'catatonia-depression' syndrome.
In vivo targeted delivery of nanoparticles for theranosis.
Kwon et al., Seoul, South Korea. In Acc Chem Res, 2011
Through these experiments, we developed a glycol chitosan nanoparticle (CNP), which is suitable for angiogenic diseases, such as cancers, even without an additional targeting moiety.
Axon-glial signaling and the glial support of axon function.
Trapp et al., Göttingen, Germany. In Annu Rev Neurosci, 2007
The underlying mechanisms are still poorly understood; we do know that to maintain axonal integrity, mammalian myelin-forming cells require the expression of some glia-specific proteins, including CNP, PLP, and MAG, as well as intact peroxisomes, none of which is necessary for myelin assembly.
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.
Dickey et al., Minneapolis, United States. In Endocr Rev, 2006
The mammalian members are atrial natriuretic peptide, B-type natriuretic peptide, C-type natriuretic peptide, and possibly osteocrin/musclin.
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.
Fern et al., Leicester, United Kingdom. In Nature, 2006
During modelled ischaemia, NMDA receptor activation resulted in rapid Ca2+-dependent detachment and disintegration of oligodendroglial processes in the white matter of mice expressing green fluorescent protein (GFP) specifically in oligodendrocytes (CNP-GFP mice).
Large-scale copy number polymorphism in the human genome.
Wigler et al., United States. In Science, 2004
On average, individuals differed by 11 CNPs, and the average length of a CNP interval was 465 kilobases.
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