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Collectin sub-family member 12

Clp1, Flp1, scavenger receptor with C-type lectin, hClp1
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Clp, ACID, CAN, V1a, PCNA
Papers on Clp1
A mutation in the Cc.arp9 gene encoding a putative actin-related protein causes defects in fruiting initiation and asexual development in the agaricomycete Coprinopsis cinerea.
Nakahori et al., Kyoto, Japan. In Curr Genet, Feb 2016
The effects of mutations in Cc.arp9 and Cc.snf5 on oidia production and the transcriptional expression levels of clp1 and pcc1, which are under the control of the A gene, were also examined.
Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway.
Garred et al., Copenhagen, Denmark. In J Immunol, Nov 2015
Recently, a new member of the collectin family named collectin-12 (CL-12 or CL-P1) has been identified.
Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype.
Madan et al., Mumbai, India. In Int Immunol, Apr 2015
Transcripts of PRRs such as all Toll-like receptors (TLR1-10), except TLR8, collectins (CL-L1, CL-P1 and CL-K1), NOD-1 and NOD-2 receptors and secreted pro-inflammatory cytokines like IL-6, IFN-γ, vascular endothelial growth factor (VEGF), epidermal growth factor and MCP-1 were significantly up-regulated in ectopic MSCs.
The putative cellodextrin transporter-like protein CLP1 is involved in cellulase induction in Neurospora crassa.
Ma et al., Tianjin, China. In J Biol Chem, Feb 2015
Here, we discovered a novel membrane protein, cellodextrin transporter-like protein 1 (CLP1; NCU05853), a putative cellodextrin transporter-like protein that is a critical component of the cellulase induction pathway in N. crassa.
CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.
Martinez et al., Vienna, Austria. In Wiley Interdiscip Rev Rna, 2015
Our study on a mouse carrying a catalytically inactive version of the RNA kinase CLP1, a component of the tRNA splicing endonuclease complex, revealed a neurological disorder characterized by progressive loss of lower spinal motor neurons.
Scavenger receptor CL-P1 mainly utilizes a collagen-like domain to uptake microbes and modified LDL.
Wakamiya et al., Asahikawa, Japan. In Biochim Biophys Acta, 2014
Collectin placenta 1 (CL-P1) showed scavenger receptor activity as functions in vitro, and has three candidate domains: a coiled-coil domain, a collagen-like domain and CRD.
Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2.
Wakamiya et al., Asahikawa, Japan. In Biochim Biophys Acta, 2014
BACKGROUND: Scavenger receptor CL-P1 (collectin placenta 1) has been found recently as a first membrane-type collectin which is mainly expressed in vascular endothelial cells.
CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.
Gleeson et al., San Diego, United States. In Cell, 2014
From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1).
Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function.
Lupski et al., Houston, United States. In Cell, 2014
CLP1 is a RNA kinase involved in tRNA splicing.
A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe.
McInerny et al., Glasgow, United Kingdom. In Plos One, 2013
Furthermore, we observed defective endosomal sorting in mutants of plo1, ark1 and clp1, as has been reported for ESCRT mutants, consistent with a role for these kinases in the control of ESCRT function in membrane traffic.
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Penninger et al., Vienna, Austria. In Nature, 2013
CLP1 was the first mammalian RNA kinase to be identified.
Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1.
Wakamiya et al., Asahikawa, Japan. In J Biomed Biotechnol, 2011
These "novel collectins" consist of collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1) and are encoded by three separate genes.
Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin.
Taylor et al., London, United Kingdom. In J Biol Chem, 2011
The common presence of Lewis(x) groups in granule protein glycans can thus target granule proteins for clearance by SRCL.
Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast.
McInerny, In Cell Cycle, 2011
Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast.
DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools.
Wagener et al., Hamburg, Germany. In Eur J Cell Biol, 2010
The Le(x) residues of both, CEACAM1 and CEA, interact with the human Le(x)-binding glycan receptors DC-SIGN and SRCL.
A link between aurora kinase and Clp1/Cdc14 regulation uncovered by the identification of a fission yeast borealin-like protein.
Gould et al., Nashville, United States. In Mol Biol Cell, 2009
Results identify Nbl1, a borealin-like protein that provides a link between aurora kinase and Clp1/Cdc14, and cytokinesis, in Schizosaccharomyces pombe [Nbl1].
Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells.
Wakamiya et al., Asahikawa, Japan. In J Biol Chem, 2009
CL-P1 predominantly mediated phagocytosis for fungi in vascular endothelia.
The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.
Martinez et al., Vienna, Austria. In Nature, 2007
the kinase hClp1 phosphorylates and licenses synthetic siRNAs to become assembled into RISC for subsequent target RNA cleavage
Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential.
Gounari et al., Boston, United States. In Nat Immunol, 2003
Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor alpha, we identified a common lymphocyte precursor (CLP-2) population that, in contrast to the previously identified CLP-1 population, was c-Kit-B220+.
Signal transduction and transcriptional adaptation in embryonic heart development and during myocardial hypertrophy.
Siddiqui et al., New York City, United States. In Mol Cell Biochem, 1999
A cell specific transcription factor, CLP-1, was recently identified in our laboratory that is likely to play a crucial role, in conjunction with other known regulatory factors, in early cardiac events leading to cardiogenic cell specification and differentiation.
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