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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein phosphatase 3, catalytic subunit, alpha isozyme

CNA, calcineurin Aalpha
Member of the class III HD-ZIP protein family. Contains homeodomain and leucine zipper domain. Critical for vascular development and negatively regulates vascular cell differentiation. (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, CNB, V1a
Papers using CNA antibodies
Amphivasal vascular bundle 1, a gain-of-function mutation of the IFL1/REV gene, is associated with alterations in the polarity of leaves, stems and carpels
He Yuke et al., In Journal of Experimental Botany, 2003
... CNA::2mCNA oe-160c, ARF16::5mARF16, arf10-3 arf16-2, jaw-1D, and TCP3SRDX mutants and transgenic lines have been previously ...
Papers on CNA
Genotoxic potential of montmorillonite clay mineral and alteration in the expression of genes involved in toxicity mechanisms in the human hepatoma cell line HepG2.
Zegura et al., Sevilla, Spain. In J Hazard Mater, Apr 2016
Montmorillonite, also known as Cloisite(®)Na(+) (CNa(+)), is a natural clay with a wide range of well-documented and novel applications, such as pharmaceutical products or food packaging.
Relationship of immunohistochemistry, copy number aberrations and epigenetic disorders with BRCAness pattern in hereditary and sporadic breast cancer.
Bolufer Gilabert et al., Valencia, Spain. In Fam Cancer, Feb 2016
UNASSIGNED: The study aims to identify the relevance of immunohistochemistry (IHC), copy number aberrations (CNA) and epigenetic disorders in BRCAness breast cancers (BCs).
PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer.
Maehara et al., Fukuoka, Japan. In J Thorac Oncol, Jan 2016
METHODS: We investigated copy number alterations (CNAs) in the PD-L1 gene by real-time PCR in 94 surgically resected lung cancer samples to find possible associations between PD-L1 CNA and lung cancer biology.
Targeting Signaling Transduction Pathways in Bladder Cancer.
Plimack et al., Philadelphia, United States. In Curr Oncol Rep, Dec 2015
Simultaneously, a rationale for such therapies has come to the forefront of management of this disease because an overabundance of signaling pathways are genetically deranged as a result of point mutation or copy number alteration (CNA) as identified by several recent next generation sequencing (NGS) studies.
Loss at 16q22.1 identified as a risk factor for intrahepatic recurrence in hepatocellular carcinoma and screening of differentially expressed genes.
Cong et al., In Neoplasma, Dec 2015
Copy number alteration (CNA) of chromosome 16, a frequent genetic event in tumors including hepatocellular carcinoma (HCC), has been associated with HCC etiology of hepatitis B virus (HBV) and with clinical outcomes in multiple types of cancer.
The extent of whole-genome copy number alterations predicts aggressive features in primary melanomas.
Ciarrocchi et al., Reggio nell'Emilia, Italy. In Pigment Cell Melanoma Res, Dec 2015
Using a SNP-array approach, we quantified chromosomal copy number alterations (CNA) across the whole-genome in 41 primary melanomas and found a high degree of heterogeneity in their genomic asset.
Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy(1,2,3).
Valentino et al., Philadelphia, United States. In Eneuro, Nov 2015
Sections through the nucleus paragigantocellularis (PGi) and central amygdalar nucleus (CNA), major sources of enkephalin (ENK) and CRF LC afferents, respectively, were immunocytochemically processed to detect c-fos, FG, and CRF or ENK.
[Role of calcineurin-nuclear factor of activated T cells signaling pathway in myoblast apoptosis induced by cyclic tensile strain].
Yuan et al., In Hua Xi Kou Qiang Yi Xue Za Zhi, Oct 2015
The mRNA expression of the CaN subunits, CnA and CnB, and the protein levels of NFAT3 also increased.
Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack.
Ylstra et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2014
Therefore, it is possible that a single gene in a focal CNA gives the tumor a selective growth advantage.
Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma.
Chen et al., Taipei, Taiwan. In World J Gastroenterol, 2014
Because a large amount of HCC genomic data genotyped by high density single nucleotide polymorphism arrays is deposited in the public domain, copy number alteration (CNA) analyses of these arrays is a cost-effective way to reveal target genes through profiling of recurrent and overlapping amplicons, homozygous deletions and potentially unbalanced chromosomal translocations accumulated during HCC progression.
Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma.
Shen et al., Ningbo, China. In Int J Clin Exp Pathol, 2013
The tumor cells expressed conventional FDC markers such as CD21 (75%), CD35 (92%), CD23 (62%), clusterin (75%), and CNA.42 (100%).
Calcineurin: a poorly understood regulator of muscle mass.
Price et al., Atlanta, United States. In Int J Biochem Cell Biol, 2013
This review will discuss the existing literature that has examined the role of calcineurin (CnA) in the regulation of skeletal muscle mass in conditions associated with hypertrophic growth or atrophy.
Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer.
Solit et al., New York City, United States. In J Clin Oncol, 2013
Unsupervised clustering of CNAs defined two distinct classes of bladder tumors that differed in the degree of their CNA burden.
The shaping and functional consequences of the microRNA landscape in breast cancer.
Caldas et al., Cambridge, United Kingdom. In Nature, 2013
Notably, only prognostic miRNA signatures derived from breast tumours devoid of somatic copy-number aberrations (CNA-devoid) are consistently prognostic across several other subtypes and can be validated in external cohorts.
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.
Wakabayashi et al., Suita, Japan. In Mol Cell Biol, 2012
NHE1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
Crystallization and preliminary crystallographic study of a trypsin-resistant catalytic domain of human calcineurin.
Shi et al., Beijing, China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
calcineurin crystal of trypsin-resistant catalytic domain belonged to the orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 161.6, b = 87.4, c = 112.0 A
Increased ratio of calcineurin immunoreactive neurons in the caudate nucleus of patients with schizophrenia.
Niwa et al., Fukushima, Japan. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
Alterations in calcineurin signaling in the caudate nucleus contribute to the pathogenesis of schizophrenia.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Investigation of two Wnt signalling pathway single nucleotide polymorphisms in a breast cancer-affected Australian population.
Griffiths et al., Griffith, Australia. In Twin Res Hum Genet, 2011
Even though an association of the polymorphisms rs2850328 and rs2395 and breast cancer was not detected in our case-control study population, other variants within the PPP3CA and MARK4 genes may still be associated with breast cancer.
The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation.
McKeon et al., Boston, United States. In Cell, 1994
We have created calcineurins that are resistant to both cyclosporin A and FK506 by mutating specific residues in CnB, a calcium-binding protein that regulates the catalytic subunit, CnA.
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