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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


Clusterin, apolipoprotein J, SGP-2, apoJ, CLU
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: CD45, CAN, apolipoprotein E, AGE, ACID
Papers using Clusterin antibodies
Anionic phospholipids lose their procoagulant properties when incorporated into high density lipoproteins
Reitsma Pieter H., In PLoS ONE, 2008
... human apolipoprotein A-I was from Calbiochem (Darmstadt, Germany) and the goat polyclonal IgG to human apolipoprotein J was from Abgent (San Diego, CA, USA) ...
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... ClusterinMenarini1:30negativeEMADAKO ...
Papers on Clusterin
Integrative proteomics and transcriptomics identify novel invasive-related biomarkers of non-functioning pituitary adenomas.
Zhang et al., Beijing, China. In Tumour Biol, Feb 2016
Eight genes were identified involved in the invasion function by the molecular and cellular functions analysis, including CAT, CLU, CHGA, EZR, KRT8, LIMA1, SH3GLB2 and SLC2A1.
Complement Activation In Leprosy: A Retrospective Study Shows Elevated Circulating Terminal Complement Complex In Reactional Leprosy.
Baas et al., Amsterdam, Netherlands. In Clin Exp Immunol, Feb 2016
In addition, levels of the regulator Clusterin (p ≤0.001 without R; p<0.05 with R) were also elevated in MB patients irrespective of a reaction.
Proteomics of vitreous in neovascular age-related macular degeneration.
Koss et al., Heidelberg, Germany. In Exp Eye Res, Feb 2016
Using a stringent statistical analysis with implementation of the closed test principle, we were able to identify four proteins that may be involved in the pathophysiology of nAMD: Clusterin, opticin, pigment epithelium-derived factor and prostaglandin-H2 d-isomerase.
Label-free quantitative proteomic analysis of benzo(a)pyrene-transformed 16HBE cells serum-free culture supernatant and xenografted nude mice sera.
Zhou et al., Beijing, China. In Chem Biol Interact, Jan 2016
Three proteins neuropilin-2 (NRP2), clusterin (CLU) and A-kinase anchor protein 12 (AKAP12) were up-regulated in the serum-free culture supernatant of T-16HBE-C1 cells.
The CLU-files: disentanglement of a mystery.
Koch-Brandt et al., In Biomol Concepts, Jan 2016
Today, secretory clusterin (sCLU), also known as apolipoprotein J (apoJ), is considered one of the most important extracellular chaperones ever found.
Protein structures in Alzheimer's disease: The basis for rationale therapeutic design.
Villegas et al., Barcelona, Spain. In Arch Biochem Biophys, Jan 2016
Thus, structural information available for APP, α- β- and γ-secretases, CTFβ and derived Aβ peptides, AICDs, apoE and apoJ, LRP-1 and RAGE, and neprilysin and insulin-degrading enzyme is provided.
[Down-regulated clusterin expression enhances sensitivity of hepatoma cells to anti-cancer drugs].
Yao et al., Nantong, China. In Zhonghua Gan Zang Bing Za Zhi, Dec 2015
OBJECTIVE: To investigate the relationship between and underlying mechanistic pathway of clusterin (CLU) and chemo-resistance ofhepatocellular carcinoma (HCC) cells.
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.
Pocock et al., London, United Kingdom. In Curr Opin Neurobiol, Nov 2015
The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 and SORL1) [2-8], and many encode proteins which are highly expressed in microglia [1].
Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis.
Wiggs et al., Boston, United States. In Exp Eye Res, Oct 2015
Clusterin (CLU) is an extracellular matrix chaperone that prevents protein aggregation and is highly expressed in ocular tissues affected by XFS.
Apolipoprotein J: A New Predictor and Therapeutic Target in Cardiovascular Disease?
Qin et al., Tianjin, China. In Chin Med J (engl), Oct 2015
The terms of "atherosclerosis, apolipoprotein J, clusterin (CLU), oxidative stress, and inflammation" were used for searching.
Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.
Maple-Grødem et al., Stavanger, Norway. In Parkinsons Dis, 2014
The aim of this study was to investigate whether candidate polymorphisms in five genes (ADAM10, BACE1, BACE2, PSEN2, and CLU) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study.
Seminal clusterin gene expression associated with seminal variables in fertile and infertile men.
Mostafa et al., Al Manşūrah, Egypt. In J Urol, 2012
Clusterin gene expression was significantly increased in the semen samples of infertile men.
Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study.
Kuller et al., Pittsburgh, United States. In Am J Psychiatry, 2012
CLU and CR1 were associated with more rapid cognitive decline. PICALM was associated with an earlier age at midpoint of cognitive decline.
Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages.
Min et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these findings describe a novel function for clusterin as an inducer of TNF-alpha in macrophages and their chemotactic migration, and suggest that clusterin has a tumor-promoting effect.
Stable knockdown of clusterin by vectorbased RNA interference in a human breast cancer cell line inhibits tumour cell invasion and metastasis.
Chen et al., Anqing, China. In J Int Med Res, 2011
CLU may regulate the aggressive behaviour of human breast cancer cells through modulation of ERK signalling and MMP9 expression.
Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.
Sachdev et al., Sydney, Australia. In Plos One, 2011
Higher plasma ApoJ levels predicted white matter atrophy over two years in a cohort of older individuals with Mild Cognitive Impairment.
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Amouyel et al., Lille, France. In Nat Genet, 2009
Two loci gave replicated evidence of association with Alzheimer's disease: one within CLU on chromosome 8 and the other within CR1 on chromosome 1.
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Williams et al., Cardiff, United Kingdom. In Nat Genet, 2009
Having removed Single Nucleotide Polymorphism within the APOE, CLU and PICALM loci from the analysis, focused on those that showed the most evidence for association with Alzheimer's disease
Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial.
Nelson et al., Los Angeles, United States. In Jama, 2006
No treatment-related change was observed in prostate histology, tissue biomarkers (androgen receptor, Ki-67, CD34), gene expression (including AR, PSA, PAP2A, VEGF, NXK3, CLU [Clusterin]), or cancer incidence or severity.
Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.
Holtzman et al., Saint Louis, United States. In Nat Med, 2001
Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death.
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