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ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog

ClpP, Endopeptidase Clp
The protein encoded by this gene belongs to the peptidase family S14 and hydrolyzes proteins into small peptides in the presence of ATP and magnesium. The protein is transported into mitochondrial matrix and is associated with the inner mitochondrial membrane. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Clp, ClpX, CAN, ATPase, TBX22
Papers on ClpP
Photocurrent enhancement of SiNW-FETs by integrating protein-shelled CdSe quantum dots.
Kim et al., Suwŏn, South Korea. In Nanoscale, Feb 2016
CdSe QDs were synthesized using ClpP, a bacterial protease, as protein shells to control the size and stability of QD and to facilitate the mounting of QDs on SiNWs.
The keepers of the ring: regulators of FtsZ assembly.
Vicente et al., Madrid, Spain. In Fems Microbiol Rev, Jan 2016
Finally, ClpP degrades FtsZ, an action prevented by ZipA.
Two complete chloroplast genomes of white campion (Silene latifolia) from male and female individuals.
Tembrock et al., Fort Collins, United States. In Mitochondrial Dna, Jan 2016
In these protein-coding genes, eight genes (rpl16, rpoC1, rps16, petD, petB, ndhB, ndhA and atpF) contain a single intron and three genes (rps12, clpP and ycf3) contain two introns.
The complete chloroplast genome of Sinopodophyllum hexandrum Ying (Berberidaceae).
Ding et al., Kunming, China. In Mitochondrial Dna, Jan 2016
In these genes, eight harbored a single intron, and two (ycf3 and clpP) contained a couple of introns.
Phylogenomic and structural analyses of 18 complete plastomes across all families of early-diverging eudicots, including an angiosperm-wide analysis of IR gene content evolution.
Wang et al., Wuhan, China. In Mol Phylogenet Evol, Jan 2016
All of the newly sequenced plastomes share the same 79 protein-coding genes, 4 rRNA genes, and 30 tRNA genes, except for that of Epimedium, in which infA is pseudogenized and clpP is highly divergent and possibly a pseudogene.
Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.
Van Remmen et al., Oklahoma City, United States. In Free Radic Biol Med, Jan 2016
UNASSIGNED: The caseinolytic peptidase P (ClpP) is the endopeptidase component of the mitochondrial matrix ATP-dependent ClpXP protease.
Targeting Mycobacterial Enzymes with Natural Products.
Sieniawska, Lublin, Poland. In Chem Biol, Nov 2015
Here, natural metabolites are presented as being inhibitors/activators of the mycobacterial enzymes involved in mycobacterial growth in vitro (ClpC1, ClpP, MurE ligase, mycothiol S-conjugate amidase, β-ketoacyl-ACP synthase, InhA) and in vivo, as regards the host cell (PtpB).
Conditional repression of essential chloroplast genes: Evidence for new plastid signaling pathways.
Ramundo et al., Genève, Switzerland. In Biochim Biophys Acta, Sep 2015
This approach has been used to analyze three chloroplast genes of this sort coding for the α subunit of RNA polymerase (rpoA), a ribosomal protein (rps12) and the catalytic subunit of the ATP-dependent ClpP protease (clpP1).
Organization, function and substrates of the essential Clp protease system in plastids.
van Wijk et al., Ithaca, United States. In Biochim Biophys Acta, Sep 2015
The Clp system consists of a tetradecameric proteolytic core with catalytically active ClpP and inactive ClpR subunits, hexameric ATP-dependent chaperones (ClpC,D) and adaptor protein(s) (ClpS1) enhancing delivery of subsets of substrates.
Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.
Schimmer et al., Toronto, Canada. In Cancer Cell, Jul 2015
From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells.
Antagonizing ClpP: A New Power Play in Targeted Therapy for AML.
Byrd et al., Columbus, United States. In Cancer Cell, Jul 2015
In this issue of Cancer Cell, Cole and colleagues report a non-mutant mitochondrial protein (ClpP) that is overexpressed in a wide range of acute myeloid leukemia (AML) cases, but not in normal hematopoietic precursors.
Loss of chloroplast ClpP elicits an autophagy-like response in Chlamydomonas.
Rochaix et al., Genève, Switzerland. In Autophagy, 2014
Chloroplast genomes contain a single ClpP1 gene encoding one of the catalytic subunits of the evolutionarily conserved ATP-dependent Clp protease.
Activated ClpP kills persisters and eradicates a chronic biofilm infection.
Lewis et al., Boston, United States. In Nature, 2013
The acyldepsipeptide antibiotic (ADEP4) has been shown to activate the ClpP protease, resulting in death of growing cells.
Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine.
Sauer et al., Cambridge, United States. In Cell, 2013
ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and translocate target proteins into the ClpP peptidase for degradation.
Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis.
van Wijk et al., Ithaca, United States. In Plant Cell, 2011
Data determine the exact subunit composition and stoichiometry for the intact core and each ring of the chloroplast ClpP/R protease.
ClpX(P) generates mechanical force to unfold and translocate its protein substrates.
Bustamante et al., Berkeley, United States. In Cell, 2011
We report direct observations of mechanical, force-induced protein unfolding by the ClpX unfoldase from E. coli, alone, and in complex with the ClpP peptidase.
Multistep processing of an insertion sequence in an essential subunit of the chloroplast ClpP complex.
Vallon et al., Paris, France. In J Biol Chem, 2009
ClpP1 results from endoproteolytic cleavage inside an in-frame insertion sequence in Chlamydomonas reinhardii.
Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.
Bouton et al., Gif-sur-Yvette, France. In Febs J, 2009
The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA.
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
Bross et al., Århus, Denmark. In Neuroscience, 2008
We propose that decreased levels of mitochondrial proteases Lon and ClpP may allow heat shock protein 60 substrate proteins to go through more folding attempts
A nuclear-encoded ClpP subunit of the chloroplast ATP-dependent Clp protease is essential for early development in Arabidopsis thaliana.
Clarke et al., Umeå, Sweden. In Planta, 2006
Lines with > 90% loss of wild type levels of ClpP4 protein were severely bleached and strongly retarded in vegetative growth, failing to reach reproductive maturity.
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